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- W2065349230 abstract "Objective To investigate morphometrically the relationship between the degree of inflammatory reaction and arterial cross-sectional dimensions in giant cell arteritis (GCA). Methods The media and intima of cross-sectioned inflamed arteries from GCA patients were outlined. The media circumference and the media and intima cross-sectional areas were measured. The two segments in every biopsy displaying the least and most widespread media inflammation were compared, using a paired Student's t-test. Moreover, paired comparisons were made of the intima area in inflamed and noninflamed sectors in single cross-sections. Results The segment in each biopsy showing the most widespread media inflammation had the largest circumference and volume of media and intima; the intima cross-sectional area increased disproportionately. The intima was thickest in inflamed sectors in single cross-sections. Conclusion The close spatial correlation between inflammatory media infiltration and the marked intimal expansion supports the contention that promoting factors produced by inflammatory cells play a pathogenetic role in GCA." @default.
- W2065349230 created "2016-06-24" @default.
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- W2065349230 date "2000-10-01" @default.
- W2065349230 modified "2023-09-23" @default.
- W2065349230 title "Vessel wall morphometry in giant cell arteritis" @default.
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- W2065349230 doi "https://doi.org/10.1002/1529-0131(200010)13:5<286::aid-anr7>3.0.co;2-m" @default.
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