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- W2065266815 endingPage "1338" @default.
- W2065266815 startingPage "1329" @default.
- W2065266815 abstract "Introduction: IL-21, a cytokine produced by activated CD4+ cells, activated natural killer T cells and T helper cells in the germinal centers, is involved in the control of the function of both immune and parenchymal cells.Areas covered: IL-21 is overproduced in many chronic inflammatory disorders, including inflammatory bowel diseases, psoriasis, rheumatoid arthritis, type I diabetes and systemic lupus erythematosus, and studies in experimental models indicate that IL-21 plays an important role in sustaining tissue-damaging immune responses in such pathologies. However, genetic deficiency of IL-21 associates with inflammatory bowel diseases and blockade of IL-21 in the early phases exacerbates the disease progression in some models of rheumatoid arthritis and systemic lupus erythematosus, thus suggesting a dual role of IL-21 in the control of immune-mediated diseases. IL-21 can exert additional protective functions for the host as it promotes cytotoxic responses against tumors and viruses.Expert opinion: We here review the available data on the role of IL-21 in chronic inflammatory diseases and discuss the therapeutic benefit of IL-21 inhibitors in such diseases as well as the potential risks of such treatments." @default.
- W2065266815 created "2016-06-24" @default.
- W2065266815 creator A5009705533 @default.
- W2065266815 creator A5037866231 @default.
- W2065266815 creator A5042986390 @default.
- W2065266815 creator A5086858016 @default.
- W2065266815 creator A5089479928 @default.
- W2065266815 date "2014-08-27" @default.
- W2065266815 modified "2023-10-15" @default.
- W2065266815 title "IL-21 as a therapeutic target in inflammatory disorders" @default.
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