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• W2065258027 abstract "The nuclear receptor steroidogenic factor 1 (SF-1) is expressed in a precise time and cell-specific pattern in the endocrine system. Three intronic enhancers and one upstream enhancer, which are required for controlling the restricted expression of SF-1, have been identified in the mouse gene encoding SF-1. In recent years, efforts from several laboratories have established that expression of SF-1 is controlled by DNA methylation. CpG-sites are found in the basal promoter as well as in the intronic enhancers, and the methylation status of these genomic regions nearly perfectly correlates with their transcriptional activity such that they are hypomethylated in tissues where they are active, and generally hypermethylated in tissues where they are not active. This review summarizes the present knowledge of how tissue differentially methylated regions control the transcriptional activity of the SF-1 gene, and how irregularities in the methylation pattern can contribute to disease development." @default.
• W2065258027 created "2016-06-24" @default.
• W2065258027 creator A5004655946 @default.
• W2065258027 creator A5046533177 @default.
• W2065258027 creator A5068160649 @default.
• W2065258027 date "2013-05-01" @default.
• W2065258027 modified "2023-09-26" @default.
• W2065258027 title "Epigenetic regulation of the gene encoding steroidogenic factor-1" @default.
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• W2065258027 doi "https://doi.org/10.1016/j.mce.2012.12.028" @default.
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