FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065355613> ?p ?o ?g. }

• W2065355613 endingPage "446" @default.
• W2065355613 startingPage "432" @default.
• W2065355613 abstract "The Multicenter Study of Hydroxyurea in Sickle Cell Anemia is a randomized double-blind placebo-controlled trial to test whether hydroxyurea can reduce the rate of painful crises in adult patients who have at least three painful crises per year. The sample size of 299 patients yields at least 90% power to detect a 50% or greater reduction in crisis rate. Dosage starts at 15 mg/kg/day and is titrated to the patient's maximum tolerated dose up to 35 mg/kg/day. Placebo dosage is titrated in similar fashion to maintain blinding. Attempts are made to ascertain medical contacts for at least 2 years after study entry. The Core Laboratory, Treatment Distribution Center, and Data Coordinating Center collaborate to provide standardized monitoring for toxicity and dose adjustments. The Core Laboratory also reduces the possibility of inadvertent unmasking of treatment assignment during review of hematologic data in clinical centers. An independent Crisis Review Committee classifies clinical events to assure that outcome evaluations are standardized and unbiased by knowledge of treatment assignments. The Data and Safety Monitoring Board assures scientific integrity of the study, as well as the safety and ethical treatment of study patients. We expect the study to determine whether or not treatment with hydroxyurea can offer significant clinical benefit to patients with the most common hereditary disorder among African-Americans in the United States." @default.
• W2065355613 created "2016-06-24" @default.
• W2065355613 creator A5009862383 @default.
• W2065355613 creator A5018004404 @default.
• W2065355613 creator A5040544350 @default.
• W2065355613 creator A5045314404 @default.
• W2065355613 creator A5074418085 @default.
• W2065355613 creator A5082099289 @default.
• W2065355613 creator A5083307954 @default.
• W2065355613 creator A5086275373 @default.
• W2065355613 date "1995-12-01" @default.
• W2065355613 modified "2023-09-23" @default.
• W2065355613 title "Design of the multicenter study of hydroxyurea in sickle cell anemia" @default.
• W2065355613 cites W1513908576 @default.
• W2065355613 cites W1547032457 @default.
• W2065355613 cites W1565480413 @default.
• W2065355613 cites W1571615080 @default.
• W2065355613 cites W1965205173 @default.
• W2065355613 cites W1983733924 @default.
• W2065355613 cites W1992542423 @default.
• W2065355613 cites W1997412668 @default.
• W2065355613 cites W2004154642 @default.
• W2065355613 cites W2005752061 @default.
• W2065355613 cites W2010120116 @default.
• W2065355613 cites W2015488169 @default.
• W2065355613 cites W2022529274 @default.
• W2065355613 cites W2029724069 @default.
• W2065355613 cites W2035482751 @default.
• W2065355613 cites W2039678166 @default.
• W2065355613 cites W2043130582 @default.
• W2065355613 cites W2049129790 @default.
• W2065355613 cites W2066521171 @default.
• W2065355613 cites W2070849858 @default.
• W2065355613 cites W2086608011 @default.
• W2065355613 cites W2115244076 @default.
• W2065355613 cites W2276793530 @default.
• W2065355613 cites W2313541759 @default.
• W2065355613 cites W2322074970 @default.
• W2065355613 cites W2338369943 @default.
• W2065355613 cites W2404368999 @default.
• W2065355613 cites W2463162634 @default.
• W2065355613 cites W267386141 @default.
• W2065355613 cites W4231150319 @default.
• W2065355613 cites W4233026157 @default.
• W2065355613 cites W4249129014 @default.
• W2065355613 cites W4250610957 @default.
• W2065355613 cites W6223393 @default.
• W2065355613 cites W82508867 @default.
• W2065355613 cites W91104177 @default.
• W2065355613 doi "https://doi.org/10.1016/s0197-2456(95)00098-4" @default.
• W2065355613 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8925656" @default.
• W2065355613 hasPublicationYear "1995" @default.
• W2065355613 type Work @default.
• W2065355613 sameAs 2065355613 @default.
• W2065355613 citedByCount "130" @default.
• W2065355613 countsByYear W20653556132012 @default.
• W2065355613 countsByYear W20653556132013 @default.
• W2065355613 countsByYear W20653556132014 @default.
• W2065355613 countsByYear W20653556132015 @default.
• W2065355613 countsByYear W20653556132016 @default.
• W2065355613 countsByYear W20653556132017 @default.
• W2065355613 countsByYear W20653556132019 @default.
• W2065355613 countsByYear W20653556132020 @default.
• W2065355613 countsByYear W20653556132021 @default.
• W2065355613 countsByYear W20653556132022 @default.
• W2065355613 crossrefType "journal-article" @default.
• W2065355613 hasAuthorship W2065355613A5009862383 @default.
• W2065355613 hasAuthorship W2065355613A5018004404 @default.
• W2065355613 hasAuthorship W2065355613A5040544350 @default.
• W2065355613 hasAuthorship W2065355613A5045314404 @default.
• W2065355613 hasAuthorship W2065355613A5074418085 @default.
• W2065355613 hasAuthorship W2065355613A5082099289 @default.
• W2065355613 hasAuthorship W2065355613A5083307954 @default.
• W2065355613 hasAuthorship W2065355613A5086275373 @default.
• W2065355613 hasBestOaLocation W20653556131 @default.
• W2065355613 hasConcept C105795698 @default.
• W2065355613 hasConcept C126322002 @default.
• W2065355613 hasConcept C129848803 @default.
• W2065355613 hasConcept C141071460 @default.
• W2065355613 hasConcept C142724271 @default.
• W2065355613 hasConcept C168563851 @default.
• W2065355613 hasConcept C187212893 @default.
• W2065355613 hasConcept C194828623 @default.
• W2065355613 hasConcept C204787440 @default.
• W2065355613 hasConcept C27081682 @default.
• W2065355613 hasConcept C2771230 @default.
• W2065355613 hasConcept C2775965419 @default.
• W2065355613 hasConcept C2777106319 @default.
• W2065355613 hasConcept C2778248108 @default.
• W2065355613 hasConcept C2778620579 @default.
• W2065355613 hasConcept C2779134260 @default.
• W2065355613 hasConcept C2992435398 @default.
• W2065355613 hasConcept C33923547 @default.
• W2065355613 hasConcept C535046627 @default.
• W2065355613 hasConcept C71924100 @default.
• W2065355613 hasConceptScore W2065355613C105795698 @default.
• W2065355613 hasConceptScore W2065355613C126322002 @default.
• W2065355613 hasConceptScore W2065355613C129848803 @default.

• next