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- W2065229590 abstract "A fast method was developed to determine the amount of anions and cations present in discovery samples using a reagent free ion chromatography system. The system separates and quantifies counterions present in novel discovery compounds from an accurately weighed sample of 1 mg. The advantage of using these methods in the discovery phase and early development to accurately characterize salt identity and stoichiometry has been demonstrated. Likewise, a further advantage is the ability to accurately quantify undesirable counterions that may be present due to process related manipulation of material and to quantify salt equivalents for “mixed” salt samples. The instrumentation described also has the ability to utilize a reagent-free automated eluent generation approach which in addition to saving time, eliminates the variability that can occur with manually prepared eluents. Several examples have been collated to highlight the usefulness of this approach within discovery." @default.
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- W2065229590 date "2012-04-13" @default.
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- W2065229590 title "COUNTERION QUANTIFICATION FOR DISCOVERY CHEMISTRY AND PRE-FORMULATION SALT SCREENING" @default.
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