FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065326056> ?p ?o ?g. }

• W2065326056 endingPage "143" @default.
• W2065326056 startingPage "137" @default.
• W2065326056 abstract "Triggering receptor expressed on myeloid cells-1 (TREM-1) is highly expressed in inflammatory lesions caused by infectious agents such as bacteria and fungi but not in normal tissues or non-infectious lesions. There is evidence that macrolide antibiotics can act as immunomodulatory agents. The purpose of the current study was to determine whether azithromycin, a type of macrolide antibiotic, could reduce the expression of TREM-1 in Bacillus pyocyaneus-induced sepsis in vitro and in vivo. We treated THP-1 cells with LPS, LPS+TREM-1/Fc, and LPS+azithromycin for in vitro study. A B. pyocyaneus pyemia animal model was developed for in vivo study. RT-PCR, western blotting, and flow cytometry (FCM) were employed to determine the expression of TREM-1. ELISA analysis was utilized to examine the concentration of cytokines. Our results showed that azithromycin treatment did not reduce the level of LPS-induced TREM-1 mRNA in THP-1 cells. However, treatment with TREM-1/Fc fusion protein or azithromycin reduced the effect of LPS-stimulated TREM-1 protein expression. The expression of inflammatory factors (TNF-α, IL-6, and IL-1β) in cell culture supernatant and mouse serum of the TREM-1/Fc fusion protein-treated and azithromycin-treated groups were lower than that of the control group (p<0.05). The results from the animal sepsis model experiments demonstrated that the TREM-1 Fc/fusion protein and azithromycin treatment groups' survival rates were significantly higher than in the control group. Analysis of serum inflammatory factors in septic mice revealed that the concentration of these factors was significantly lower than in the control group. Our results furthered the understanding of azithromycin function in immunological regulation and provided reliable data for new clinical applications." @default.
• W2065326056 created "2016-06-24" @default.
• W2065326056 creator A5002139784 @default.
• W2065326056 creator A5007618565 @default.
• W2065326056 creator A5008222714 @default.
• W2065326056 date "2011-08-01" @default.
• W2065326056 modified "2023-09-25" @default.
• W2065326056 title "Azithromycin acts as an immunomodulatory agent to suppress the expression of TREM-1 in Bacillus pyocyaneus-induced sepsis" @default.
• W2065326056 cites W1557825564 @default.
• W2065326056 cites W1601476460 @default.
• W2065326056 cites W1643888758 @default.
• W2065326056 cites W1954536264 @default.
• W2065326056 cites W1970356010 @default.
• W2065326056 cites W1977047743 @default.
• W2065326056 cites W1982645038 @default.
• W2065326056 cites W1986899130 @default.
• W2065326056 cites W1990271799 @default.
• W2065326056 cites W1993170419 @default.
• W2065326056 cites W2012539089 @default.
• W2065326056 cites W2012846629 @default.
• W2065326056 cites W2033028058 @default.
• W2065326056 cites W2042419273 @default.
• W2065326056 cites W2047907938 @default.
• W2065326056 cites W2050582522 @default.
• W2065326056 cites W2057309531 @default.
• W2065326056 cites W2057704272 @default.
• W2065326056 cites W2059038780 @default.
• W2065326056 cites W2066332911 @default.
• W2065326056 cites W2090648579 @default.
• W2065326056 cites W2097582396 @default.
• W2065326056 cites W2101316389 @default.
• W2065326056 cites W2102389257 @default.
• W2065326056 cites W2105903244 @default.
• W2065326056 cites W2114829829 @default.
• W2065326056 cites W2126525190 @default.
• W2065326056 cites W2128413447 @default.
• W2065326056 cites W2131455890 @default.
• W2065326056 cites W2138885527 @default.
• W2065326056 cites W2140270184 @default.
• W2065326056 cites W2145331408 @default.
• W2065326056 cites W2149698238 @default.
• W2065326056 cites W2155533398 @default.
• W2065326056 cites W2156153766 @default.
• W2065326056 cites W2171405214 @default.
• W2065326056 doi "https://doi.org/10.1016/j.imlet.2011.04.001" @default.
• W2065326056 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21507332" @default.
• W2065326056 hasPublicationYear "2011" @default.
• W2065326056 type Work @default.
• W2065326056 sameAs 2065326056 @default.
• W2065326056 citedByCount "15" @default.
• W2065326056 countsByYear W20653260562012 @default.
• W2065326056 countsByYear W20653260562013 @default.
• W2065326056 countsByYear W20653260562014 @default.
• W2065326056 countsByYear W20653260562015 @default.
• W2065326056 countsByYear W20653260562017 @default.
• W2065326056 countsByYear W20653260562020 @default.
• W2065326056 countsByYear W20653260562021 @default.
• W2065326056 countsByYear W20653260562022 @default.
• W2065326056 countsByYear W20653260562023 @default.
• W2065326056 crossrefType "journal-article" @default.
• W2065326056 hasAuthorship W2065326056A5002139784 @default.
• W2065326056 hasAuthorship W2065326056A5007618565 @default.
• W2065326056 hasAuthorship W2065326056A5008222714 @default.
• W2065326056 hasConcept C104317684 @default.
• W2065326056 hasConcept C123894998 @default.
• W2065326056 hasConcept C150903083 @default.
• W2065326056 hasConcept C17991360 @default.
• W2065326056 hasConcept C202751555 @default.
• W2065326056 hasConcept C203014093 @default.
• W2065326056 hasConcept C207001950 @default.
• W2065326056 hasConcept C2778384902 @default.
• W2065326056 hasConcept C2778754761 @default.
• W2065326056 hasConcept C2778907293 @default.
• W2065326056 hasConcept C40767141 @default.
• W2065326056 hasConcept C501593827 @default.
• W2065326056 hasConcept C553184892 @default.
• W2065326056 hasConcept C55493867 @default.
• W2065326056 hasConcept C86803240 @default.
• W2065326056 hasConcept C89423630 @default.
• W2065326056 hasConcept C98274493 @default.
• W2065326056 hasConceptScore W2065326056C104317684 @default.
• W2065326056 hasConceptScore W2065326056C123894998 @default.
• W2065326056 hasConceptScore W2065326056C150903083 @default.
• W2065326056 hasConceptScore W2065326056C17991360 @default.
• W2065326056 hasConceptScore W2065326056C202751555 @default.
• W2065326056 hasConceptScore W2065326056C203014093 @default.
• W2065326056 hasConceptScore W2065326056C207001950 @default.
• W2065326056 hasConceptScore W2065326056C2778384902 @default.
• W2065326056 hasConceptScore W2065326056C2778754761 @default.
• W2065326056 hasConceptScore W2065326056C2778907293 @default.
• W2065326056 hasConceptScore W2065326056C40767141 @default.
• W2065326056 hasConceptScore W2065326056C501593827 @default.
• W2065326056 hasConceptScore W2065326056C553184892 @default.
• W2065326056 hasConceptScore W2065326056C55493867 @default.
• W2065326056 hasConceptScore W2065326056C86803240 @default.
• W2065326056 hasConceptScore W2065326056C89423630 @default.
• W2065326056 hasConceptScore W2065326056C98274493 @default.
• W2065326056 hasFunder F4320321001 @default.

• next