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- W2065407738 abstract "The possible involvement of purines in the non-adrenergic non-cholinergic (NANC) relaxation of rat duodenum was studied using an isometric-isovolumic preparation. Purines (adenosine, AMP, ADP, ATP) induced a concentration-dependent, tetrodotoxin (TTX)-insensitive, fall in both endoluminal pressure and isometric tension. The relaxation induced by adenosine and by 2-chloroadenosine was selectively antagonized by 8-phenyltheophylline (1, 10 nM, 0.5 μM) and the ATP-induced relaxation was opposed by α,β-methylene ATP (10 μM) and by reactive blue 2 (10 μM). Electrical field stimulation (EFS) caused TTX-sensitive inhibitory effects similar to those induced by ATP. None of the purinergic antagonists used were capable of affecting the EFS-induced relaxation. Our results indicate that both P1 and P2 purinoreceptors are present in muscle of the rat duodenum and are not involved in the NANC relaxation." @default.
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- W2065407738 date "1990-07-01" @default.
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- W2065407738 title "Evidence against purines being neurotransmitters of non-adrenergic, non-cholinergic nerves in rat duodenum" @default.
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- W2065407738 doi "https://doi.org/10.1016/0014-2999(90)90046-9" @default.
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