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- W2065197962 abstract "RATIONALE: ADAM33 has been identified as a novel asthma susceptibility gene in genome-wide screening and association studies. We evaluated whether ADAM33 expression is higher in the airways of asthmatics than normal controls (NC) and its clinical relevance. METHODS: The ADAM33 protein was identified in the BAL fluids of asthmatics and normal controls using Western blotting with antibody against the catalytic domain. ADAM33 expression was analyzed using immunohistochemical staining of mucosal biopsy specimens. The levels of ADAM33 protein in the BAL fluids were measured by dot blotting. RESULTS: Western blot analysis revealed the presence of the ADAM33 protein with a molecular mass of 70-80 kDa in the BAL fluids. ADAM33 was expressed in the smooth muscles and basement membranes of almost all the asthmatics, but was absent in the normal controls. The ADAM33 levels were increased significantly in asthmatics, as compared to normal control subjects (p= 0.001). The ADAM33 protein levels correlated inversely with the FEV1% pred in the asthmatics (r = -0.421, p = 0.02). CONCLUSIONS: ADAM33 is associated with asthma development, and the levels of ADAM protein are related to asthma severity. This study was supported by a grant of the Korean Health 21 R&D project, Ministry of Health & Welfare, Republic of Korea (01-PJ10-PG6-01GN14-0003)." @default.
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- W2065197962 date "2005-02-01" @default.
- W2065197962 modified "2023-09-24" @default.
- W2065197962 title "A disintegrin and metalloproteinase(ADAM33) protein in asthmatics: Relevance to airflow limitation" @default.
- W2065197962 doi "https://doi.org/10.1016/j.jaci.2004.12.571" @default.
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