FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065302641> ?p ?o ?g. }

• W2065302641 endingPage "449" @default.
• W2065302641 startingPage "444" @default.
• W2065302641 abstract "MicroRNAs (miRNAs) are regulators of numerous cellular events; accumulating evidence indicates that miRNAs play a key role in a wide range of biological functions, such as cellular proliferation, differentiation, and apoptosis in cancer. Down-regulated expression of miR-145 has been reported in colon cancer tissues and cell lines. The molecular mechanisms underlying miR-145 and the regulation of colon carcinogenesis remain unclear. In this study, we investigated the levels of miR-145 in human colon cancer cells using qRT-PCR and found markedly decreased levels compared to normal epithelial cells. We identified PAK4 as a novel target of miR-145 using informatics screening. Additionally, we demonstrated that miR-145 targets a putative binding site in the 3′UTR of PAK4 and that its abundance is inversely associated with miR-145 expression in colon cancer cells; we confirmed this relationship using the luciferase reporter assay. Furthermore, restoration of miR-145 by mimics in SW620 cells significantly attenuated cell growth in vitro, in accordance with the inhibitory effects induced by siRNA mediated knockdown of PAK4. Taken together, these findings demonstrate that miR-145 downregulates P-ERK expression by targeting PAK4 and leads to inhibition of tumor growth." @default.
• W2065302641 created "2016-06-24" @default.
• W2065302641 creator A5028467654 @default.
• W2065302641 creator A5040135272 @default.
• W2065302641 creator A5045158950 @default.
• W2065302641 creator A5050439687 @default.
• W2065302641 creator A5060185042 @default.
• W2065302641 creator A5062993098 @default.
• W2065302641 creator A5069057734 @default.
• W2065302641 creator A5087891437 @default.
• W2065302641 date "2012-10-01" @default.
• W2065302641 modified "2023-09-30" @default.
• W2065302641 title "MiR-145 regulates PAK4 via the MAPK pathway and exhibits an antitumor effect in human colon cells" @default.
• W2065302641 cites W1963691340 @default.
• W2065302641 cites W1970583256 @default.
• W2065302641 cites W1971463658 @default.
• W2065302641 cites W1996630410 @default.
• W2065302641 cites W2002995168 @default.
• W2065302641 cites W2013721931 @default.
• W2065302641 cites W2015858554 @default.
• W2065302641 cites W2022593383 @default.
• W2065302641 cites W2025646149 @default.
• W2065302641 cites W2027025742 @default.
• W2065302641 cites W2034608727 @default.
• W2065302641 cites W2042870337 @default.
• W2065302641 cites W2043103956 @default.
• W2065302641 cites W2048603557 @default.
• W2065302641 cites W2049804522 @default.
• W2065302641 cites W2056147363 @default.
• W2065302641 cites W2090034342 @default.
• W2065302641 cites W2099692224 @default.
• W2065302641 cites W2103164402 @default.
• W2065302641 cites W2111783800 @default.
• W2065302641 cites W2122271136 @default.
• W2065302641 cites W2127080020 @default.
• W2065302641 cites W2130979840 @default.
• W2065302641 cites W2137850244 @default.
• W2065302641 cites W2142360849 @default.
• W2065302641 cites W2150536104 @default.
• W2065302641 cites W2154295458 @default.
• W2065302641 cites W2157754963 @default.
• W2065302641 cites W2159083300 @default.
• W2065302641 cites W2164335165 @default.
• W2065302641 cites W2165948908 @default.
• W2065302641 cites W2171559697 @default.
• W2065302641 cites W4237473415 @default.
• W2065302641 doi "https://doi.org/10.1016/j.bbrc.2012.06.123" @default.
• W2065302641 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22766504" @default.
• W2065302641 hasPublicationYear "2012" @default.
• W2065302641 type Work @default.
• W2065302641 sameAs 2065302641 @default.
• W2065302641 citedByCount "63" @default.
• W2065302641 countsByYear W20653026412013 @default.
• W2065302641 countsByYear W20653026412014 @default.
• W2065302641 countsByYear W20653026412015 @default.
• W2065302641 countsByYear W20653026412016 @default.
• W2065302641 countsByYear W20653026412017 @default.
• W2065302641 countsByYear W20653026412018 @default.
• W2065302641 countsByYear W20653026412019 @default.
• W2065302641 countsByYear W20653026412020 @default.
• W2065302641 countsByYear W20653026412021 @default.
• W2065302641 countsByYear W20653026412022 @default.
• W2065302641 countsByYear W20653026412023 @default.
• W2065302641 crossrefType "journal-article" @default.
• W2065302641 hasAuthorship W2065302641A5028467654 @default.
• W2065302641 hasAuthorship W2065302641A5040135272 @default.
• W2065302641 hasAuthorship W2065302641A5045158950 @default.
• W2065302641 hasAuthorship W2065302641A5050439687 @default.
• W2065302641 hasAuthorship W2065302641A5060185042 @default.
• W2065302641 hasAuthorship W2065302641A5062993098 @default.
• W2065302641 hasAuthorship W2065302641A5069057734 @default.
• W2065302641 hasAuthorship W2065302641A5087891437 @default.
• W2065302641 hasConcept C104317684 @default.
• W2065302641 hasConcept C111335760 @default.
• W2065302641 hasConcept C121608353 @default.
• W2065302641 hasConcept C145059251 @default.
• W2065302641 hasConcept C173396325 @default.
• W2065302641 hasConcept C185592680 @default.
• W2065302641 hasConcept C190283241 @default.
• W2065302641 hasConcept C502942594 @default.
• W2065302641 hasConcept C526805850 @default.
• W2065302641 hasConcept C54009773 @default.
• W2065302641 hasConcept C54355233 @default.
• W2065302641 hasConcept C55493867 @default.
• W2065302641 hasConcept C555283112 @default.
• W2065302641 hasConcept C57074206 @default.
• W2065302641 hasConcept C62112901 @default.
• W2065302641 hasConcept C62478195 @default.
• W2065302641 hasConcept C81885089 @default.
• W2065302641 hasConcept C86803240 @default.
• W2065302641 hasConcept C95444343 @default.
• W2065302641 hasConceptScore W2065302641C104317684 @default.
• W2065302641 hasConceptScore W2065302641C111335760 @default.
• W2065302641 hasConceptScore W2065302641C121608353 @default.
• W2065302641 hasConceptScore W2065302641C145059251 @default.
• W2065302641 hasConceptScore W2065302641C173396325 @default.
• W2065302641 hasConceptScore W2065302641C185592680 @default.
• W2065302641 hasConceptScore W2065302641C190283241 @default.

• next