Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065345621> ?p ?o ?g. }
- W2065345621 abstract "Induction of immune tolerance is a key process by which the immune system is educated to modulate reactions against benign stimuli such as self-antigens and commensal microbes. Understanding and harnessing the natural mechanisms of immune tolerance may become an increasingly useful strategy for treating many types of allergic and autoimmune diseases, as well as for improving the acceptance of solid organ transplants. Our laboratory and others have been interested in the natural ability of some B lymphocytes to express the death-inducing molecule Fas ligand (FasL), and their ability to kill T helper (TH) lymphocytes. We have recently shown that experimental transformation of human B cells by a non-replicative variant of Epstein-Barr virus (EBV) consistently resulted in high expression of functional FasL protein. The production and release of FasL+ exosomes that co-expressed MHC Class II molecules and had the capacity to kill antigen-specific TH cells was also observed. Several lines of evidence indicate that FasL+ B cells and FasL+MHCII+ exosomes have important roles in natural immune tolerance and have a great deal of therapeutic potential. Taken together, these findings suggest that EBV-immortalized human B lymphoblastoid cell lines could be used as cellular factories for FasL+ exosomes, which would be employed to therapeutically establish and/or regain immune tolerance toward specific antigens. The goals of this review are to summarize current knowledge of the roles of FasL+ B cells and exosomes in immune regulation, and to suggest methods of manipulating killer B cells and FasL+ exosomes for clinical purposes." @default.
- W2065345621 created "2016-06-24" @default.
- W2065345621 creator A5011126910 @default.
- W2065345621 creator A5025044565 @default.
- W2065345621 creator A5037364245 @default.
- W2065345621 date "2015-03-20" @default.
- W2065345621 modified "2023-09-25" @default.
- W2065345621 title "Killer B Lymphocytes and Their Fas Ligand Positive Exosomes as Inducers of Immune Tolerance" @default.
- W2065345621 cites W12758739 @default.
- W2065345621 cites W1510212726 @default.
- W2065345621 cites W1512851684 @default.
- W2065345621 cites W1567676800 @default.
- W2065345621 cites W1585132230 @default.
- W2065345621 cites W1586923479 @default.
- W2065345621 cites W1615139577 @default.
- W2065345621 cites W1616108185 @default.
- W2065345621 cites W1653373310 @default.
- W2065345621 cites W1655756854 @default.
- W2065345621 cites W1660842594 @default.
- W2065345621 cites W1749515626 @default.
- W2065345621 cites W1794768229 @default.
- W2065345621 cites W1833105288 @default.
- W2065345621 cites W1900665661 @default.
- W2065345621 cites W1963640511 @default.
- W2065345621 cites W1964086838 @default.
- W2065345621 cites W1966740101 @default.
- W2065345621 cites W1970358754 @default.
- W2065345621 cites W1971161116 @default.
- W2065345621 cites W1973569881 @default.
- W2065345621 cites W1973988039 @default.
- W2065345621 cites W1974351164 @default.
- W2065345621 cites W1974687540 @default.
- W2065345621 cites W1975291295 @default.
- W2065345621 cites W1978018492 @default.
- W2065345621 cites W1987042844 @default.
- W2065345621 cites W1991212304 @default.
- W2065345621 cites W1992863152 @default.
- W2065345621 cites W2001890567 @default.
- W2065345621 cites W2003604887 @default.
- W2065345621 cites W2006294701 @default.
- W2065345621 cites W2014179704 @default.
- W2065345621 cites W2015610860 @default.
- W2065345621 cites W2018837825 @default.
- W2065345621 cites W2019648925 @default.
- W2065345621 cites W2019824677 @default.
- W2065345621 cites W2022794974 @default.
- W2065345621 cites W2025755006 @default.
- W2065345621 cites W2027424073 @default.
- W2065345621 cites W2035502147 @default.
- W2065345621 cites W2039194398 @default.
- W2065345621 cites W2043027238 @default.
- W2065345621 cites W2053889945 @default.
- W2065345621 cites W2057179363 @default.
- W2065345621 cites W2058404073 @default.
- W2065345621 cites W2060609161 @default.
- W2065345621 cites W2060975950 @default.
- W2065345621 cites W2063445030 @default.
- W2065345621 cites W2065413461 @default.
- W2065345621 cites W2065727164 @default.
- W2065345621 cites W2067044581 @default.
- W2065345621 cites W2067385303 @default.
- W2065345621 cites W2068551464 @default.
- W2065345621 cites W2069306383 @default.
- W2065345621 cites W2070686135 @default.
- W2065345621 cites W2071547490 @default.
- W2065345621 cites W2074244815 @default.
- W2065345621 cites W2074632761 @default.
- W2065345621 cites W2076656122 @default.
- W2065345621 cites W2079971239 @default.
- W2065345621 cites W2086080135 @default.
- W2065345621 cites W2087562882 @default.
- W2065345621 cites W2092074282 @default.
- W2065345621 cites W2093038807 @default.
- W2065345621 cites W2094774569 @default.
- W2065345621 cites W2095424877 @default.
- W2065345621 cites W2096185404 @default.
- W2065345621 cites W2098525597 @default.
- W2065345621 cites W2102359228 @default.
- W2065345621 cites W2103215322 @default.
- W2065345621 cites W2104330540 @default.
- W2065345621 cites W2106545917 @default.
- W2065345621 cites W2107452159 @default.
- W2065345621 cites W2107455390 @default.
- W2065345621 cites W2109310212 @default.
- W2065345621 cites W2114040130 @default.
- W2065345621 cites W2115130133 @default.
- W2065345621 cites W2116216576 @default.
- W2065345621 cites W2121725913 @default.
- W2065345621 cites W2127993518 @default.
- W2065345621 cites W2133063407 @default.
- W2065345621 cites W2138089505 @default.
- W2065345621 cites W2140821709 @default.
- W2065345621 cites W2141646454 @default.
- W2065345621 cites W2142705391 @default.
- W2065345621 cites W2143436758 @default.
- W2065345621 cites W2154548766 @default.
- W2065345621 cites W2155366992 @default.
- W2065345621 cites W2166053801 @default.
- W2065345621 cites W2168945225 @default.
- W2065345621 cites W2218349473 @default.