FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065222310> ?p ?o ?g. }

• W2065222310 endingPage "805" @default.
• W2065222310 startingPage "794" @default.
• W2065222310 abstract "One major pathological hallmark of Alzheimer's disease (AD) is accumulation of senile plaques in patients' brains, mainly composed of amyloid beta-peptide (Aβ). Nicotinamide adenine dinucleotide (NAD) has emerged as a common mediator regulating energy metabolism, mitochondrial function, aging, and cell death, all of which are critically involved in neuronal demise observed in AD. In this work, we tested the hypothesis that NAD may attenuate Aβ-induced DNA damages, thereby conferring neuronal resistance to primary rat cortical cultures. We found that co-incubation of NAD dose-dependently attenuated neurotoxicity mediated by Aβ25-35 and Aβ1-42 in cultured rat cortical neurons, with the optimal protective dosage at 50 mM. NAD also abolished the formation of reactive oxygen species (ROS) induced by Aβ25-35. Furthermore, Aβs were capable of inducing oxidative DNA damages by increasing the extents of 8-hydroxy-2´-deoxyguanosine (8-OH-dG), numbers of apurinic/apyrimidinic (AP) sites, genomic DNA single-stranded breaks (SSBs), as well as DNA double-stranded breaks (DSBs)/fragmentation, which can all be attenuated upon co-incubation with NAD. Our results thus reveal a novel finding that NAD is protective against DNA damage induced by existing Aβ, leading ultimately to neuroprotection in primary cortical culture." @default.
• W2065222310 created "2016-06-24" @default.
• W2065222310 creator A5017867567 @default.
• W2065222310 creator A5039677388 @default.
• W2065222310 creator A5046257966 @default.
• W2065222310 creator A5064265355 @default.
• W2065222310 creator A5075654268 @default.
• W2065222310 date "2014-04-22" @default.
• W2065222310 modified "2023-09-26" @default.
• W2065222310 title "NAD attenuates oxidative DNA damages induced by amyloid beta-peptide in primary rat cortical neurons" @default.
• W2065222310 cites W1970554352 @default.
• W2065222310 cites W1981075890 @default.
• W2065222310 cites W1995557989 @default.
• W2065222310 cites W2001665323 @default.
• W2065222310 cites W2005608816 @default.
• W2065222310 cites W2005719973 @default.
• W2065222310 cites W2008654020 @default.
• W2065222310 cites W2009224937 @default.
• W2065222310 cites W2024755124 @default.
• W2065222310 cites W2032463467 @default.
• W2065222310 cites W2036732999 @default.
• W2065222310 cites W2041985732 @default.
• W2065222310 cites W2044555983 @default.
• W2065222310 cites W2046323909 @default.
• W2065222310 cites W2050734026 @default.
• W2065222310 cites W2052411385 @default.
• W2065222310 cites W2055883416 @default.
• W2065222310 cites W2056585943 @default.
• W2065222310 cites W2056648984 @default.
• W2065222310 cites W2057552703 @default.
• W2065222310 cites W2076531205 @default.
• W2065222310 cites W2078944454 @default.
• W2065222310 cites W2097839503 @default.
• W2065222310 cites W2111191371 @default.
• W2065222310 cites W2129085204 @default.
• W2065222310 cites W2152732481 @default.
• W2065222310 cites W2158748165 @default.
• W2065222310 cites W2161678021 @default.
• W2065222310 cites W2166956025 @default.
• W2065222310 cites W2168693839 @default.
• W2065222310 cites W2313691240 @default.
• W2065222310 doi "https://doi.org/10.3109/10715762.2014.907889" @default.
• W2065222310 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24678962" @default.
• W2065222310 hasPublicationYear "2014" @default.
• W2065222310 type Work @default.
• W2065222310 sameAs 2065222310 @default.
• W2065222310 citedByCount "37" @default.
• W2065222310 countsByYear W20652223102014 @default.
• W2065222310 countsByYear W20652223102015 @default.
• W2065222310 countsByYear W20652223102016 @default.
• W2065222310 countsByYear W20652223102017 @default.
• W2065222310 countsByYear W20652223102018 @default.
• W2065222310 countsByYear W20652223102019 @default.
• W2065222310 countsByYear W20652223102020 @default.
• W2065222310 countsByYear W20652223102021 @default.
• W2065222310 countsByYear W20652223102022 @default.
• W2065222310 countsByYear W20652223102023 @default.
• W2065222310 crossrefType "journal-article" @default.
• W2065222310 hasAuthorship W2065222310A5017867567 @default.
• W2065222310 hasAuthorship W2065222310A5039677388 @default.
• W2065222310 hasAuthorship W2065222310A5046257966 @default.
• W2065222310 hasAuthorship W2065222310A5064265355 @default.
• W2065222310 hasAuthorship W2065222310A5075654268 @default.
• W2065222310 hasConcept C142724271 @default.
• W2065222310 hasConcept C143425029 @default.
• W2065222310 hasConcept C153911025 @default.
• W2065222310 hasConcept C178790620 @default.
• W2065222310 hasConcept C181199279 @default.
• W2065222310 hasConcept C185592680 @default.
• W2065222310 hasConcept C190283241 @default.
• W2065222310 hasConcept C25498285 @default.
• W2065222310 hasConcept C2776156579 @default.
• W2065222310 hasConcept C2776901170 @default.
• W2065222310 hasConcept C2776925932 @default.
• W2065222310 hasConcept C2777633098 @default.
• W2065222310 hasConcept C2779134260 @default.
• W2065222310 hasConcept C2779281246 @default.
• W2065222310 hasConcept C2779491297 @default.
• W2065222310 hasConcept C28859421 @default.
• W2065222310 hasConcept C29730261 @default.
• W2065222310 hasConcept C31573885 @default.
• W2065222310 hasConcept C43759708 @default.
• W2065222310 hasConcept C48349386 @default.
• W2065222310 hasConcept C552990157 @default.
• W2065222310 hasConcept C55493867 @default.
• W2065222310 hasConcept C59822182 @default.
• W2065222310 hasConcept C71924100 @default.
• W2065222310 hasConcept C75520062 @default.
• W2065222310 hasConcept C86803240 @default.
• W2065222310 hasConcept C95444343 @default.
• W2065222310 hasConcept C98274493 @default.
• W2065222310 hasConceptScore W2065222310C142724271 @default.
• W2065222310 hasConceptScore W2065222310C143425029 @default.
• W2065222310 hasConceptScore W2065222310C153911025 @default.
• W2065222310 hasConceptScore W2065222310C178790620 @default.
• W2065222310 hasConceptScore W2065222310C181199279 @default.
• W2065222310 hasConceptScore W2065222310C185592680 @default.
• W2065222310 hasConceptScore W2065222310C190283241 @default.

• next