FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065201865> ?p ?o ?g. }

• W2065201865 endingPage "67" @default.
• W2065201865 startingPage "58" @default.
• W2065201865 abstract "Mycoplasma hyopneumoniae is the causative agent of swine enzootic pneumonia (EP), a disease that causes considerable economic losss in swine industry. Lipid-associated membrane proteins (LAMPs) of mycoplasma play important roles in causing mycoplasma diseases. The present study explores the pathogenic mechanisms of M. hyopneumoniae LAMPs by elucidating their role in modulating the inflammation, apoptosis, and relevant signaling pathways of peripheral blood mononuclear cells (PBMCs) of pig. LAMP treatment inhibited the growth of PBMCs. Up-regulation of cytokines, such as IL-6 and IL-1β, as well as increased production of nitric oxide (NO) and superoxide anion were all detected in the supernatant of LAMPs-treated PBMCs. Furthermore, flow cytometric analysis using dual staining with annexin-V-FITC and propidium iodide (PI) showed that LAMPs of M. hyopneumoniae induced a time-dependent apoptosis in lymphocyts and monocytes from PBMCs, which was blocked by NOS inhibitor or antioxidant. In addition, LAMPs induced the phosphorylation of p38, the ratio of pro-apoptotic Bax protein to anti-apoptotic Bcl-2, activation of caspase-3 and caspase-8, and poly ADP-ribose polymerase (PARP) cleavage in PBMCs. These findings demonstrated that M. hyopneumoniae LAMPs induced the production of proinflammatory cytokines, NO and reactive oxygen species (ROS), and apoptosis of PBMCs in vitro through p38 MAPK and Bax/Bcl-2 signaling pathways, as well as caspase activation." @default.
• W2065201865 created "2016-06-24" @default.
• W2065201865 creator A5001660753 @default.
• W2065201865 creator A5011031724 @default.
• W2065201865 creator A5013768764 @default.
• W2065201865 creator A5048718607 @default.
• W2065201865 creator A5065784466 @default.
• W2065201865 creator A5077017582 @default.
• W2065201865 date "2015-01-01" @default.
• W2065201865 modified "2023-10-16" @default.
• W2065201865 title "Mycoplasma hyopneumoniae-derived lipid-associated membrane proteins induce inflammation and apoptosis in porcine peripheral blood mononuclear cells in vitro" @default.
• W2065201865 cites W1820527381 @default.
• W2065201865 cites W1966971174 @default.
• W2065201865 cites W1974221331 @default.
• W2065201865 cites W1976385326 @default.
• W2065201865 cites W1977258127 @default.
• W2065201865 cites W1986600448 @default.
• W2065201865 cites W1988043250 @default.
• W2065201865 cites W1988636621 @default.
• W2065201865 cites W1995555691 @default.
• W2065201865 cites W1998809668 @default.
• W2065201865 cites W2001492710 @default.
• W2065201865 cites W2009158642 @default.
• W2065201865 cites W2009630603 @default.
• W2065201865 cites W2012992792 @default.
• W2065201865 cites W2020357295 @default.
• W2065201865 cites W2037233339 @default.
• W2065201865 cites W2046795682 @default.
• W2065201865 cites W2048810119 @default.
• W2065201865 cites W2054144570 @default.
• W2065201865 cites W2058497310 @default.
• W2065201865 cites W2063988301 @default.
• W2065201865 cites W2071416628 @default.
• W2065201865 cites W2075124803 @default.
• W2065201865 cites W2077323870 @default.
• W2065201865 cites W2077624270 @default.
• W2065201865 cites W2087877138 @default.
• W2065201865 cites W2088609052 @default.
• W2065201865 cites W2089185720 @default.
• W2065201865 cites W2092751085 @default.
• W2065201865 cites W2096718691 @default.
• W2065201865 cites W2108791332 @default.
• W2065201865 cites W2134505828 @default.
• W2065201865 cites W2142749240 @default.
• W2065201865 cites W2147005219 @default.
• W2065201865 cites W2148125367 @default.
• W2065201865 cites W2154024433 @default.
• W2065201865 cites W2158627911 @default.
• W2065201865 cites W2161901859 @default.
• W2065201865 cites W4236851451 @default.
• W2065201865 doi "https://doi.org/10.1016/j.vetmic.2014.11.013" @default.
• W2065201865 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25481242" @default.
• W2065201865 hasPublicationYear "2015" @default.
• W2065201865 type Work @default.
• W2065201865 sameAs 2065201865 @default.
• W2065201865 citedByCount "35" @default.
• W2065201865 countsByYear W20652018652016 @default.
• W2065201865 countsByYear W20652018652017 @default.
• W2065201865 countsByYear W20652018652018 @default.
• W2065201865 countsByYear W20652018652019 @default.
• W2065201865 countsByYear W20652018652020 @default.
• W2065201865 countsByYear W20652018652021 @default.
• W2065201865 countsByYear W20652018652022 @default.
• W2065201865 countsByYear W20652018652023 @default.
• W2065201865 crossrefType "journal-article" @default.
• W2065201865 hasAuthorship W2065201865A5001660753 @default.
• W2065201865 hasAuthorship W2065201865A5011031724 @default.
• W2065201865 hasAuthorship W2065201865A5013768764 @default.
• W2065201865 hasAuthorship W2065201865A5048718607 @default.
• W2065201865 hasAuthorship W2065201865A5065784466 @default.
• W2065201865 hasAuthorship W2065201865A5077017582 @default.
• W2065201865 hasConcept C137061746 @default.
• W2065201865 hasConcept C153911025 @default.
• W2065201865 hasConcept C164027704 @default.
• W2065201865 hasConcept C190283241 @default.
• W2065201865 hasConcept C202751555 @default.
• W2065201865 hasConcept C203014093 @default.
• W2065201865 hasConcept C2775934118 @default.
• W2065201865 hasConcept C2776914184 @default.
• W2065201865 hasConcept C2780383596 @default.
• W2065201865 hasConcept C31573885 @default.
• W2065201865 hasConcept C55493867 @default.
• W2065201865 hasConcept C86803240 @default.
• W2065201865 hasConcept C89423630 @default.
• W2065201865 hasConceptScore W2065201865C137061746 @default.
• W2065201865 hasConceptScore W2065201865C153911025 @default.
• W2065201865 hasConceptScore W2065201865C164027704 @default.
• W2065201865 hasConceptScore W2065201865C190283241 @default.
• W2065201865 hasConceptScore W2065201865C202751555 @default.
• W2065201865 hasConceptScore W2065201865C203014093 @default.
• W2065201865 hasConceptScore W2065201865C2775934118 @default.
• W2065201865 hasConceptScore W2065201865C2776914184 @default.
• W2065201865 hasConceptScore W2065201865C2780383596 @default.
• W2065201865 hasConceptScore W2065201865C31573885 @default.
• W2065201865 hasConceptScore W2065201865C55493867 @default.
• W2065201865 hasConceptScore W2065201865C86803240 @default.
• W2065201865 hasConceptScore W2065201865C89423630 @default.
• W2065201865 hasFunder F4320321001 @default.

• next