Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065238460> ?p ?o ?g. }
- W2065238460 endingPage "214" @default.
- W2065238460 startingPage "194" @default.
- W2065238460 abstract "Despite remarkable effort, malignant melanoma still remains a potent killer. Millions of dollars have been spent on clinical trials that have not succeeded in achieving significant patient benefit. The thorough validation of drug targets at an earlier stage is, therefore, an essential step in the development of new therapies. Since the development of microarray experiments, putative drug targets are being identified in a high-throughput manner. Though high-throughput functional validation methods are currently being established, a more specific, pre-clinical analysis of promising target genes remains inevitable. For this, a broad range of increasingly sophisticated functional models is available. In vitro, the microenvironment of skin can be simulated through various two or three-dimensional models. In vivo assays range from xenograft studies to the establishment of transgenic organisms. Here, we provide a summary of functional interrogation approaches in melanoma research, focusing on the application of these strategies to the development of new effective therapies." @default.
- W2065238460 created "2016-06-24" @default.
- W2065238460 creator A5010597176 @default.
- W2065238460 creator A5063303093 @default.
- W2065238460 creator A5074034520 @default.
- W2065238460 creator A5088690848 @default.
- W2065238460 date "2009-12-01" @default.
- W2065238460 modified "2023-10-16" @default.
- W2065238460 title "Identification and functional validation of therapeutic targets for malignant melanoma" @default.
- W2065238460 cites W141162965 @default.
- W2065238460 cites W1499765524 @default.
- W2065238460 cites W1509715834 @default.
- W2065238460 cites W1528955439 @default.
- W2065238460 cites W1554172105 @default.
- W2065238460 cites W1597791301 @default.
- W2065238460 cites W1607745684 @default.
- W2065238460 cites W1642344961 @default.
- W2065238460 cites W1648301895 @default.
- W2065238460 cites W1651215666 @default.
- W2065238460 cites W1828940258 @default.
- W2065238460 cites W1910423580 @default.
- W2065238460 cites W1949238489 @default.
- W2065238460 cites W1965122083 @default.
- W2065238460 cites W1965977173 @default.
- W2065238460 cites W1965989317 @default.
- W2065238460 cites W1967251768 @default.
- W2065238460 cites W1967342065 @default.
- W2065238460 cites W1967835627 @default.
- W2065238460 cites W1968403457 @default.
- W2065238460 cites W1970241639 @default.
- W2065238460 cites W1971571835 @default.
- W2065238460 cites W1972325604 @default.
- W2065238460 cites W1976060898 @default.
- W2065238460 cites W1976468436 @default.
- W2065238460 cites W1977491728 @default.
- W2065238460 cites W1979994960 @default.
- W2065238460 cites W1981075588 @default.
- W2065238460 cites W1982442966 @default.
- W2065238460 cites W1982580546 @default.
- W2065238460 cites W1982889687 @default.
- W2065238460 cites W1983685718 @default.
- W2065238460 cites W1986301169 @default.
- W2065238460 cites W1989076816 @default.
- W2065238460 cites W1989121777 @default.
- W2065238460 cites W1990253589 @default.
- W2065238460 cites W1990507217 @default.
- W2065238460 cites W1991658600 @default.
- W2065238460 cites W1992443647 @default.
- W2065238460 cites W1992762728 @default.
- W2065238460 cites W1993336164 @default.
- W2065238460 cites W1994672904 @default.
- W2065238460 cites W1994869675 @default.
- W2065238460 cites W1995654591 @default.
- W2065238460 cites W1996760332 @default.
- W2065238460 cites W1997091783 @default.
- W2065238460 cites W1997585129 @default.
- W2065238460 cites W1997919830 @default.
- W2065238460 cites W1999746960 @default.
- W2065238460 cites W2000315568 @default.
- W2065238460 cites W2000492480 @default.
- W2065238460 cites W2000742881 @default.
- W2065238460 cites W2001351884 @default.
- W2065238460 cites W2003633088 @default.
- W2065238460 cites W2004422079 @default.
- W2065238460 cites W2006985176 @default.
- W2065238460 cites W2007501617 @default.
- W2065238460 cites W2014304644 @default.
- W2065238460 cites W2014550839 @default.
- W2065238460 cites W2015009944 @default.
- W2065238460 cites W2015085911 @default.
- W2065238460 cites W2015729243 @default.
- W2065238460 cites W2015893533 @default.
- W2065238460 cites W2016636248 @default.
- W2065238460 cites W2017806952 @default.
- W2065238460 cites W2019496774 @default.
- W2065238460 cites W2019751519 @default.
- W2065238460 cites W2020727013 @default.
- W2065238460 cites W2021129827 @default.
- W2065238460 cites W2025147250 @default.
- W2065238460 cites W2025316386 @default.
- W2065238460 cites W2030092260 @default.
- W2065238460 cites W2033386446 @default.
- W2065238460 cites W2033919910 @default.
- W2065238460 cites W2034713890 @default.
- W2065238460 cites W2035542471 @default.
- W2065238460 cites W2036697376 @default.
- W2065238460 cites W2037141750 @default.
- W2065238460 cites W2038153134 @default.
- W2065238460 cites W2041882103 @default.
- W2065238460 cites W2042004955 @default.
- W2065238460 cites W2042760441 @default.
- W2065238460 cites W2045159513 @default.
- W2065238460 cites W2047909390 @default.
- W2065238460 cites W2049299149 @default.
- W2065238460 cites W2050193465 @default.
- W2065238460 cites W2050910055 @default.
- W2065238460 cites W2051000382 @default.
- W2065238460 cites W2051221156 @default.