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- W2065317468 abstract "Summary The terminal differentiation of melanocytes is associated with the transcriptional activation of genes responsible for pigment production such as tyrosinase. Pigment cell‐specific transcription factors, such as Mitf, as well as specific proximal and distal regulatory elements (DRE) are implicated in the tight control of tyrosinase expression during development and adulthood. Proper tyrosinase expression in melanocytes depends upon the presence of a DRE that is located at −15 kb and provides enhancer activity via a central element termed core‐enhancer. In this report, we show that the transcription factors Sox10, Mitf and USF‐1 are able to activate the core‐enhancer in luciferase reporter assays. Comparative sequence analysis identified evolutionarily motifs resembling Sox10 binding sites that were required for full enhancer activity in melanoma cells and in tyrosinase::lacZ transgenic mice. Sox10 was able to bind the DRE in vitro and mutation of the conserved motifs abolished the enhancer transactivation mediated by Sox10. In addition, two highly conserved CAGCTG E‐box motifs were identified that were also required for enhancer activity and for transactivation by Mitf. The results suggest that Sox10 directly, and Mitf, most likely indirectly, activate the tyrosinase enhancer, underlining the contribution of Sox10 to tyrosinase gene regulation in melanocytes." @default.
- W2065317468 created "2016-06-24" @default.
- W2065317468 creator A5053617882 @default.
- W2065317468 creator A5080334797 @default.
- W2065317468 creator A5083677420 @default.
- W2065317468 date "2007-03-16" @default.
- W2065317468 modified "2023-09-30" @default.
- W2065317468 title "The tyrosinase enhancer is activated by Sox10 and Mitf in mouse melanocytes" @default.
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- W2065317468 doi "https://doi.org/10.1111/j.1600-0749.2007.00368.x" @default.
- W2065317468 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17516925" @default.
- W2065317468 hasPublicationYear "2007" @default.
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