FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065350018> ?p ?o ?g. }

• W2065350018 endingPage "982" @default.
• W2065350018 startingPage "974" @default.
• W2065350018 abstract "LIM and SH3 protein (LASP-1), initially identified from human breast cancer, is a specific focal adhesion protein involved in cell migration. LASP-1 is an actin binding protein, which also interacts with the proline-rich domains of zyxin, a scaffolding protein required for cell movement and gene transcription. In the present work, we analyzed the effect of LASP-1 on different human breast cancer cell lines. Transfection with LASP-1-specific siRNA resulted in a reduced protein level of LASP-1 in BT-20 and MCF-7 cell lines. The siRNA-treated cells were arrested in G2/M phase of cell cycle, and proliferation of the tumor cells was suppressed by 30–50% corresponding to around 50% of the cells being transfected successfully as seen by immunofluorescence. In addition, tumor cells showed a 50% reduced migration after siRNA treatment, while overexpression of LASP-1 in non-tumor PTK-2 cells, which do not express endogenous LASP-1, resulted in a significant increase in cell motility. LASP-1 silencing is accompanied with a reduced binding of the of LASP-1 binding partner zyxin to focal contacts without changes in actin stress fiber organization as observed in immunofluorescence experiments. The data provide evidence for an essential role of LASP-1 in tumor cell growth and migration, possibly by influencing the localization of zyxin." @default.
• W2065350018 created "2016-06-24" @default.
• W2065350018 creator A5010237107 @default.
• W2065350018 creator A5027603458 @default.
• W2065350018 creator A5046234393 @default.
• W2065350018 creator A5054575121 @default.
• W2065350018 creator A5058817262 @default.
• W2065350018 creator A5072731419 @default.
• W2065350018 creator A5077575730 @default.
• W2065350018 date "2006-04-01" @default.
• W2065350018 modified "2023-09-24" @default.
• W2065350018 title "Silencing of LASP-1 influences zyxin localization, inhibits proliferation and reduces migration in breast cancer cells" @default.
• W2065350018 cites W107909901 @default.
• W2065350018 cites W1967737505 @default.
• W2065350018 cites W1972785704 @default.
• W2065350018 cites W1990397681 @default.
• W2065350018 cites W1990988819 @default.
• W2065350018 cites W2009128174 @default.
• W2065350018 cites W2010397777 @default.
• W2065350018 cites W2013054556 @default.
• W2065350018 cites W2024862370 @default.
• W2065350018 cites W2027944956 @default.
• W2065350018 cites W2044697616 @default.
• W2065350018 cites W2058800151 @default.
• W2065350018 cites W2060156100 @default.
• W2065350018 cites W2063220206 @default.
• W2065350018 cites W2085547508 @default.
• W2065350018 cites W2087240811 @default.
• W2065350018 cites W2106026577 @default.
• W2065350018 cites W2111683138 @default.
• W2065350018 cites W2116895550 @default.
• W2065350018 cites W2126728727 @default.
• W2065350018 cites W2130110320 @default.
• W2065350018 cites W2132457979 @default.
• W2065350018 cites W2137079116 @default.
• W2065350018 cites W2138484345 @default.
• W2065350018 cites W2176579253 @default.
• W2065350018 cites W2321112275 @default.
• W2065350018 doi "https://doi.org/10.1016/j.yexcr.2005.12.016" @default.
• W2065350018 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16430883" @default.
• W2065350018 hasPublicationYear "2006" @default.
• W2065350018 type Work @default.
• W2065350018 sameAs 2065350018 @default.
• W2065350018 citedByCount "107" @default.
• W2065350018 countsByYear W20653500182012 @default.
• W2065350018 countsByYear W20653500182013 @default.
• W2065350018 countsByYear W20653500182014 @default.
• W2065350018 countsByYear W20653500182015 @default.
• W2065350018 countsByYear W20653500182016 @default.
• W2065350018 countsByYear W20653500182017 @default.
• W2065350018 countsByYear W20653500182018 @default.
• W2065350018 countsByYear W20653500182019 @default.
• W2065350018 countsByYear W20653500182020 @default.
• W2065350018 countsByYear W20653500182021 @default.
• W2065350018 countsByYear W20653500182022 @default.
• W2065350018 crossrefType "journal-article" @default.
• W2065350018 hasAuthorship W2065350018A5010237107 @default.
• W2065350018 hasAuthorship W2065350018A5027603458 @default.
• W2065350018 hasAuthorship W2065350018A5046234393 @default.
• W2065350018 hasAuthorship W2065350018A5054575121 @default.
• W2065350018 hasAuthorship W2065350018A5058817262 @default.
• W2065350018 hasAuthorship W2065350018A5072731419 @default.
• W2065350018 hasAuthorship W2065350018A5077575730 @default.
• W2065350018 hasConcept C104317684 @default.
• W2065350018 hasConcept C119056186 @default.
• W2065350018 hasConcept C137738243 @default.
• W2065350018 hasConcept C1491633281 @default.
• W2065350018 hasConcept C151166631 @default.
• W2065350018 hasConcept C29537977 @default.
• W2065350018 hasConcept C502942594 @default.
• W2065350018 hasConcept C54009773 @default.
• W2065350018 hasConcept C54355233 @default.
• W2065350018 hasConcept C55493867 @default.
• W2065350018 hasConcept C62112901 @default.
• W2065350018 hasConcept C62478195 @default.
• W2065350018 hasConcept C81885089 @default.
• W2065350018 hasConcept C85789140 @default.
• W2065350018 hasConcept C86803240 @default.
• W2065350018 hasConcept C95444343 @default.
• W2065350018 hasConceptScore W2065350018C104317684 @default.
• W2065350018 hasConceptScore W2065350018C119056186 @default.
• W2065350018 hasConceptScore W2065350018C137738243 @default.
• W2065350018 hasConceptScore W2065350018C1491633281 @default.
• W2065350018 hasConceptScore W2065350018C151166631 @default.
• W2065350018 hasConceptScore W2065350018C29537977 @default.
• W2065350018 hasConceptScore W2065350018C502942594 @default.
• W2065350018 hasConceptScore W2065350018C54009773 @default.
• W2065350018 hasConceptScore W2065350018C54355233 @default.
• W2065350018 hasConceptScore W2065350018C55493867 @default.
• W2065350018 hasConceptScore W2065350018C62112901 @default.
• W2065350018 hasConceptScore W2065350018C62478195 @default.
• W2065350018 hasConceptScore W2065350018C81885089 @default.
• W2065350018 hasConceptScore W2065350018C85789140 @default.
• W2065350018 hasConceptScore W2065350018C86803240 @default.
• W2065350018 hasConceptScore W2065350018C95444343 @default.
• W2065350018 hasIssue "7" @default.
• W2065350018 hasLocation W20653500181 @default.
• W2065350018 hasLocation W20653500182 @default.

• next