Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065272098> ?p ?o ?g. }
- W2065272098 endingPage "389" @default.
- W2065272098 startingPage "379" @default.
- W2065272098 abstract "Aims: Mutation of c‐kit is a relatively early event in the tumorigenesis of gastrointestinal stromal tumours (GISTs). The aim was to determine the prognostic significance of p53 alterations as an additional genetic change in GISTs. Methods and results: We reviewed 125 patients with localized GISTs subjected to complete resection between 1990 and 2002. Mutational analyses of c‐kit exons 9, 11, 13 and 17, p53 exons 4–8 and immunohistochemistry for p53 protein were conducted using paraffin‐embedded tissues. Alterations of p53 were observed in 50 patients (40.0%). Based on the National Institutes of Health’s risk category, p53 alterations were noted more frequently in the higher risk categories ( P = 0.041). With a median follow‐up of 56.5 months (range: 2.3–126.8), 5‐year relapse‐free survival (RFS) rates were 61.7% without p53 alterations, compared with only 40.2% with p53 alterations ( P = 0.009). Multivariate analysis indicated that p53 alterations comprised an independent, poor prognostic factor for RFS, in addition to c‐kit mutations, large size, a high mitotic count and non‐gastric primary sites. Conclusions: Alterations in p53 were more commonly observed in localized GISTs at higher risk of relapse. This suggests that they are significant as an independent, poor prognostic factor." @default.
- W2065272098 created "2016-06-24" @default.
- W2065272098 creator A5002489369 @default.
- W2065272098 creator A5005925636 @default.
- W2065272098 creator A5010893654 @default.
- W2065272098 creator A5012136068 @default.
- W2065272098 creator A5015127919 @default.
- W2065272098 creator A5015434633 @default.
- W2065272098 creator A5034764661 @default.
- W2065272098 creator A5036468538 @default.
- W2065272098 creator A5044079996 @default.
- W2065272098 creator A5050625196 @default.
- W2065272098 creator A5051777336 @default.
- W2065272098 creator A5074535143 @default.
- W2065272098 creator A5078213894 @default.
- W2065272098 creator A5085952795 @default.
- W2065272098 date "2007-08-21" @default.
- W2065272098 modified "2023-10-16" @default.
- W2065272098 title "Prognostic significance of p53 gene mutations and protein overexpression in localized gastrointestinal stromal tumours" @default.
- W2065272098 cites W1968470609 @default.
- W2065272098 cites W1970221755 @default.
- W2065272098 cites W1977617512 @default.
- W2065272098 cites W1981132188 @default.
- W2065272098 cites W1982619204 @default.
- W2065272098 cites W1983191076 @default.
- W2065272098 cites W2006182505 @default.
- W2065272098 cites W2007328596 @default.
- W2065272098 cites W2008920989 @default.
- W2065272098 cites W2012053348 @default.
- W2065272098 cites W2022167872 @default.
- W2065272098 cites W2028763294 @default.
- W2065272098 cites W2035966048 @default.
- W2065272098 cites W2042316019 @default.
- W2065272098 cites W2049137769 @default.
- W2065272098 cites W2071180498 @default.
- W2065272098 cites W2073576377 @default.
- W2065272098 cites W2074895237 @default.
- W2065272098 cites W2076470148 @default.
- W2065272098 cites W2088344791 @default.
- W2065272098 cites W2089509573 @default.
- W2065272098 cites W2094117733 @default.
- W2065272098 cites W2113954582 @default.
- W2065272098 cites W2120775866 @default.
- W2065272098 cites W2137507750 @default.
- W2065272098 cites W2140452814 @default.
- W2065272098 cites W2141762576 @default.
- W2065272098 cites W2150066245 @default.
- W2065272098 cites W2150097377 @default.
- W2065272098 cites W2155699400 @default.
- W2065272098 cites W2165902939 @default.
- W2065272098 cites W2171620774 @default.
- W2065272098 cites W3081445012 @default.
- W2065272098 doi "https://doi.org/10.1111/j.1365-2559.2007.02797.x" @default.
- W2065272098 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17727479" @default.
- W2065272098 hasPublicationYear "2007" @default.
- W2065272098 type Work @default.
- W2065272098 sameAs 2065272098 @default.
- W2065272098 citedByCount "21" @default.
- W2065272098 countsByYear W20652720982012 @default.
- W2065272098 countsByYear W20652720982014 @default.
- W2065272098 countsByYear W20652720982015 @default.
- W2065272098 countsByYear W20652720982016 @default.
- W2065272098 countsByYear W20652720982018 @default.
- W2065272098 countsByYear W20652720982019 @default.
- W2065272098 countsByYear W20652720982022 @default.
- W2065272098 crossrefType "journal-article" @default.
- W2065272098 hasAuthorship W2065272098A5002489369 @default.
- W2065272098 hasAuthorship W2065272098A5005925636 @default.
- W2065272098 hasAuthorship W2065272098A5010893654 @default.
- W2065272098 hasAuthorship W2065272098A5012136068 @default.
- W2065272098 hasAuthorship W2065272098A5015127919 @default.
- W2065272098 hasAuthorship W2065272098A5015434633 @default.
- W2065272098 hasAuthorship W2065272098A5034764661 @default.
- W2065272098 hasAuthorship W2065272098A5036468538 @default.
- W2065272098 hasAuthorship W2065272098A5044079996 @default.
- W2065272098 hasAuthorship W2065272098A5050625196 @default.
- W2065272098 hasAuthorship W2065272098A5051777336 @default.
- W2065272098 hasAuthorship W2065272098A5074535143 @default.
- W2065272098 hasAuthorship W2065272098A5078213894 @default.
- W2065272098 hasAuthorship W2065272098A5085952795 @default.
- W2065272098 hasConcept C104317684 @default.
- W2065272098 hasConcept C121608353 @default.
- W2065272098 hasConcept C126322002 @default.
- W2065272098 hasConcept C142724271 @default.
- W2065272098 hasConcept C143998085 @default.
- W2065272098 hasConcept C16930146 @default.
- W2065272098 hasConcept C204232928 @default.
- W2065272098 hasConcept C2775922572 @default.
- W2065272098 hasConcept C2994225774 @default.
- W2065272098 hasConcept C36823959 @default.
- W2065272098 hasConcept C501734568 @default.
- W2065272098 hasConcept C502942594 @default.
- W2065272098 hasConcept C54355233 @default.
- W2065272098 hasConcept C555283112 @default.
- W2065272098 hasConcept C71924100 @default.
- W2065272098 hasConcept C86803240 @default.
- W2065272098 hasConceptScore W2065272098C104317684 @default.
- W2065272098 hasConceptScore W2065272098C121608353 @default.