Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065431406> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2065431406 endingPage "218" @default.
- W2065431406 startingPage "215" @default.
- W2065431406 abstract "In Brief Reduction of serum urate and phosphate levels has been observed in patients receiving leflunomide therapy, but the mechanism for such changes has not been evaluated. Thirty-eight patients with rheumatoid arthritis who began leflunomide were studied. Serum urate, creatinine, and phosphate, and 24-hour uric acid, creatinine, and phosphate were measured before, during, and in some instances after leflunomide treatment. Clearances of urate and creatinine, fractional excretion of urate, and tubular reabsorption of phosphate were calculated. Undissociated urinary uric acid was estimated with a nomogram. Twelve patients gave consent to withdraw leflunomide treatment of a 2-week period and underwent a third study. Decreases in serum urate and phosphate levels were observed, with parallel increases in clearances of urate and in fractional excretion of urate, and a reduction in tubular reabsorption of phosphate. Clearances of creatinine and undissociated urinary uric acid remained unchanged. Two weeks after withdrawing the drug, a partial return toward baseline values was observed, but residual changes were apparent. No case of clinical gout was observed. Leflunomide enhances urate and phosphate loss, an effect that partially persisted after 2-week withdrawal. The long-term effect of mild phosphate wasting warrants further investigation. The urate-lowering effect of leflunomide may be useful in monitoring compliance in leflunomide therapy. Leflunomide can cause both hypouricemia and hypophosphatemia." @default.
- W2065431406 created "2016-06-24" @default.
- W2065431406 creator A5004595376 @default.
- W2065431406 creator A5035309374 @default.
- W2065431406 date "2003-08-01" @default.
- W2065431406 modified "2023-10-18" @default.
- W2065431406 title "Influence of Leflunomide on Renal Handling of Urate and Phosphate in Patients with Rheumatoid Arthritis" @default.
- W2065431406 cites W2018113485 @default.
- W2065431406 cites W2051497395 @default.
- W2065431406 cites W2083284361 @default.
- W2065431406 cites W2104129745 @default.
- W2065431406 cites W2120574509 @default.
- W2065431406 cites W2129314512 @default.
- W2065431406 cites W2152348310 @default.
- W2065431406 cites W2154147815 @default.
- W2065431406 cites W2228301361 @default.
- W2065431406 cites W2286684343 @default.
- W2065431406 doi "https://doi.org/10.1097/01.rhu.0000081470.31167.8b" @default.
- W2065431406 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17041461" @default.
- W2065431406 hasPublicationYear "2003" @default.
- W2065431406 type Work @default.
- W2065431406 sameAs 2065431406 @default.
- W2065431406 citedByCount "25" @default.
- W2065431406 countsByYear W20654314062012 @default.
- W2065431406 countsByYear W20654314062013 @default.
- W2065431406 countsByYear W20654314062014 @default.
- W2065431406 countsByYear W20654314062015 @default.
- W2065431406 countsByYear W20654314062016 @default.
- W2065431406 countsByYear W20654314062017 @default.
- W2065431406 countsByYear W20654314062018 @default.
- W2065431406 countsByYear W20654314062019 @default.
- W2065431406 countsByYear W20654314062021 @default.
- W2065431406 countsByYear W20654314062022 @default.
- W2065431406 crossrefType "journal-article" @default.
- W2065431406 hasAuthorship W2065431406A5004595376 @default.
- W2065431406 hasAuthorship W2065431406A5035309374 @default.
- W2065431406 hasConcept C10146269 @default.
- W2065431406 hasConcept C126322002 @default.
- W2065431406 hasConcept C126894567 @default.
- W2065431406 hasConcept C134018914 @default.
- W2065431406 hasConcept C185592680 @default.
- W2065431406 hasConcept C2775905006 @default.
- W2065431406 hasConcept C2777575956 @default.
- W2065431406 hasConcept C2778076174 @default.
- W2065431406 hasConcept C2779881121 @default.
- W2065431406 hasConcept C2780091579 @default.
- W2065431406 hasConcept C2780306776 @default.
- W2065431406 hasConcept C2780402116 @default.
- W2065431406 hasConcept C56906281 @default.
- W2065431406 hasConcept C71924100 @default.
- W2065431406 hasConceptScore W2065431406C10146269 @default.
- W2065431406 hasConceptScore W2065431406C126322002 @default.
- W2065431406 hasConceptScore W2065431406C126894567 @default.
- W2065431406 hasConceptScore W2065431406C134018914 @default.
- W2065431406 hasConceptScore W2065431406C185592680 @default.
- W2065431406 hasConceptScore W2065431406C2775905006 @default.
- W2065431406 hasConceptScore W2065431406C2777575956 @default.
- W2065431406 hasConceptScore W2065431406C2778076174 @default.
- W2065431406 hasConceptScore W2065431406C2779881121 @default.
- W2065431406 hasConceptScore W2065431406C2780091579 @default.
- W2065431406 hasConceptScore W2065431406C2780306776 @default.
- W2065431406 hasConceptScore W2065431406C2780402116 @default.
- W2065431406 hasConceptScore W2065431406C56906281 @default.
- W2065431406 hasConceptScore W2065431406C71924100 @default.
- W2065431406 hasIssue "4" @default.
- W2065431406 hasLocation W20654314061 @default.
- W2065431406 hasLocation W20654314062 @default.
- W2065431406 hasOpenAccess W2065431406 @default.
- W2065431406 hasPrimaryLocation W20654314061 @default.
- W2065431406 hasRelatedWork W1974479570 @default.
- W2065431406 hasRelatedWork W1977802778 @default.
- W2065431406 hasRelatedWork W2003580807 @default.
- W2065431406 hasRelatedWork W2065431406 @default.
- W2065431406 hasRelatedWork W2147433151 @default.
- W2065431406 hasRelatedWork W2170170854 @default.
- W2065431406 hasRelatedWork W2362653257 @default.
- W2065431406 hasRelatedWork W251289532 @default.
- W2065431406 hasRelatedWork W2748952813 @default.
- W2065431406 hasRelatedWork W4384154010 @default.
- W2065431406 hasVolume "9" @default.
- W2065431406 isParatext "false" @default.
- W2065431406 isRetracted "false" @default.
- W2065431406 magId "2065431406" @default.
- W2065431406 workType "article" @default.