FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065432788> ?p ?o ?g. }

• W2065432788 endingPage "1760" @default.
• W2065432788 startingPage "1755" @default.
• W2065432788 abstract "The hypernociceptive effects of cytokines [TNF-alpha, keratinocyte-derived chemokine (KC), and IL-1beta] and their participation in carrageenan (Cg)-induced inflammatory hypernociception in mice were investigated. Nociceptor sensitization (hypernociception) was quantified with an electronic version of the von Frey filament test in WT and TNF receptor type 1 knockout mice (TNF-R1-/-). TNF-alpha-induced hypernociception was abolished in TNF-R1-/- mice, partially inhibited by pretreatment with IL-1 receptor antagonist (IL-1ra) or indomethacin and unaffected by Ab against KC (AbKC) or guanethidine. IL-1ra and indomethacin pretreatment strongly inhibited the hypernociception induced by IL-1beta, which was not altered by AbKC or guanethidine or by knocking out TNF-R1. KC-induced hypernociception was abolished by AbKC, inhibited by pretreatment with indomethacin plus guanethidine, and partially inhibited by IL-1ra, indomethacin, or guanethidine. In contrast, KC-induced hypernociception was not altered by knocking out TNF-R1. Cg-induced hypernociception was abolished by administration of indomethacin plus guanethidine, diminished in TNF-R1-/- mice, and partially inhibited in WT mice pretreated with AbKC, IL-1ra, indomethacin, or guanethidine. TNF-alpha, KC, and IL-1beta concentrations were elevated in the skin of Cg-injected paws. The TNF-alpha and KC concentrations rose concomitantly and peaked before that of IL-1beta. In mice, the cytokine cascade begins with the release of TNF-alpha (acting on TNF-R1 receptor) and KC, which stimulate the release of IL-1beta. As in rats, the final mediators of this cascade were prostaglandins released by IL-1beta and sympathetic amines released by KC. These results extend to mice the concept that the release of primary mediators responsible for hypernociception is preceded by a cascade of cytokines." @default.
• W2065432788 created "2016-06-24" @default.
• W2065432788 creator A5017615120 @default.
• W2065432788 creator A5026715333 @default.
• W2065432788 creator A5031690868 @default.
• W2065432788 creator A5061812047 @default.
• W2065432788 creator A5075415353 @default.
• W2065432788 creator A5078024039 @default.
• W2065432788 date "2005-01-21" @default.
• W2065432788 modified "2023-10-14" @default.
• W2065432788 title "A cascade of cytokines mediates mechanical inflammatory hypernociception in mice" @default.
• W2065432788 cites W1503834335 @default.
• W2065432788 cites W1574929990 @default.
• W2065432788 cites W1715662620 @default.
• W2065432788 cites W1780460389 @default.
• W2065432788 cites W1883044208 @default.
• W2065432788 cites W191908788 @default.
• W2065432788 cites W1946072432 @default.
• W2065432788 cites W1963760749 @default.
• W2065432788 cites W1968412196 @default.
• W2065432788 cites W1976909984 @default.
• W2065432788 cites W1978515480 @default.
• W2065432788 cites W1978560640 @default.
• W2065432788 cites W1978939719 @default.
• W2065432788 cites W1979469744 @default.
• W2065432788 cites W1979810543 @default.
• W2065432788 cites W1980601649 @default.
• W2065432788 cites W1984632338 @default.
• W2065432788 cites W1987329204 @default.
• W2065432788 cites W2000468755 @default.
• W2065432788 cites W2001699192 @default.
• W2065432788 cites W2004755236 @default.
• W2065432788 cites W2006785548 @default.
• W2065432788 cites W2018683912 @default.
• W2065432788 cites W2022031142 @default.
• W2065432788 cites W202476683 @default.
• W2065432788 cites W2029227926 @default.
• W2065432788 cites W2031811175 @default.
• W2065432788 cites W2032683573 @default.
• W2065432788 cites W2042643335 @default.
• W2065432788 cites W2045280233 @default.
• W2065432788 cites W2047955328 @default.
• W2065432788 cites W2049009553 @default.
• W2065432788 cites W2050196051 @default.
• W2065432788 cites W2062931550 @default.
• W2065432788 cites W2065355734 @default.
• W2065432788 cites W2066838089 @default.
• W2065432788 cites W2068898733 @default.
• W2065432788 cites W2069742985 @default.
• W2065432788 cites W2071513511 @default.
• W2065432788 cites W2079385252 @default.
• W2065432788 cites W2088712966 @default.
• W2065432788 cites W2116117473 @default.
• W2065432788 cites W2116142178 @default.
• W2065432788 cites W2123258170 @default.
• W2065432788 cites W2124522161 @default.
• W2065432788 cites W2134814434 @default.
• W2065432788 cites W2137686732 @default.
• W2065432788 cites W2143939606 @default.
• W2065432788 cites W2154232005 @default.
• W2065432788 cites W2171223432 @default.
• W2065432788 cites W2261395449 @default.
• W2065432788 cites W3023923910 @default.
• W2065432788 cites W4296792904 @default.
• W2065432788 doi "https://doi.org/10.1073/pnas.0409225102" @default.
• W2065432788 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/547882" @default.
• W2065432788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15665080" @default.
• W2065432788 hasPublicationYear "2005" @default.
• W2065432788 type Work @default.
• W2065432788 sameAs 2065432788 @default.
• W2065432788 citedByCount "517" @default.
• W2065432788 countsByYear W20654327882012 @default.
• W2065432788 countsByYear W20654327882013 @default.
• W2065432788 countsByYear W20654327882014 @default.
• W2065432788 countsByYear W20654327882015 @default.
• W2065432788 countsByYear W20654327882016 @default.
• W2065432788 countsByYear W20654327882017 @default.
• W2065432788 countsByYear W20654327882018 @default.
• W2065432788 countsByYear W20654327882019 @default.
• W2065432788 countsByYear W20654327882020 @default.
• W2065432788 countsByYear W20654327882021 @default.
• W2065432788 countsByYear W20654327882022 @default.
• W2065432788 countsByYear W20654327882023 @default.
• W2065432788 crossrefType "journal-article" @default.
• W2065432788 hasAuthorship W2065432788A5017615120 @default.
• W2065432788 hasAuthorship W2065432788A5026715333 @default.
• W2065432788 hasAuthorship W2065432788A5031690868 @default.
• W2065432788 hasAuthorship W2065432788A5061812047 @default.
• W2065432788 hasAuthorship W2065432788A5075415353 @default.
• W2065432788 hasAuthorship W2065432788A5078024039 @default.
• W2065432788 hasBestOaLocation W20654327882 @default.
• W2065432788 hasConcept C126322002 @default.
• W2065432788 hasConcept C134018914 @default.
• W2065432788 hasConcept C15490471 @default.
• W2065432788 hasConcept C170493617 @default.
• W2065432788 hasConcept C17991360 @default.
• W2065432788 hasConcept C185592680 @default.
• W2065432788 hasConcept C24998067 @default.

• next