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- W2065343824 abstract "The case of a patient with a 3 year long illness characterized by episodic localized lymphadenitis and concurrent acute autoimmune hemolytic anemia is reported. Histopathologically the lymphoid disease was granulomatous necrotizing vasculitis of the Wegener type. The acute hemolysis occurring with these episodes was associated with extreme erythrophagocytosis in the peripheral blood without hemoglobinuria. The unique autoantibody resembled the cold agglutinins of lymphoproliferative diseases in that it was an immunoglobulin M (IgM) with only kappa light chains and had anti-I specificity. However, the antibody had no agglutinating ability, demonstrated biphasic thermal requirements for in vitro hemolysis (cold, then warm, incubation) and was of approximately 7S size. Despite the requirement for incubation at less than 10 °C to produce in vitro hemolysis, clinical episodes of severe hemolytic anemia were unassociated with cold exposure. An excellent response to cortico-steroids contrasted with the typical experience with cold-reacting red cell autoantibodies." @default.
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- W2065343824 date "1974-03-01" @default.
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- W2065343824 title "Acute autoimmune hemolytic anemia due to a low molecular weight IgM cold hemolysin associated with episodic lymphoid granulomatous vasculitis" @default.
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- W2065343824 doi "https://doi.org/10.1016/0002-9343(74)90625-1" @default.
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