Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065202391> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2065202391 endingPage "319" @default.
- W2065202391 startingPage "319" @default.
- W2065202391 abstract "Objective Evaluate the time-course, severity and resolution patterns of adverse events (AEs) occurring with long-term aripiprazole treatment for irritability associated with autistic disorder. Methods Participants were treated with aripiprazole in a 52-week, open-label, flexibly dosed (2–15 mg/day) study. Subjects had either completed one of two 8-week randomised trials or were de novo. AEs with an incidence of ≥10% were evaluated by incidence, peak first onset, severity, percent resolved and time to resolution. Results A total of 330 subjects entered open-label treatment; 199 completed 52 weeks. Mean dose for the population stabilised at around 10 mg/day after approximately 4 months. Thirteen AEs had an incidence of ≥10%; most were mild or moderate in severity. Vomiting, diarrhoea and headache had an early first onset and tended to resolve fairly quickly. Sedation, fatigue and insomnia also appeared early and resolved in a majority of cases, but not as quickly. Increased appetite appeared early (followed by increased weight) and fewer weight-related AEs resolved. More than half of the subjects increased their weight by at least one percentile category rank; nevertheless, only a small proportion of subjects with normal baseline metabolic or glucose measures had a treatment-emergent, clinically relevant laboratory abnormality. Nasopharyngitis, upper respiratory infection, cough, nasal congestion and pyrexia all had peak onset at variable times during the study, resolving in nearly all cases, with short time to resolution. Conclusion AEs were mostly mild or moderate and of variable duration. Increased weight was observed." @default.
- W2065202391 created "2016-06-24" @default.
- W2065202391 creator A5000677832 @default.
- W2065202391 creator A5003276388 @default.
- W2065202391 creator A5008049518 @default.
- W2065202391 creator A5024194700 @default.
- W2065202391 creator A5027638832 @default.
- W2065202391 creator A5029547645 @default.
- W2065202391 creator A5055769971 @default.
- W2065202391 creator A5057330556 @default.
- W2065202391 date "2011-03-01" @default.
- W2065202391 modified "2023-09-27" @default.
- W2065202391 title "Safety and tolerability of aripiprazole in the treatment of irritability associated with autistic disorder in pediatric patients: Results from a 52-week open-label study" @default.
- W2065202391 doi "https://doi.org/10.1016/s0924-9338(11)72028-4" @default.
- W2065202391 hasPublicationYear "2011" @default.
- W2065202391 type Work @default.
- W2065202391 sameAs 2065202391 @default.
- W2065202391 citedByCount "0" @default.
- W2065202391 crossrefType "journal-article" @default.
- W2065202391 hasAuthorship W2065202391A5000677832 @default.
- W2065202391 hasAuthorship W2065202391A5003276388 @default.
- W2065202391 hasAuthorship W2065202391A5008049518 @default.
- W2065202391 hasAuthorship W2065202391A5024194700 @default.
- W2065202391 hasAuthorship W2065202391A5027638832 @default.
- W2065202391 hasAuthorship W2065202391A5029547645 @default.
- W2065202391 hasAuthorship W2065202391A5055769971 @default.
- W2065202391 hasAuthorship W2065202391A5057330556 @default.
- W2065202391 hasConcept C118552586 @default.
- W2065202391 hasConcept C120665830 @default.
- W2065202391 hasConcept C121332964 @default.
- W2065202391 hasConcept C126322002 @default.
- W2065202391 hasConcept C141071460 @default.
- W2065202391 hasConcept C187212893 @default.
- W2065202391 hasConcept C197934379 @default.
- W2065202391 hasConcept C2776412080 @default.
- W2065202391 hasConcept C2777844070 @default.
- W2065202391 hasConcept C2778311950 @default.
- W2065202391 hasConcept C2778375690 @default.
- W2065202391 hasConcept C2778562196 @default.
- W2065202391 hasConcept C2780211496 @default.
- W2065202391 hasConcept C2780820931 @default.
- W2065202391 hasConcept C2908647359 @default.
- W2065202391 hasConcept C511355011 @default.
- W2065202391 hasConcept C544821477 @default.
- W2065202391 hasConcept C61511704 @default.
- W2065202391 hasConcept C71924100 @default.
- W2065202391 hasConcept C99454951 @default.
- W2065202391 hasConceptScore W2065202391C118552586 @default.
- W2065202391 hasConceptScore W2065202391C120665830 @default.
- W2065202391 hasConceptScore W2065202391C121332964 @default.
- W2065202391 hasConceptScore W2065202391C126322002 @default.
- W2065202391 hasConceptScore W2065202391C141071460 @default.
- W2065202391 hasConceptScore W2065202391C187212893 @default.
- W2065202391 hasConceptScore W2065202391C197934379 @default.
- W2065202391 hasConceptScore W2065202391C2776412080 @default.
- W2065202391 hasConceptScore W2065202391C2777844070 @default.
- W2065202391 hasConceptScore W2065202391C2778311950 @default.
- W2065202391 hasConceptScore W2065202391C2778375690 @default.
- W2065202391 hasConceptScore W2065202391C2778562196 @default.
- W2065202391 hasConceptScore W2065202391C2780211496 @default.
- W2065202391 hasConceptScore W2065202391C2780820931 @default.
- W2065202391 hasConceptScore W2065202391C2908647359 @default.
- W2065202391 hasConceptScore W2065202391C511355011 @default.
- W2065202391 hasConceptScore W2065202391C544821477 @default.
- W2065202391 hasConceptScore W2065202391C61511704 @default.
- W2065202391 hasConceptScore W2065202391C71924100 @default.
- W2065202391 hasConceptScore W2065202391C99454951 @default.
- W2065202391 hasIssue "S2" @default.
- W2065202391 hasLocation W20652023911 @default.
- W2065202391 hasOpenAccess W2065202391 @default.
- W2065202391 hasPrimaryLocation W20652023911 @default.
- W2065202391 hasRelatedWork W1999044453 @default.
- W2065202391 hasRelatedWork W1999630630 @default.
- W2065202391 hasRelatedWork W2061864344 @default.
- W2065202391 hasRelatedWork W2083931142 @default.
- W2065202391 hasRelatedWork W2153329282 @default.
- W2065202391 hasRelatedWork W2409957712 @default.
- W2065202391 hasRelatedWork W4210849476 @default.
- W2065202391 hasRelatedWork W4313304374 @default.
- W2065202391 hasRelatedWork W4365511387 @default.
- W2065202391 hasRelatedWork W2471868719 @default.
- W2065202391 hasVolume "26" @default.
- W2065202391 isParatext "false" @default.
- W2065202391 isRetracted "false" @default.
- W2065202391 magId "2065202391" @default.
- W2065202391 workType "article" @default.