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- W2065352013 abstract "Introduction: Reperfusion injury is initiated by binding of certain IgM natural antibodies to neo-antigens exposed in ischemic tissue with subsequent activation of complement and other cytolytic pathways. Peptides that mimic the site of IgM binding to these antigens prevent IgM binding and prevent reperfusion injury when given intravenously to ischemic mice before reperfusion occurs. We now wish to determine whether this pathogenic natural IgM antibody-ischemia neo-antigen biology is restricted to mice or whether it is more general. We have therefore tested the ability of the peptide mimics to prevent reperfusion injury in a dissimilar species, the rat. Methods: Sprague-Dawley rats were subjected to 40 minutes of mesenteric ischemia followed by 180 minutes of reperfusion. The 12-mer peptide mimic was administered i.v. shortly prior to reperfusion at 300 ug/mL, estimated from the effective dose in the mouse. Gut injury was quantified using a scoring system based on the H+E section. 125-I labeled albumin was used to assess local injury as gut permeability and remote injury as lung permeability. Results: All injured rats showed gross bowel hemorrhage and edema, but bowel from peptide treated animals appeared much less edematous and hemorrhagic. Microscopic analysis of microvilli showed a significantly reduced injury score in peptide treated animals, although injury had not been completely prevented. Permeability data indicated a significant reduction in local and remote injury in peptide treated animals. Conclusions: The data demonstrates attenuation of rat gut microvillus injury, of gut edema, and of remote injury following mesenteric ischemia-reperfusion due to administration of an i.v. peptide mimic of a murine ischemia neo-antigen prior to reperfusion, thus indicating that a second species utilizes the same ischemia neo-antigen and corresponding natural antibody specificity to amplify reperfusion injury to the point of necrosis. This implies that this mechanism of inflammation is potentially applicable to higher species." @default.
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- W2065352013 date "2006-02-01" @default.
- W2065352013 modified "2023-10-14" @default.
- W2065352013 title "The mechanism of immune mediated ischemia-reperfusion injury is conserved between different animal species" @default.
- W2065352013 doi "https://doi.org/10.1016/j.jss.2005.11.453" @default.
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