FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065399019> ?p ?o ?g. }

• W2065399019 endingPage "54" @default.
• W2065399019 startingPage "48" @default.
• W2065399019 abstract "This study was designed to investigate the possible effect of sitagliptin on renal damage induced by renal ischemia reperfusion (I/R) in diabetic rats. T2DM in rats was induced by the administration of nicotinamide (230 mg/kg, i.p.), 15 min prior to a single dose of streptozotocin (65 mg/kg, i.v.). In vivo renal I/R was performed in both T2DM and normal rats. Each protocol comprised ischemia for 30 min followed by reperfusion for 24h and a treatment period of 14 days before induction of ischemia. Sitagliptin treated diabetic rats that underwent renal I/R demonstrated significant decrease in the serum concentrations of aspartate aminotransferase (p < 0.01), urea nitrogen (p < 0.01) and creatinine (p < 0.001) compared to renal I/R in diabetic rats. Lipid peroxidation, xanthine oxidase activity, myeloperoxidase activity and nitric oxide level in renal tissue were significantly (p < 0.05, p < 0.001, p < 0.01, p < 0.05 respectively) decreased after renal I/R in sitagliptin treated rats compared to diabetic rats. Antioxidant enzymes like glutathione (p < 0.05), glutathione peroxidase (p < 0.001), superoxide dismutase (p < 0.05) and catalase (p < 0.001) were significantly increased after renal I/R in sitagliptin treated diabetic rats compared to non treated diabetic rats. The typical DNA laddering was observed when renal I/R performed in diabetic rats, which indicates cell apoptosis. Sitagliptin treated rats demonstrated a decrease in DNA fragmentation and apoptosis. Furthermore, renal histopathology preserved in sitagliptin treated rats verified protection against renal I/R in diabetes. The results of present investigation established sitagliptin treatment attenuated renal damage induced by renal I/R in diabetic rats." @default.
• W2065399019 created "2016-06-24" @default.
• W2065399019 creator A5045192121 @default.
• W2065399019 creator A5048444201 @default.
• W2065399019 creator A5059598298 @default.
• W2065399019 creator A5073967835 @default.
• W2065399019 date "2011-01-01" @default.
• W2065399019 modified "2023-09-26" @default.
• W2065399019 title "Sitagliptin protects renal ischemia reperfusion induced renal damage in diabetes" @default.
• W2065399019 cites W1567614586 @default.
• W2065399019 cites W1750690213 @default.
• W2065399019 cites W1899938340 @default.
• W2065399019 cites W191793640 @default.
• W2065399019 cites W1968785372 @default.
• W2065399019 cites W1968939832 @default.
• W2065399019 cites W1984664578 @default.
• W2065399019 cites W1989059321 @default.
• W2065399019 cites W1993535066 @default.
• W2065399019 cites W1997358375 @default.
• W2065399019 cites W2001326822 @default.
• W2065399019 cites W2003110293 @default.
• W2065399019 cites W2005644048 @default.
• W2065399019 cites W2007681259 @default.
• W2065399019 cites W2012243962 @default.
• W2065399019 cites W2015380882 @default.
• W2065399019 cites W2023988302 @default.
• W2065399019 cites W2025419894 @default.
• W2065399019 cites W2026964236 @default.
• W2065399019 cites W2036884952 @default.
• W2065399019 cites W2048981028 @default.
• W2065399019 cites W2051804460 @default.
• W2065399019 cites W2065582045 @default.
• W2065399019 cites W2065836621 @default.
• W2065399019 cites W2066301620 @default.
• W2065399019 cites W2069132215 @default.
• W2065399019 cites W2084204140 @default.
• W2065399019 cites W2104818363 @default.
• W2065399019 cites W2134141467 @default.
• W2065399019 cites W2137137628 @default.
• W2065399019 cites W2160908214 @default.
• W2065399019 cites W2166344923 @default.
• W2065399019 cites W2324409724 @default.
• W2065399019 cites W3164850907 @default.
• W2065399019 cites W4232396514 @default.
• W2065399019 cites W4235235032 @default.
• W2065399019 cites W4237872556 @default.
• W2065399019 cites W4290995475 @default.
• W2065399019 doi "https://doi.org/10.1016/j.regpep.2010.08.007" @default.
• W2065399019 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20728477" @default.
• W2065399019 hasPublicationYear "2011" @default.
• W2065399019 type Work @default.
• W2065399019 sameAs 2065399019 @default.
• W2065399019 citedByCount "88" @default.
• W2065399019 countsByYear W20653990192012 @default.
• W2065399019 countsByYear W20653990192013 @default.
• W2065399019 countsByYear W20653990192014 @default.
• W2065399019 countsByYear W20653990192015 @default.
• W2065399019 countsByYear W20653990192016 @default.
• W2065399019 countsByYear W20653990192017 @default.
• W2065399019 countsByYear W20653990192018 @default.
• W2065399019 countsByYear W20653990192019 @default.
• W2065399019 countsByYear W20653990192020 @default.
• W2065399019 countsByYear W20653990192021 @default.
• W2065399019 countsByYear W20653990192022 @default.
• W2065399019 countsByYear W20653990192023 @default.
• W2065399019 crossrefType "journal-article" @default.
• W2065399019 hasAuthorship W2065399019A5045192121 @default.
• W2065399019 hasAuthorship W2065399019A5048444201 @default.
• W2065399019 hasAuthorship W2065399019A5059598298 @default.
• W2065399019 hasAuthorship W2065399019A5073967835 @default.
• W2065399019 hasConcept C126322002 @default.
• W2065399019 hasConcept C134018914 @default.
• W2065399019 hasConcept C181199279 @default.
• W2065399019 hasConcept C185592680 @default.
• W2065399019 hasConcept C2775838275 @default.
• W2065399019 hasConcept C2776151105 @default.
• W2065399019 hasConcept C2777180221 @default.
• W2065399019 hasConcept C2778102346 @default.
• W2065399019 hasConcept C2778760513 @default.
• W2065399019 hasConcept C2779280383 @default.
• W2065399019 hasConcept C2779284873 @default.
• W2065399019 hasConcept C2780091579 @default.
• W2065399019 hasConcept C2780114680 @default.
• W2065399019 hasConcept C2780721119 @default.
• W2065399019 hasConcept C541997718 @default.
• W2065399019 hasConcept C55493867 @default.
• W2065399019 hasConcept C555293320 @default.
• W2065399019 hasConcept C71924100 @default.
• W2065399019 hasConceptScore W2065399019C126322002 @default.
• W2065399019 hasConceptScore W2065399019C134018914 @default.
• W2065399019 hasConceptScore W2065399019C181199279 @default.
• W2065399019 hasConceptScore W2065399019C185592680 @default.
• W2065399019 hasConceptScore W2065399019C2775838275 @default.
• W2065399019 hasConceptScore W2065399019C2776151105 @default.
• W2065399019 hasConceptScore W2065399019C2777180221 @default.
• W2065399019 hasConceptScore W2065399019C2778102346 @default.
• W2065399019 hasConceptScore W2065399019C2778760513 @default.
• W2065399019 hasConceptScore W2065399019C2779280383 @default.

• next