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- W2065431218 abstract "Two isoforms of a bovine‐brain‐derived 12‐kDa protein (designated p12 a and p12 b ) whose N‐termini have a high amino acid sequence similarity with the glycosylation‐inhibiting factor (GIF) and macrophage migration‐inhibitory factor (MIF) were purified to homogeneity. The complete amino acid sequence of bovine p12 a (pI 9.5) was determined by Edman degradation of the intact molecule and overlapping fragments generated by proteolytic cleavage. The p12 a isoform has nine and ten conservative substitutions versus human GIF (hGIF) and human MIF (hMIF), respectively. Molecular filtration revealed that both isoforms of p12 exist as monomers in aqueous solution. Circular dichroism spectra indicate that both isoforms of p12 consist of 39±3%α helix, 23±3%β structure and 15±3%β turns. Although the N‐terminal parts of p12 a and p12 b have weak amino acid sequence similarity with that of glutathione S‐transferase (GST) neither isoform of p12 was bound to a GST‐affinity gel nor had GST activity. Despite a high amino acid sequence similarity with human MIF neither of the p12 isoforms inhibited migration of the mouse monocyte‐macrophage cells P338D 1 ." @default.
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- W2065431218 title "A Diversified Family of 12-kDa Proteins with a High Amino Acid Sequence Similarity to Macrophage Migration-Inhibitory Factor (MIF)" @default.
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- W2065431218 doi "https://doi.org/10.1111/j.1432-1033.1994.00417.x" @default.
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