FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065258301> ?p ?o ?g. }

• W2065258301 endingPage "118" @default.
• W2065258301 startingPage "108" @default.
• W2065258301 abstract "Resveratrol(RSV) is an edible polyphenolic phytoalexin present in different plant species that plays an important role in improving endothelial dysfunction. However, the molecular mechanisms underlying these effects are unknown. In the present study, the mechanism underlying the protection of CRL-1730 cells by RSV against oxidative stress was examined.We first assessed the effects of RSV on the cell viability and apoptosis of CRL-1730 cells exposed to hydrogen peroxide(H2O2). Real-time PCR was used to determine the microRNA-126(miR-126) expression in cells treated with RSV and/or H2O2. We also evaluated the PI3K/Akt signaling pathway in CRL-1730 cells following upregulation of the miR-126 expression. Finally, we determined the effects of miR-126 on RSV against oxidative injury using an miR-126 inhibitor.Treatment with RSV resulted in a significant increase in survival and a decrease in the apoptosis of CRL-1730 cells exposed to H2O2. We also found that H2O2 significantly suppressed the expression of miR-126, which was reversed by RSV in a dose-dependent manner. The overexpression of miR-126 decreased PIK3R2(p85-β) and enhanced Akt phosphorylation, which resulted in an increase in the survival of CRL-1730 cells exposed to H2O2. More importantly, the downregulation of the miR-126 expression reversed the effects of RSV on the survival and apoptosis of CRL-1730 cells exposed to H2O2. In addition, the knockdown of Ets-1 reversed the effects of RSV on the miR-126 expression in CRL-1730 cells exposed to H2O2.In this study, we demonstrated that the protection of endothelial cells by RSV against oxidative injury is due to the activation of PI3K/Akt by miR-126." @default.
• W2065258301 created "2016-06-24" @default.
• W2065258301 creator A5007786523 @default.
• W2065258301 creator A5009727303 @default.
• W2065258301 creator A5019733531 @default.
• W2065258301 creator A5068576354 @default.
• W2065258301 date "2014-01-01" @default.
• W2065258301 modified "2023-10-06" @default.
• W2065258301 title "Resveratrol Inhibits Hydrogen Peroxide-Induced Apoptosis in Endothelial Cells via the Activation of PI3K/Akt by miR-126" @default.
• W2065258301 cites W144423133 @default.
• W2065258301 cites W1576985941 @default.
• W2065258301 cites W1973262582 @default.
• W2065258301 cites W1977871132 @default.
• W2065258301 cites W1980149585 @default.
• W2065258301 cites W1996004246 @default.
• W2065258301 cites W2018944696 @default.
• W2065258301 cites W2021862872 @default.
• W2065258301 cites W2024105041 @default.
• W2065258301 cites W2028456697 @default.
• W2065258301 cites W2034289205 @default.
• W2065258301 cites W2039179232 @default.
• W2065258301 cites W2067038367 @default.
• W2065258301 cites W2068223162 @default.
• W2065258301 cites W2069546816 @default.
• W2065258301 cites W2073807083 @default.
• W2065258301 cites W2092873565 @default.
• W2065258301 cites W2104568691 @default.
• W2065258301 cites W2128597483 @default.
• W2065258301 cites W2129994868 @default.
• W2065258301 cites W2163294226 @default.
• W2065258301 cites W2166598872 @default.
• W2065258301 cites W50981894 @default.
• W2065258301 doi "https://doi.org/10.5551/jat.19257" @default.
• W2065258301 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24107596" @default.
• W2065258301 hasPublicationYear "2014" @default.
• W2065258301 type Work @default.
• W2065258301 sameAs 2065258301 @default.
• W2065258301 citedByCount "38" @default.
• W2065258301 countsByYear W20652583012014 @default.
• W2065258301 countsByYear W20652583012015 @default.
• W2065258301 countsByYear W20652583012016 @default.
• W2065258301 countsByYear W20652583012017 @default.
• W2065258301 countsByYear W20652583012018 @default.
• W2065258301 countsByYear W20652583012019 @default.
• W2065258301 countsByYear W20652583012020 @default.
• W2065258301 countsByYear W20652583012021 @default.
• W2065258301 countsByYear W20652583012022 @default.
• W2065258301 countsByYear W20652583012023 @default.
• W2065258301 crossrefType "journal-article" @default.
• W2065258301 hasAuthorship W2065258301A5007786523 @default.
• W2065258301 hasAuthorship W2065258301A5009727303 @default.
• W2065258301 hasAuthorship W2065258301A5019733531 @default.
• W2065258301 hasAuthorship W2065258301A5068576354 @default.
• W2065258301 hasBestOaLocation W20652583011 @default.
• W2065258301 hasConcept C104317684 @default.
• W2065258301 hasConcept C127561419 @default.
• W2065258301 hasConcept C173396325 @default.
• W2065258301 hasConcept C185592680 @default.
• W2065258301 hasConcept C190283241 @default.
• W2065258301 hasConcept C2776151105 @default.
• W2065258301 hasConcept C2776816829 @default.
• W2065258301 hasConcept C502942594 @default.
• W2065258301 hasConcept C53227056 @default.
• W2065258301 hasConcept C533411734 @default.
• W2065258301 hasConcept C55493867 @default.
• W2065258301 hasConcept C75217442 @default.
• W2065258301 hasConcept C86554907 @default.
• W2065258301 hasConcept C86803240 @default.
• W2065258301 hasConcept C95444343 @default.
• W2065258301 hasConcept C98274493 @default.
• W2065258301 hasConceptScore W2065258301C104317684 @default.
• W2065258301 hasConceptScore W2065258301C127561419 @default.
• W2065258301 hasConceptScore W2065258301C173396325 @default.
• W2065258301 hasConceptScore W2065258301C185592680 @default.
• W2065258301 hasConceptScore W2065258301C190283241 @default.
• W2065258301 hasConceptScore W2065258301C2776151105 @default.
• W2065258301 hasConceptScore W2065258301C2776816829 @default.
• W2065258301 hasConceptScore W2065258301C502942594 @default.
• W2065258301 hasConceptScore W2065258301C53227056 @default.
• W2065258301 hasConceptScore W2065258301C533411734 @default.
• W2065258301 hasConceptScore W2065258301C55493867 @default.
• W2065258301 hasConceptScore W2065258301C75217442 @default.
• W2065258301 hasConceptScore W2065258301C86554907 @default.
• W2065258301 hasConceptScore W2065258301C86803240 @default.
• W2065258301 hasConceptScore W2065258301C95444343 @default.
• W2065258301 hasConceptScore W2065258301C98274493 @default.
• W2065258301 hasIssue "2" @default.
• W2065258301 hasLocation W20652583011 @default.
• W2065258301 hasLocation W20652583012 @default.
• W2065258301 hasOpenAccess W2065258301 @default.
• W2065258301 hasPrimaryLocation W20652583011 @default.
• W2065258301 hasRelatedWork W1550129979 @default.
• W2065258301 hasRelatedWork W1990034595 @default.
• W2065258301 hasRelatedWork W2411921067 @default.
• W2065258301 hasRelatedWork W2934456842 @default.
• W2065258301 hasRelatedWork W2949555002 @default.
• W2065258301 hasRelatedWork W2996100833 @default.
• W2065258301 hasRelatedWork W3155677549 @default.

• next