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• W2065327999 abstract "Tumour necrosis factor-alpha (TNF-alpha) was able to promote collagen breakdown from bovine cartilage in explant culture. This release was dependent upon matrix metalloproteinases (MMPs) and could be prevented by transforming growth factor-beta1 (TGF-beta1) or insulin-like growth factor-1. Both growth factors reduced the expression and secretion of collagenase enzymes, and TGF-beta1 induced tissue inhibitor of metalloproteinase production. This study shows for the first time that these anabolic growth factors can protect cartilage against TNF-alpha-induced destruction." @default.
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• W2065327999 date "2001-10-01" @default.
• W2065327999 modified "2023-09-27" @default.
• W2065327999 title "MODULATION OF THE EXPRESSION OF MATRIX METALLOPROTEINASE AND TISSUE INHIBITORS OF METALLOPROTEINASES BY TGF-β1 AND IGF-1 IN PRIMARY HUMAN ARTICULAR AND BOVINE NASAL CHONDROCYTES STIMULATED WITH TNF-α" @default.
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• W2065327999 doi "https://doi.org/10.1006/cyto.2001.0950" @default.
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