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- W2065391775 endingPage "36" @default.
- W2065391775 startingPage "27" @default.
- W2065391775 abstract "The role of the immune system is to recognize pathogens, tumor cells or dead cells and to react with a very specific and localized response. By taking advantage of a highly sophisticated system of chemokines and chemokine receptors, leukocytes such as neutrophils, macrophages, and T-lymphocytes are targeted to the precise location of inflammation. While this is a beneficial process for acute infection and inflammation, recruitment of immune cells to sites of chronic inflammation can be detrimental. It is becoming clear that these inflammatory cells play a significant role in the initiation and progression of metabolic disorders such as atherosclerosis and insulin resistance by infiltrating the artery wall and adipose tissue (AT), respectively. Data from human studies indicate that elevated plasma levels of chemokines are correlated with these metabolic diseases. Recruitment of macrophages to the artery wall is well known to be one of the first steps in early atherosclerotic lesion formation. Likewise, recruitment of macrophages to AT is thought to contribute to insulin resistance associated with obesity. Based on this knowledge, much recent work in these areas has focused on the role of chemokines in attracting immune cells (monocytes/macrophages in particular) to these 2 sites. Thus, understanding the potential for chemokines to contribute to metabolic disease can help direct studies of chemokines as therapeutic targets. In this article, we will review current literature regarding the role of chemokines in atherosclerosis and obesity-related insulin resistance. We will focus on novel work showing that chemokine secretion from endothelial cells, platelets, and adipocytes can contribute to immune cell recruitment, with a diagram showing the time course of chemokine expression and leukocyte recruitment to AT. We will also highlight a few of the less-commonly known chemokine–chemokine receptor pairs. Finally, we will discuss the potential for chemokines as therapeutic targets for treatment of atherosclerosis and insulin resistance." @default.
- W2065391775 created "2016-06-24" @default.
- W2065391775 creator A5042917771 @default.
- W2065391775 creator A5082971980 @default.
- W2065391775 date "2010-01-01" @default.
- W2065391775 modified "2023-10-18" @default.
- W2065391775 title "The role of chemokines in recruitment of immune cells to the artery wall and adipose tissue" @default.
- W2065391775 cites W1516434930 @default.
- W2065391775 cites W1553712313 @default.
- W2065391775 cites W1561516029 @default.
- W2065391775 cites W1965158621 @default.
- W2065391775 cites W1966241241 @default.
- W2065391775 cites W1967409248 @default.
- W2065391775 cites W1967517822 @default.
- W2065391775 cites W1968248944 @default.
- W2065391775 cites W1977167754 @default.
- W2065391775 cites W1986610158 @default.
- W2065391775 cites W1988362062 @default.
- W2065391775 cites W1989478136 @default.
- W2065391775 cites W1994851844 @default.
- W2065391775 cites W1996726960 @default.
- W2065391775 cites W1997284331 @default.
- W2065391775 cites W2002638829 @default.
- W2065391775 cites W2010957046 @default.
- W2065391775 cites W2011009843 @default.
- W2065391775 cites W2011650513 @default.
- W2065391775 cites W2014867833 @default.
- W2065391775 cites W2015681606 @default.
- W2065391775 cites W2020245957 @default.
- W2065391775 cites W2021127773 @default.
- W2065391775 cites W2022490412 @default.
- W2065391775 cites W2030051619 @default.
- W2065391775 cites W2031397753 @default.
- W2065391775 cites W2032811951 @default.
- W2065391775 cites W2033442974 @default.
- W2065391775 cites W2034541077 @default.
- W2065391775 cites W2037493697 @default.
- W2065391775 cites W2052544509 @default.
- W2065391775 cites W2054391979 @default.
- W2065391775 cites W2056568186 @default.
- W2065391775 cites W2056897769 @default.
- W2065391775 cites W2060235331 @default.
- W2065391775 cites W2063703263 @default.
- W2065391775 cites W2065432525 @default.
- W2065391775 cites W2069901353 @default.
- W2065391775 cites W2070725804 @default.
- W2065391775 cites W2072190804 @default.
- W2065391775 cites W2072633424 @default.
- W2065391775 cites W2073933067 @default.
- W2065391775 cites W2076817774 @default.
- W2065391775 cites W2077792952 @default.
- W2065391775 cites W2079039691 @default.
- W2065391775 cites W2081859430 @default.
- W2065391775 cites W2084243977 @default.
- W2065391775 cites W2085869287 @default.
- W2065391775 cites W2092632463 @default.
- W2065391775 cites W2094862143 @default.
- W2065391775 cites W2098101490 @default.
- W2065391775 cites W2098307218 @default.
- W2065391775 cites W2098651296 @default.
- W2065391775 cites W2103018133 @default.
- W2065391775 cites W2103878792 @default.
- W2065391775 cites W2104899502 @default.
- W2065391775 cites W2105212193 @default.
- W2065391775 cites W2105844711 @default.
- W2065391775 cites W2106246085 @default.
- W2065391775 cites W2110630581 @default.
- W2065391775 cites W2111842746 @default.
- W2065391775 cites W2112004869 @default.
- W2065391775 cites W2113903712 @default.
- W2065391775 cites W2115781901 @default.
- W2065391775 cites W2121176432 @default.
- W2065391775 cites W2122035828 @default.
- W2065391775 cites W2124263104 @default.
- W2065391775 cites W2124989653 @default.
- W2065391775 cites W2125469512 @default.
- W2065391775 cites W2128099923 @default.
- W2065391775 cites W2128429838 @default.
- W2065391775 cites W2128471953 @default.
- W2065391775 cites W2128568899 @default.
- W2065391775 cites W2133311030 @default.
- W2065391775 cites W2133647080 @default.
- W2065391775 cites W2136325680 @default.
- W2065391775 cites W2136376178 @default.
- W2065391775 cites W2137636472 @default.
- W2065391775 cites W2138422542 @default.
- W2065391775 cites W2139959600 @default.
- W2065391775 cites W2141554996 @default.
- W2065391775 cites W2142342780 @default.
- W2065391775 cites W2144032315 @default.
- W2065391775 cites W2145690342 @default.
- W2065391775 cites W2149785827 @default.
- W2065391775 cites W2150252938 @default.
- W2065391775 cites W2151597066 @default.
- W2065391775 cites W2160915024 @default.
- W2065391775 cites W2162107224 @default.
- W2065391775 cites W2165202791 @default.
- W2065391775 cites W2165334726 @default.