FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065390758> ?p ?o ?g. }

• W2065390758 endingPage "1525" @default.
• W2065390758 startingPage "1520" @default.
• W2065390758 abstract "Amyloid β protein (Aβ)-induced free radical-mediated neurotoxicity is known as a leading hypothesis for a cause of Alzheimer's disease. Aβ increased free radical production and lipid peroxidation in PC12 nerve cells, resulting in apoptosis and cell death. The protective effect of naringenin, a major flavanone constituent isolated from Citrus junos, against Aβ-induced neurotoxicity was investigated using PC12 cells. Pretreatment with isolated naringenin and vitamin C prevented the generation of the Aβ-induced reactive oxygen species. Naringenin resulted in the decrease of Aβ toxicity in a manner of concentration dependence, which was assessed by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. However, treatment with these antioxidants inhibited the Aβ-induced neurotoxic effect. The antiamnestic activity of naringenin in vivo was also evaluated using ICR mice with amnesia induced by scopolamine (1 mg/kg body weight). Naringenin, when administered to ICR mice at 4.5 mg/kg body weight, significantly ameliorated scopolamine-induced amnesia as measured in the passive avoidance test. Therefore, these results indicate that micromolecular Aβ-induced in vitro oxidative cell stress is reduced by naringenin and naringenin may be a useful chemopreventive agent against a neurodegenerative disease such as Alzheimer's disease. Keywords: Naringenin; oxidative stress; Alzheimer's disease; antiamnestic agent" @default.
• W2065390758 created "2016-06-24" @default.
• W2065390758 creator A5011356826 @default.
• W2065390758 creator A5025853867 @default.
• W2065390758 creator A5035803715 @default.
• W2065390758 creator A5043749761 @default.
• W2065390758 creator A5068015925 @default.
• W2065390758 creator A5082099749 @default.
• W2065390758 date "2004-02-27" @default.
• W2065390758 modified "2023-10-18" @default.
• W2065390758 title "Effect of Antioxidant Flavanone, Naringenin, from <i>Citrus junos </i>on Neuroprotection" @default.
• W2065390758 cites W1568953429 @default.
• W2065390758 cites W1986783906 @default.
• W2065390758 cites W1987469323 @default.
• W2065390758 cites W2016293448 @default.
• W2065390758 cites W2018769094 @default.
• W2065390758 cites W2029552699 @default.
• W2065390758 cites W2032350023 @default.
• W2065390758 cites W2033592766 @default.
• W2065390758 cites W2041601285 @default.
• W2065390758 cites W2076695795 @default.
• W2065390758 cites W2087822620 @default.
• W2065390758 cites W2090313884 @default.
• W2065390758 cites W2092845324 @default.
• W2065390758 cites W2118206405 @default.
• W2065390758 cites W2129902275 @default.
• W2065390758 cites W2138229899 @default.
• W2065390758 cites W2156257098 @default.
• W2065390758 cites W2158748165 @default.
• W2065390758 cites W2315071131 @default.
• W2065390758 doi "https://doi.org/10.1021/jf035079g" @default.
• W2065390758 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15030205" @default.
• W2065390758 hasPublicationYear "2004" @default.
• W2065390758 type Work @default.
• W2065390758 sameAs 2065390758 @default.
• W2065390758 citedByCount "156" @default.
• W2065390758 countsByYear W20653907582012 @default.
• W2065390758 countsByYear W20653907582013 @default.
• W2065390758 countsByYear W20653907582014 @default.
• W2065390758 countsByYear W20653907582015 @default.
• W2065390758 countsByYear W20653907582016 @default.
• W2065390758 countsByYear W20653907582017 @default.
• W2065390758 countsByYear W20653907582018 @default.
• W2065390758 countsByYear W20653907582019 @default.
• W2065390758 countsByYear W20653907582020 @default.
• W2065390758 countsByYear W20653907582021 @default.
• W2065390758 countsByYear W20653907582022 @default.
• W2065390758 countsByYear W20653907582023 @default.
• W2065390758 crossrefType "journal-article" @default.
• W2065390758 hasAuthorship W2065390758A5011356826 @default.
• W2065390758 hasAuthorship W2065390758A5025853867 @default.
• W2065390758 hasAuthorship W2065390758A5035803715 @default.
• W2065390758 hasAuthorship W2065390758A5043749761 @default.
• W2065390758 hasAuthorship W2065390758A5068015925 @default.
• W2065390758 hasAuthorship W2065390758A5082099749 @default.
• W2065390758 hasConcept C178790620 @default.
• W2065390758 hasConcept C185592680 @default.
• W2065390758 hasConcept C25498285 @default.
• W2065390758 hasConcept C2776151105 @default.
• W2065390758 hasConcept C2776848411 @default.
• W2065390758 hasConcept C2777481717 @default.
• W2065390758 hasConcept C2778004101 @default.
• W2065390758 hasConcept C2779054382 @default.
• W2065390758 hasConcept C2779491297 @default.
• W2065390758 hasConcept C2780829032 @default.
• W2065390758 hasConcept C29730261 @default.
• W2065390758 hasConcept C48349386 @default.
• W2065390758 hasConcept C55493867 @default.
• W2065390758 hasConcept C86803240 @default.
• W2065390758 hasConcept C98274493 @default.
• W2065390758 hasConceptScore W2065390758C178790620 @default.
• W2065390758 hasConceptScore W2065390758C185592680 @default.
• W2065390758 hasConceptScore W2065390758C25498285 @default.
• W2065390758 hasConceptScore W2065390758C2776151105 @default.
• W2065390758 hasConceptScore W2065390758C2776848411 @default.
• W2065390758 hasConceptScore W2065390758C2777481717 @default.
• W2065390758 hasConceptScore W2065390758C2778004101 @default.
• W2065390758 hasConceptScore W2065390758C2779054382 @default.
• W2065390758 hasConceptScore W2065390758C2779491297 @default.
• W2065390758 hasConceptScore W2065390758C2780829032 @default.
• W2065390758 hasConceptScore W2065390758C29730261 @default.
• W2065390758 hasConceptScore W2065390758C48349386 @default.
• W2065390758 hasConceptScore W2065390758C55493867 @default.
• W2065390758 hasConceptScore W2065390758C86803240 @default.
• W2065390758 hasConceptScore W2065390758C98274493 @default.
• W2065390758 hasIssue "6" @default.
• W2065390758 hasLocation W20653907581 @default.
• W2065390758 hasLocation W20653907582 @default.
• W2065390758 hasOpenAccess W2065390758 @default.
• W2065390758 hasPrimaryLocation W20653907581 @default.
• W2065390758 hasRelatedWork W1470000624 @default.
• W2065390758 hasRelatedWork W2006516560 @default.
• W2065390758 hasRelatedWork W2048418896 @default.
• W2065390758 hasRelatedWork W2061140793 @default.
• W2065390758 hasRelatedWork W2387770678 @default.
• W2065390758 hasRelatedWork W2979806364 @default.
• W2065390758 hasRelatedWork W3023991191 @default.
• W2065390758 hasRelatedWork W3087872028 @default.

• next