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- W2065419469 abstract "Highly active antiretroviral therapy (HAART) has significantly prolonged the lives of HIV-infected patients but low level chronic immune activation remains in some. Neurodegenerative diseases are often associated with immune activation which likely plays a role in their pathogenesis.1 Recently, increased alpha-synuclein deposition in the substantia nigra in aging HIV-infected patients has been identified,2 although there was no clear clinical correlate. These observations suggest that HIV and HAART may facilitate the development of neurodegeneration and accelerate the appearance of diseases such as Parkinson disease (PD) via mechanisms including inflammation, mitochondrial dysfunction, and interference with the ubiquitin proteasome pathway.1 Here we describe 3 patients with relatively young onset of parkinsonism in the context of HIV and HAART.### Case series.The patients were HIV-infected men aged between 44 and 55 years on HAART who were examined prior to the development of parkinsonism. None had been exposed to neuroleptic medications or recent amphetamine use. All developed initial unilateral upper extremity rest tremor, followed by rigidity, bradykinesia, and mild gait involvement with preserved postural stability. Importantly, cognitive, oculomotor, pyramidal, cerebellar, and autonomic features were absent. Only patient 3 responded well to levodopa; however, the dose …" @default.
- W2065419469 created "2016-06-24" @default.
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- W2065419469 date "2009-08-03" @default.
- W2065419469 modified "2023-10-14" @default.
- W2065419469 title "PARKINSONISM IN HIV-INFECTED PATIENTS ON HIGHLY ACTIVE ANTIRETROVIRAL THERAPY" @default.
- W2065419469 doi "https://doi.org/10.1212/wnl.0b013e3181b04b0d" @default.
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