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• W2065405586 abstract "Purpose: To investigate the morphological effects of acute overdistension in the structure of the extracellular matrix of the bladder wall in rats. — Materials and Methods: The bladders of a group of 6 male Wistar rats were transurethrally overdistended for 3 hours. Another identical group (the control group) was only submitted to a sham operation. Specimens from the bladder dome were analyzed with light microscopy (LM), transmission electron microscopy (TEM) and scanning electron microscopy (SEM). — Results: LM — The control group bladders had a 4 to 5 layer urothelium, a lamina propria, and a smooth muscle layer with longitudinal and transversal fibers. The overdistended bladders presented an intense interstitial infiltrate in the lamina propria, and a less intense infiltrate among the smooth muscle fibers. TEM — The cells of the overdistended bladders had a significant amount of vacuoles, unlike the control bladders, where such vacuoles were scarce or absent. SEM — A delicate three-dimensional mesh of collagen fibrils was observed in the lamina propria of the bladder walls from the control group. Whilst for the control group this mesh consisted of distinct geometric structures, with mostly circular cellular spaces surrounded by the fibrils, the overdistended group showed evidence of distortion of the mesh, with flattened and elongated cellular spaces. — Conclusions: Acute bladder overdistension induces structural modifications, altering the arrangement and interaction of collagen fibrils, as well as incipient tissue damage as edema in the lamina propria and smooth muscle layers." @default.
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• W2065405586 date "2004-02-01" @default.
• W2065405586 modified "2023-10-18" @default.
• W2065405586 title "Morphological analysis of the acute effects of overdistension on the extracellular matrix of the rat urinary bladder wall" @default.
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• W2065405586 doi "https://doi.org/10.1016/s0940-9602(04)80122-5" @default.
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