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- W2065260129 abstract "The maintenance of tolerance is the <i>sine qua non</i> of a sophisticated regulatory apparatus to prevent or dampen overzealous immune responses. In addition to the ability of B cells to prime and activate the immune system, B cells with regulatory function (Bregs) have been identified in experimental models of autoimmunity, infections, and cancer, supporting the notion that, similar to regulatory T cells (Tregs), Breg-mediated suppression is an important means for the maintenance of peripheral tolerance. This regulatory function appears to be directly mediated by the production of IL-10 and/or TGFβ and by the ability of B cells to interact with pathogenic T cells to inhibit harmful immune responses. The identification of their existence is of great relevance to the understanding of autoimmune diseases and to the development of new therapeutic strategies." @default.
- W2065260129 created "2016-06-24" @default.
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- W2065260129 date "2008-01-01" @default.
- W2065260129 modified "2023-09-26" @default.
- W2065260129 title "The ‘short’ history of regulatory B cells" @default.
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- W2065260129 doi "https://doi.org/10.1016/j.it.2007.10.004" @default.
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