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- W2065392671 abstract "Exploration of the dynamic aspects of preeclampsia. 216 patients with (H)ELLP-syndrome (n = 54), severe preeclampsia (n = 80),or pregnancy-induced-hypertension related fetal growth restriction (n = 82) and gestational age between 24 and 34 completed weeks were randomized for temporizing management with plasma volume expansion (n = 111; 250 ml HydroxyEthylStarch 6% twice daily in 4 hours) or without (n = 105). Primary endpoints of the study were a neurological optimality score of the neonate at term age (Prechtl) and perinatal mortality. Composite maternal complications (CMC) were defined as major maternal morbidity (abruptio placentae, pulmonary edema, liver hematoma, sepsis, pulmonary embolism), newly acquired, persistent or recurrent HELLP and eclampsia after inclusion. Onset of morbidity after admission was categorized in three-day periods. Median prolongation until delivery was 7.4 (0.2-35) days in the treatment group and 10.5 (0.2-44) days (P = .054) in the control group, and the incidence of CMC 32% and 35% (P = .6). Primary outcome criteria were similar. The incidence of CMC in the total group was 8 % (range 4-11) / 3 days during the first 14 days after admission and thereafter 3% (range 0-6) / 3 days. Postpartum incidence of CMC was 8%. The incidence of CMC was constant during the first two weeks afer admission and diminished thereafter. Treatment allocation had no influence." @default.
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- W2065392671 date "2004-12-01" @default.
- W2065392671 modified "2023-09-28" @default.
- W2065392671 title "Dynamic aspects of preeclampsia" @default.
- W2065392671 doi "https://doi.org/10.1016/j.ajog.2004.09.123" @default.
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