FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065395239> ?p ?o ?g. }

• W2065395239 endingPage "1253" @default.
• W2065395239 startingPage "1247" @default.
• W2065395239 abstract "Fasting serum total immunoreactive insulin (IRI), true insulin, and true proinsulin (PI) were measured in 169 Pima Indians. The relationship of these variables to glucose tolerance, obesity, and parental diabetes was studied. Seventy-seven subjects had normal glucose tolerance, 46 had impaired glucose tolerance (IGT), and 46 had noninsulin-dependent diabetes mellitus (NIDDM) by WHO criteria. In subjects with normal glucose tolerance, the geometric mean ratio of PI to IRI (PI/IRI) was 10.8% (arithmetic mean, 12.5%), similar to that reported in other ethnic groups with lower prevalence rates of NIDDM. Parental diabetes had no effect on PI/IRI. Obese persons (body mass index, greater than or equal to 27 kg/m2) with normal glucose tolerance had PI/IRI of 9.3% compared with 16.3% for the nonobese (P less than 0.001), and PI/IRI was negatively correlated with body mass index (r = -0.34; P = 0.002). Proinsulin was disproportionately elevated in NIDDM (geometric mean PI/IRI, 19.9%; arithmetic mean, 23.6%), and the degree of elevation was related to the severity of hyperglycemia, but not the duration of diabetes. Subjects with IGT were more obese and had higher fasting plasma glucose (5.7 vs. 5.2 mmol/L; P = 0.025), true insulin (250 vs. 125 pmol/L; P less than 0.001), and PI concentrations (26 vs. 15 pmol/L; P less than 0.001) than those with normal glucose tolerance but similar mean PI/IRI (9.4 vs. 10.8%; P = 0.4). These findings indicate that Pima Indians with NIDDM have a disproportionate elevation of PI consistent with the hypothesis that beta-cell dysfunction associated with hyperglycemia leads to the release of proinsulin-rich immature granules." @default.
• W2065395239 created "2016-06-24" @default.
• W2065395239 creator A5027176743 @default.
• W2065395239 creator A5050165878 @default.
• W2065395239 creator A5053691497 @default.
• W2065395239 creator A5053926256 @default.
• W2065395239 creator A5072056585 @default.
• W2065395239 creator A5081025519 @default.
• W2065395239 creator A5081397975 @default.
• W2065395239 creator A5084019702 @default.
• W2065395239 creator A5088560891 @default.
• W2065395239 date "1990-05-01" @default.
• W2065395239 modified "2023-09-25" @default.
• W2065395239 title "Disproportionately Elevated Proinsulin in Pima Indians with Noninsulin-Dependent Diabetes Mellitus*" @default.
• W2065395239 cites W1950036743 @default.
• W2065395239 cites W1966480643 @default.
• W2065395239 cites W1974554536 @default.
• W2065395239 cites W1978027514 @default.
• W2065395239 cites W2001666927 @default.
• W2065395239 cites W2004551606 @default.
• W2065395239 cites W2011111542 @default.
• W2065395239 cites W2020522449 @default.
• W2065395239 cites W2020807418 @default.
• W2065395239 cites W2026316039 @default.
• W2065395239 cites W2028749119 @default.
• W2065395239 cites W2030702380 @default.
• W2065395239 cites W2033392651 @default.
• W2065395239 cites W2043209055 @default.
• W2065395239 cites W2043244814 @default.
• W2065395239 cites W2060501437 @default.
• W2065395239 cites W2068569405 @default.
• W2065395239 cites W2070249820 @default.
• W2065395239 cites W2078600657 @default.
• W2065395239 cites W2079248356 @default.
• W2065395239 cites W2082697452 @default.
• W2065395239 cites W2087080454 @default.
• W2065395239 cites W2108867880 @default.
• W2065395239 cites W2128336854 @default.
• W2065395239 cites W2131796548 @default.
• W2065395239 cites W2132705610 @default.
• W2065395239 cites W2143554720 @default.
• W2065395239 cites W2154225169 @default.
• W2065395239 cites W2170293889 @default.
• W2065395239 cites W2186184337 @default.
• W2065395239 cites W627977585 @default.
• W2065395239 cites W2468622561 @default.
• W2065395239 doi "https://doi.org/10.1210/jcem-70-5-1247" @default.
• W2065395239 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2186054" @default.
• W2065395239 hasPublicationYear "1990" @default.
• W2065395239 type Work @default.
• W2065395239 sameAs 2065395239 @default.
• W2065395239 citedByCount "164" @default.
• W2065395239 countsByYear W20653952392012 @default.
• W2065395239 countsByYear W20653952392013 @default.
• W2065395239 countsByYear W20653952392014 @default.
• W2065395239 countsByYear W20653952392015 @default.
• W2065395239 countsByYear W20653952392016 @default.
• W2065395239 countsByYear W20653952392017 @default.
• W2065395239 countsByYear W20653952392018 @default.
• W2065395239 countsByYear W20653952392019 @default.
• W2065395239 countsByYear W20653952392020 @default.
• W2065395239 countsByYear W20653952392021 @default.
• W2065395239 countsByYear W20653952392022 @default.
• W2065395239 crossrefType "journal-article" @default.
• W2065395239 hasAuthorship W2065395239A5027176743 @default.
• W2065395239 hasAuthorship W2065395239A5050165878 @default.
• W2065395239 hasAuthorship W2065395239A5053691497 @default.
• W2065395239 hasAuthorship W2065395239A5053926256 @default.
• W2065395239 hasAuthorship W2065395239A5072056585 @default.
• W2065395239 hasAuthorship W2065395239A5081025519 @default.
• W2065395239 hasAuthorship W2065395239A5081397975 @default.
• W2065395239 hasAuthorship W2065395239A5084019702 @default.
• W2065395239 hasAuthorship W2065395239A5088560891 @default.
• W2065395239 hasConcept C126322002 @default.
• W2065395239 hasConcept C134018914 @default.
• W2065395239 hasConcept C2777185836 @default.
• W2065395239 hasConcept C2777391703 @default.
• W2065395239 hasConcept C2779306644 @default.
• W2065395239 hasConcept C2780221984 @default.
• W2065395239 hasConcept C2780609358 @default.
• W2065395239 hasConcept C511355011 @default.
• W2065395239 hasConcept C555293320 @default.
• W2065395239 hasConcept C71924100 @default.
• W2065395239 hasConcept C90061646 @default.
• W2065395239 hasConceptScore W2065395239C126322002 @default.
• W2065395239 hasConceptScore W2065395239C134018914 @default.
• W2065395239 hasConceptScore W2065395239C2777185836 @default.
• W2065395239 hasConceptScore W2065395239C2777391703 @default.
• W2065395239 hasConceptScore W2065395239C2779306644 @default.
• W2065395239 hasConceptScore W2065395239C2780221984 @default.
• W2065395239 hasConceptScore W2065395239C2780609358 @default.
• W2065395239 hasConceptScore W2065395239C511355011 @default.
• W2065395239 hasConceptScore W2065395239C555293320 @default.
• W2065395239 hasConceptScore W2065395239C71924100 @default.
• W2065395239 hasConceptScore W2065395239C90061646 @default.
• W2065395239 hasIssue "5" @default.
• W2065395239 hasLocation W20653952391 @default.
• W2065395239 hasLocation W20653952392 @default.

• next