Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065278462> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2065278462 endingPage "37" @default.
- W2065278462 startingPage "31" @default.
- W2065278462 abstract "The possibility that angiotensin II (AII) functions as an excitatory transmitter on sympathetic preganglionic neurones was tested in anaesthetized rats. Drugs were administered intrathecally whilst recording blood pressure, heart rate and sympathetic activity in splanchnic or renal nerves. Intrathecal AII (20 microliters, 10(-5) M) caused a significant increase in blood pressure of 13% +/- 3 and in sympathetic activity of 15% +/- 5. Intrathecal AII (20 microliters, 10(-3) M) caused larger increases in blood pressure of 22% +/- 3 and in sympathetic activity of 25% +/- 3. The magnitude of the response was dependent on the location of the catheter tip within the subarachnoid space T9-T11 being best for the above changes. Preceding intrathecal AII with the AII antagonist Saralasin (20 microliters, 10(-3) M) also given intrathecally prevented the changes. An increase in sympathetic nerve activity brought about reflexly by a drop in blood pressure of 45-47 mm Hg was almost halved by intrathecal Saralasin. Peak plasma counts (less than 5% of total) of [3H]AII in the blood after intrathecal injection occurred 2 min after the peak changes in sympathetic activity and blood pressure. Counts of [3H]AII in the spinal cord showed that 81% of recovered label was within one segment on either side of the catheter tip. It is concluded that AII has an excitatory action on sympathetic neurones in the spinal cord." @default.
- W2065278462 created "2016-06-24" @default.
- W2065278462 creator A5046405047 @default.
- W2065278462 creator A5071492909 @default.
- W2065278462 date "1987-04-01" @default.
- W2065278462 modified "2023-10-17" @default.
- W2065278462 title "Intrathecally administered angiotensin II increases sympathetic activity in the rat" @default.
- W2065278462 cites W1975005022 @default.
- W2065278462 cites W1978221400 @default.
- W2065278462 cites W1981395898 @default.
- W2065278462 cites W2000661204 @default.
- W2065278462 cites W2000687788 @default.
- W2065278462 cites W2006523728 @default.
- W2065278462 cites W2007821366 @default.
- W2065278462 cites W2010481728 @default.
- W2065278462 cites W2018362845 @default.
- W2065278462 cites W2037222215 @default.
- W2065278462 cites W2040725197 @default.
- W2065278462 cites W2042592058 @default.
- W2065278462 cites W2051817898 @default.
- W2065278462 cites W2078092107 @default.
- W2065278462 cites W2083258071 @default.
- W2065278462 cites W2093424474 @default.
- W2065278462 cites W2094753244 @default.
- W2065278462 doi "https://doi.org/10.1016/0165-1838(87)90142-1" @default.
- W2065278462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2885358" @default.
- W2065278462 hasPublicationYear "1987" @default.
- W2065278462 type Work @default.
- W2065278462 sameAs 2065278462 @default.
- W2065278462 citedByCount "39" @default.
- W2065278462 countsByYear W20652784622013 @default.
- W2065278462 countsByYear W20652784622018 @default.
- W2065278462 countsByYear W20652784622019 @default.
- W2065278462 countsByYear W20652784622020 @default.
- W2065278462 countsByYear W20652784622021 @default.
- W2065278462 countsByYear W20652784622023 @default.
- W2065278462 crossrefType "journal-article" @default.
- W2065278462 hasAuthorship W2065278462A5046405047 @default.
- W2065278462 hasAuthorship W2065278462A5071492909 @default.
- W2065278462 hasConcept C112592302 @default.
- W2065278462 hasConcept C118552586 @default.
- W2065278462 hasConcept C126322002 @default.
- W2065278462 hasConcept C134018914 @default.
- W2065278462 hasConcept C170493617 @default.
- W2065278462 hasConcept C178853913 @default.
- W2065278462 hasConcept C24998067 @default.
- W2065278462 hasConcept C2775849017 @default.
- W2065278462 hasConcept C2776533406 @default.
- W2065278462 hasConcept C2776823063 @default.
- W2065278462 hasConcept C2780661788 @default.
- W2065278462 hasConcept C2780775167 @default.
- W2065278462 hasConcept C2908929049 @default.
- W2065278462 hasConcept C42219234 @default.
- W2065278462 hasConcept C71924100 @default.
- W2065278462 hasConcept C84393581 @default.
- W2065278462 hasConceptScore W2065278462C112592302 @default.
- W2065278462 hasConceptScore W2065278462C118552586 @default.
- W2065278462 hasConceptScore W2065278462C126322002 @default.
- W2065278462 hasConceptScore W2065278462C134018914 @default.
- W2065278462 hasConceptScore W2065278462C170493617 @default.
- W2065278462 hasConceptScore W2065278462C178853913 @default.
- W2065278462 hasConceptScore W2065278462C24998067 @default.
- W2065278462 hasConceptScore W2065278462C2775849017 @default.
- W2065278462 hasConceptScore W2065278462C2776533406 @default.
- W2065278462 hasConceptScore W2065278462C2776823063 @default.
- W2065278462 hasConceptScore W2065278462C2780661788 @default.
- W2065278462 hasConceptScore W2065278462C2780775167 @default.
- W2065278462 hasConceptScore W2065278462C2908929049 @default.
- W2065278462 hasConceptScore W2065278462C42219234 @default.
- W2065278462 hasConceptScore W2065278462C71924100 @default.
- W2065278462 hasConceptScore W2065278462C84393581 @default.
- W2065278462 hasIssue "1" @default.
- W2065278462 hasLocation W20652784621 @default.
- W2065278462 hasLocation W20652784622 @default.
- W2065278462 hasOpenAccess W2065278462 @default.
- W2065278462 hasPrimaryLocation W20652784621 @default.
- W2065278462 hasRelatedWork W1968943119 @default.
- W2065278462 hasRelatedWork W2076424215 @default.
- W2065278462 hasRelatedWork W2122024141 @default.
- W2065278462 hasRelatedWork W2129470347 @default.
- W2065278462 hasRelatedWork W2171653463 @default.
- W2065278462 hasRelatedWork W2266701512 @default.
- W2065278462 hasRelatedWork W2405364540 @default.
- W2065278462 hasRelatedWork W2412038336 @default.
- W2065278462 hasRelatedWork W4255136341 @default.
- W2065278462 hasRelatedWork W18284627 @default.
- W2065278462 hasVolume "19" @default.
- W2065278462 isParatext "false" @default.
- W2065278462 isRetracted "false" @default.
- W2065278462 magId "2065278462" @default.
- W2065278462 workType "article" @default.