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- W2065431966 abstract "The binding of labeled carcinogen [3H]DMBA to murine epidermal cells (MEC) DNA in culture has been studied. The influence of unlabeled non-carcinogenic and carcinogenic polycyclic aromatic hydrocarbons (PAH), several PAH metabolites, and various directly and indirectly acting non-PAH carcinogens on the binding of [3H]DMBA to MEC DNA has been examined. All the carcinogenic PAH and some of non-carcinogenic PAH effectively inhibit the binding of [3H]DMBA to MEC DNA. The non-PAH chemical carcinogens requiring metabolic activation also reduce the binding of labeled DMBA to MEC DNA; however, a higher concentration of these compounds is required for 50% inhibition of binding than the concentrations of PAH for the same degree of inhibition of binding of [3H]DMBA to MEC DNA. The directly acting carcinogens do not significantly inhibit the binding of [3H]DMBA to DNA. The relationship between structures of PAH and their ability to inhibit the binding of [3H]DMBA to MEC DNA is also discussed. Thus, it appears that the binding of DMBA to cellular DNA is primarily controlled at a level of metabolism and to some extent at the level of binding of reactive metabolites to DNA." @default.
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- W2065431966 date "1979-11-01" @default.
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- W2065431966 title "Regulation of the binding of 7,12-dimethylbenz[a]anthracene to DNA of cultured murine epidermal cells at metabolic level: Competition of the binding by polycyclic aromatic hydrocarbons and by other precarcinogens" @default.
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- W2065431966 doi "https://doi.org/10.1016/0009-2797(79)90113-3" @default.
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