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• W2065273014 abstract "Oroxylin A (1), a flavonoid from the roots of Scutellaria baicalensis, increased the cellular accumulation of calcein AM in a concentration-dependent manner in NCI/ADR-RES cells overexpressing P-glycoprotein over the concentration range 0−40 μM. In addition, 1 significantly (p < 0.05) increased the cellular accumulation of paclitaxel in NCI/ADR-RES cells while it did not alter the cellular accumulation of paclitaxel in cells lacking P-glycoprotein expression. Accordingly, the concentrations that yielded 50% cytotoxicity of vinblastine and paclitaxel were reduced by approximately 5-fold in the presence of 1. This indicated that cancer cells became more susceptible to the cytotoxicity of vinblastine and paclitaxel in the presence of 1. The concomitant use of 1 (30 mg·kg−1) significantly (p < 0.05) enhanced the oral exposure of paclitaxel (15 mg·kg−1) in rats. The Cmax and AUC values of paclitaxel increased by 2.1−2.6-fold in the presence of 1 with no significant change in Tmax. In conclusion, 1 was effective in inhibiting P-glycoprotein-mediated drug efflux both in vitro and in vivo, suggesting that it may be useful to improve the cellular availability of P-glycoprotein substrates such as anticancer drugs." @default.
• W2065273014 created "2016-06-24" @default.
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• W2065273014 date "2009-09-09" @default.
• W2065273014 modified "2023-10-18" @default.
• W2065273014 title "Evaluation of the Flavonoid Oroxylin A as an Inhibitor of P-Glycoprotein-Mediated Cellular Efflux" @default.
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• W2065273014 doi "https://doi.org/10.1021/np9003036" @default.
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