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- W2065308144 abstract "We have examined the MCR and production rate (PR) of 3′,5′-diiodothyronine (3′,5′-T2) in states of altered thyroid function. Although the major thrust of these studies was to examine the metabolism of [125I]3′,5′-T2 in hyperthyroid and hypothyroid subjects and in athyreotic patients receiving L-T4 replacement, a second aspect of the study was to determine whether infusions of unlabeled 3′,5′-T2 yielded results comparable to those obtained by radiolabeled infusions. Serum 3′,5′-T2 concentrations(mean ± SE) were 8.4 ± 1.1 ng/dl in five hyperthyroid, 7.2 ± 0.4 ng⁄dl in five T4-replaced, and less than 2.0 ng⁄ dl in five hypothyroid subjects. The MCRs (mean ± SE) determined by [125I]3′,5′-T2 infusions differed significantly among groups and were 448 ± 23, 354 ± 23, and 251 ± 17 liters⁄70 kg day in the hyperthyroid, T4-replaced, and hypothyroid groups, respectively. When infusions were performed in the same patients using unlabeled 3′,5′-T2, the results were 463 ± 29, 360 ± 21, and 245 ± 8 liters/70 kg day. The..." @default.
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- W2065308144 date "1981-04-01" @default.
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- W2065308144 title "Metabolic Clearance and Production Rates of 3′,5′-Diiodothyronine in Hyperthyroidism and Hypothyroidism in Man: Comparison of Infusions Using Radiolabeled Versus Unlabeled Iodothyronine*" @default.
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- W2065308144 doi "https://doi.org/10.1210/jcem-52-4-722" @default.
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