FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065351371> ?p ?o ?g. }

• W2065351371 endingPage "202" @default.
• W2065351371 startingPage "193" @default.
• W2065351371 abstract "Intestinal epithelial cells (IECs) can produce cytokines and chemokines that play an important role in the mucosal immune response. Regulation of this production is important to prevent inflammatory tissue damage. The root and stem barks of Acanthopanax species have been used as a tonic and sedative as well as in the treatment of rheumatism and diabetes. The aim of this study was to examine the inhibitory effect of acanthoic acid isolated from Acanthopanax koreanum (Araliaceae), on IL-8 production via mitogen-activated protein kinases (MAPKs) and nuclear factor-kappa B (NF-kappaB) in TNF-alpha-stimulated human colon epithelial cells.HT29 cells were stimulated with TNF-alpha in the presence or absence of acanthoic acid. IL-8 production was measured by enzyme-linked immunosorbent assay (ELISA) and reverse transcription-PCR (RT-PCR). MAPK activation and IkappaB/NF-kappaB expression were assessed by Western blot analysis. NF-kappaB activation was determined using immunofluorescence localization and electrophoretic mobility shift assay (EMSA).Acanthoic acid suppressed TNF-alpha-induced IL-8 production in a dose-dependent manner. Furthermore, acanthoic acid inhibited TNF-alpha-induced MAPKs (p38, JNK1/2, and ERK1/2) activation, IkappaB degradation, NF-kappaB nuclear translocation, and NF-kappaB/DNA binding activity.Acanthoic acid might inhibit TNF-alpha-mediated IL-8 production by blocking in both the MAPKs and NF-kappaB pathways in HT29 cells." @default.
• W2065351371 created "2016-06-24" @default.
• W2065351371 creator A5001973760 @default.
• W2065351371 creator A5011637777 @default.
• W2065351371 creator A5023307227 @default.
• W2065351371 creator A5032408859 @default.
• W2065351371 creator A5039325507 @default.
• W2065351371 creator A5047504790 @default.
• W2065351371 creator A5048511516 @default.
• W2065351371 creator A5054998515 @default.
• W2065351371 creator A5058177669 @default.
• W2065351371 creator A5061178178 @default.
• W2065351371 creator A5075150288 @default.
• W2065351371 date "2004-04-01" @default.
• W2065351371 modified "2023-09-26" @default.
• W2065351371 title "Acanthoic acid inhibits IL-8 production via MAPKs and NF-κB in a TNF-α-stimulated human intestinal epithelial cell line" @default.
• W2065351371 cites W1524470153 @default.
• W2065351371 cites W1976174932 @default.
• W2065351371 cites W1986242902 @default.
• W2065351371 cites W1987135385 @default.
• W2065351371 cites W1987602796 @default.
• W2065351371 cites W1993875078 @default.
• W2065351371 cites W1994099910 @default.
• W2065351371 cites W2006219739 @default.
• W2065351371 cites W2019690306 @default.
• W2065351371 cites W2020300507 @default.
• W2065351371 cites W2043089015 @default.
• W2065351371 cites W2050318359 @default.
• W2065351371 cites W2060226981 @default.
• W2065351371 cites W2061562327 @default.
• W2065351371 cites W2063505951 @default.
• W2065351371 cites W2073542147 @default.
• W2065351371 cites W2077189992 @default.
• W2065351371 cites W2087090420 @default.
• W2065351371 cites W2107754488 @default.
• W2065351371 cites W2146895894 @default.
• W2065351371 cites W2166059675 @default.
• W2065351371 cites W2341049818 @default.
• W2065351371 cites W2470958919 @default.
• W2065351371 cites W4313347802 @default.
• W2065351371 cites W4313377080 @default.
• W2065351371 doi "https://doi.org/10.1016/j.cccn.2004.01.004" @default.
• W2065351371 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15026281" @default.
• W2065351371 hasPublicationYear "2004" @default.
• W2065351371 type Work @default.
• W2065351371 sameAs 2065351371 @default.
• W2065351371 citedByCount "29" @default.
• W2065351371 countsByYear W20653513712012 @default.
• W2065351371 countsByYear W20653513712013 @default.
• W2065351371 countsByYear W20653513712014 @default.
• W2065351371 countsByYear W20653513712015 @default.
• W2065351371 countsByYear W20653513712016 @default.
• W2065351371 countsByYear W20653513712020 @default.
• W2065351371 countsByYear W20653513712021 @default.
• W2065351371 countsByYear W20653513712022 @default.
• W2065351371 countsByYear W20653513712023 @default.
• W2065351371 crossrefType "journal-article" @default.
• W2065351371 hasAuthorship W2065351371A5001973760 @default.
• W2065351371 hasAuthorship W2065351371A5011637777 @default.
• W2065351371 hasAuthorship W2065351371A5023307227 @default.
• W2065351371 hasAuthorship W2065351371A5032408859 @default.
• W2065351371 hasAuthorship W2065351371A5039325507 @default.
• W2065351371 hasAuthorship W2065351371A5047504790 @default.
• W2065351371 hasAuthorship W2065351371A5048511516 @default.
• W2065351371 hasAuthorship W2065351371A5054998515 @default.
• W2065351371 hasAuthorship W2065351371A5058177669 @default.
• W2065351371 hasAuthorship W2065351371A5061178178 @default.
• W2065351371 hasAuthorship W2065351371A5075150288 @default.
• W2065351371 hasConcept C104317684 @default.
• W2065351371 hasConcept C123298856 @default.
• W2065351371 hasConcept C13373296 @default.
• W2065351371 hasConcept C153911025 @default.
• W2065351371 hasConcept C164027704 @default.
• W2065351371 hasConcept C17991360 @default.
• W2065351371 hasConcept C183978625 @default.
• W2065351371 hasConcept C184235292 @default.
• W2065351371 hasConcept C185592680 @default.
• W2065351371 hasConcept C203014093 @default.
• W2065351371 hasConcept C2776415932 @default.
• W2065351371 hasConcept C2776914184 @default.
• W2065351371 hasConcept C2777730290 @default.
• W2065351371 hasConcept C2778690821 @default.
• W2065351371 hasConcept C51551487 @default.
• W2065351371 hasConcept C54355233 @default.
• W2065351371 hasConcept C55493867 @default.
• W2065351371 hasConcept C57074206 @default.
• W2065351371 hasConcept C62478195 @default.
• W2065351371 hasConcept C81885089 @default.
• W2065351371 hasConcept C86339819 @default.
• W2065351371 hasConcept C86803240 @default.
• W2065351371 hasConcept C8891405 @default.
• W2065351371 hasConceptScore W2065351371C104317684 @default.
• W2065351371 hasConceptScore W2065351371C123298856 @default.
• W2065351371 hasConceptScore W2065351371C13373296 @default.
• W2065351371 hasConceptScore W2065351371C153911025 @default.
• W2065351371 hasConceptScore W2065351371C164027704 @default.
• W2065351371 hasConceptScore W2065351371C17991360 @default.
• W2065351371 hasConceptScore W2065351371C183978625 @default.

• next