FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065432433> ?p ?o ?g. }

• W2065432433 endingPage "9410" @default.
• W2065432433 startingPage "9402" @default.
• W2065432433 abstract "Activity-dependent gene expression mediating changes of synaptic efficacy is important for memory storage, but the mechanisms underlying gene transcriptional changes in age-related memory disorders are poorly understood. In this study, we report that gene transcription mediated by the cAMP-response element binding protein (CREB)-regulated transcription coactivator CRTC1 is impaired in neurons and brain from an Alzheimer9s disease (AD) transgenic mouse expressing the human β-amyloid precursor protein (APP_Sw,Ind). Suppression of CRTC1-dependent gene transcription by β-amyloid (Aβ) in response to cAMP and Ca²⁺ signals is mediated by reduced calcium influx and disruption of PP2B/calcineurin-dependent CRTC1 dephosphorylation at Ser151. Consistently, expression of CRTC1 or active CRTC1 S151A and calcineurin mutants reverse the deficits on CRTC1 transcriptional activity in APP_Sw,Ind neurons. Inhibition of calcium influx by pharmacological blockade of L-type voltage-gated calcium channels (VGCCs), but not by blocking NMDA or AMPA receptors, mimics the decrease on CRTC1 transcriptional activity observed in APP_Sw,Ind neurons, whereas agonists of L-type VGCCs reverse efficiently these deficits. Consistent with a role of CRTC1 on Aβ-induced synaptic and memory dysfunction, we demonstrate a selective reduction of CRTC1-dependent genes related to memory (Bdnf, c-fos, and Nr4a2) coinciding with hippocampal-dependent spatial memory deficits in APP_Sw,Ind mice. These findings suggest that CRTC1 plays a key role in coupling synaptic activity to gene transcription required for hippocampal-dependent memory, and that Aβ could disrupt cognition by affecting CRTC1 function." @default.
• W2065432433 created "2016-06-24" @default.
• W2065432433 creator A5012378779 @default.
• W2065432433 creator A5012862119 @default.
• W2065432433 creator A5013960411 @default.
• W2065432433 creator A5021418181 @default.
• W2065432433 creator A5062474865 @default.
• W2065432433 creator A5064941762 @default.
• W2065432433 creator A5069412405 @default.
• W2065432433 creator A5075862295 @default.
• W2065432433 creator A5078083717 @default.
• W2065432433 creator A5081313788 @default.
• W2065432433 date "2010-07-14" @default.
• W2065432433 modified "2023-10-18" @default.
• W2065432433 title " -Amyloid Disrupts Activity-Dependent Gene Transcription Required for Memory through the CREB Coactivator CRTC1" @default.
• W2065432433 cites W1488313827 @default.
• W2065432433 cites W1529986832 @default.
• W2065432433 cites W1584834830 @default.
• W2065432433 cites W1948557773 @default.
• W2065432433 cites W1965014584 @default.
• W2065432433 cites W1970164987 @default.
• W2065432433 cites W1971570784 @default.
• W2065432433 cites W1977390447 @default.
• W2065432433 cites W1979270142 @default.
• W2065432433 cites W1980750700 @default.
• W2065432433 cites W1980968246 @default.
• W2065432433 cites W1985359216 @default.
• W2065432433 cites W1991131678 @default.
• W2065432433 cites W1992476409 @default.
• W2065432433 cites W2003320905 @default.
• W2065432433 cites W2009661936 @default.
• W2065432433 cites W2014719301 @default.
• W2065432433 cites W2016518696 @default.
• W2065432433 cites W2016678016 @default.
• W2065432433 cites W2021571918 @default.
• W2065432433 cites W2022103979 @default.
• W2065432433 cites W2028242823 @default.
• W2065432433 cites W2029203878 @default.
• W2065432433 cites W2033529039 @default.
• W2065432433 cites W2034986487 @default.
• W2065432433 cites W2041512157 @default.
• W2065432433 cites W2042069812 @default.
• W2065432433 cites W2048685634 @default.
• W2065432433 cites W2049134173 @default.
• W2065432433 cites W2051435398 @default.
• W2065432433 cites W2052096221 @default.
• W2065432433 cites W2055979394 @default.
• W2065432433 cites W2058861807 @default.
• W2065432433 cites W2059436430 @default.
• W2065432433 cites W2062022610 @default.
• W2065432433 cites W2064751459 @default.
• W2065432433 cites W2064958479 @default.
• W2065432433 cites W2065420555 @default.
• W2065432433 cites W2066842810 @default.
• W2065432433 cites W2069527370 @default.
• W2065432433 cites W2070881916 @default.
• W2065432433 cites W2071610467 @default.
• W2065432433 cites W2073984182 @default.
• W2065432433 cites W2075725519 @default.
• W2065432433 cites W2076968916 @default.
• W2065432433 cites W2078917784 @default.
• W2065432433 cites W2078962110 @default.
• W2065432433 cites W2081704409 @default.
• W2065432433 cites W2088359631 @default.
• W2065432433 cites W2094958540 @default.
• W2065432433 cites W2096397256 @default.
• W2065432433 cites W2100407725 @default.
• W2065432433 cites W2106726734 @default.
• W2065432433 cites W2109807917 @default.
• W2065432433 cites W2114926230 @default.
• W2065432433 cites W2119875949 @default.
• W2065432433 cites W2125269304 @default.
• W2065432433 cites W2128103118 @default.
• W2065432433 cites W2128401893 @default.
• W2065432433 cites W2131041787 @default.
• W2065432433 cites W2133083344 @default.
• W2065432433 cites W2136827845 @default.
• W2065432433 cites W2142186280 @default.
• W2065432433 cites W2147989304 @default.
• W2065432433 cites W2158590037 @default.
• W2065432433 cites W2161109512 @default.
• W2065432433 cites W2164975702 @default.
• W2065432433 cites W2168334242 @default.
• W2065432433 cites W2171344422 @default.
• W2065432433 cites W2184203459 @default.
• W2065432433 doi "https://doi.org/10.1523/jneurosci.2154-10.2010" @default.
• W2065432433 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6632424" @default.
• W2065432433 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20631169" @default.
• W2065432433 hasPublicationYear "2010" @default.
• W2065432433 type Work @default.
• W2065432433 sameAs 2065432433 @default.
• W2065432433 citedByCount "100" @default.
• W2065432433 countsByYear W20654324332012 @default.
• W2065432433 countsByYear W20654324332013 @default.
• W2065432433 countsByYear W20654324332014 @default.
• W2065432433 countsByYear W20654324332015 @default.
• W2065432433 countsByYear W20654324332016 @default.
• W2065432433 countsByYear W20654324332017 @default.

• next