Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065436327> ?p ?o ?g. }
- W2065436327 endingPage "101" @default.
- W2065436327 startingPage "96" @default.
- W2065436327 abstract "Our laboratory has developed an in vivo method to quantitatively evaluate phospholipase A(2) (PLA(2))-mediated signal transduction in brain regions of rodents. In this method, quantitative autoradiography is used to identify brain uptake of intravenously injected, radiolabeled arachidonic acid ([3H]AA). Dopamine D(2) receptors are coupled to G-proteins that activate PLA(2), releasing AA from the stereospecifically numbered (sn) 2 position of phospholipids, and regional [3H]AA uptake is proportional to the rate of release. In the present experiment, the D(2) antagonist haloperidol (1.0 mg/kg i.p.) or the drug vehicle was administered to male adult rats for 21 days. Rats were infused 3 days later with 1.75 mCi/kg [3H]AA (i.v.), anesthetized and decapitated 20 min after infusion onset, and brains were processed for quantitative autoradiography. Chronic haloperidol significantly decreased [3H]AA incorporation in two primary dopaminergic basal ganglia-frontal cortex circuits, the mesocorticolimbic and nigrostriatal systems, while insignificant changes in AA incorporation were noted in other brain regions. These results suggest that one mechanism by which haloperidol exerts its effect is by downregulating D(2)-mediated PLA(2) signaling involving AA release in basal ganglia-frontal cortex circuitry." @default.
- W2065436327 created "2016-06-24" @default.
- W2065436327 creator A5011234589 @default.
- W2065436327 creator A5013594664 @default.
- W2065436327 creator A5030979579 @default.
- W2065436327 creator A5044516569 @default.
- W2065436327 creator A5076260458 @default.
- W2065436327 date "2001-03-01" @default.
- W2065436327 modified "2023-09-27" @default.
- W2065436327 title "Haloperidol downregulates phospholipase A2 signaling in rat basal ganglia circuits" @default.
- W2065436327 cites W1975216040 @default.
- W2065436327 cites W1976700610 @default.
- W2065436327 cites W1980410488 @default.
- W2065436327 cites W1981008737 @default.
- W2065436327 cites W1981806827 @default.
- W2065436327 cites W1992840579 @default.
- W2065436327 cites W1993408250 @default.
- W2065436327 cites W1994148919 @default.
- W2065436327 cites W1996020517 @default.
- W2065436327 cites W1996735957 @default.
- W2065436327 cites W2009295700 @default.
- W2065436327 cites W2009447429 @default.
- W2065436327 cites W2010316443 @default.
- W2065436327 cites W2010642455 @default.
- W2065436327 cites W2023130029 @default.
- W2065436327 cites W2031989283 @default.
- W2065436327 cites W2033406189 @default.
- W2065436327 cites W2035914400 @default.
- W2065436327 cites W2039736891 @default.
- W2065436327 cites W2049977718 @default.
- W2065436327 cites W2055870207 @default.
- W2065436327 cites W2061522518 @default.
- W2065436327 cites W2066136648 @default.
- W2065436327 cites W2068346256 @default.
- W2065436327 cites W2069098762 @default.
- W2065436327 cites W2075412000 @default.
- W2065436327 cites W2075946390 @default.
- W2065436327 cites W2081182033 @default.
- W2065436327 cites W2081485883 @default.
- W2065436327 cites W2087269009 @default.
- W2065436327 cites W2093960552 @default.
- W2065436327 cites W2142732083 @default.
- W2065436327 cites W2142918202 @default.
- W2065436327 cites W2148418924 @default.
- W2065436327 cites W2149860264 @default.
- W2065436327 cites W2159685569 @default.
- W2065436327 cites W2171688276 @default.
- W2065436327 doi "https://doi.org/10.1016/s0006-8993(01)02014-5" @default.
- W2065436327 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11277978" @default.
- W2065436327 hasPublicationYear "2001" @default.
- W2065436327 type Work @default.
- W2065436327 sameAs 2065436327 @default.
- W2065436327 citedByCount "15" @default.
- W2065436327 countsByYear W20654363272021 @default.
- W2065436327 crossrefType "journal-article" @default.
- W2065436327 hasAuthorship W2065436327A5011234589 @default.
- W2065436327 hasAuthorship W2065436327A5013594664 @default.
- W2065436327 hasAuthorship W2065436327A5030979579 @default.
- W2065436327 hasAuthorship W2065436327A5044516569 @default.
- W2065436327 hasAuthorship W2065436327A5076260458 @default.
- W2065436327 hasConcept C126322002 @default.
- W2065436327 hasConcept C134018914 @default.
- W2065436327 hasConcept C137183658 @default.
- W2065436327 hasConcept C181199279 @default.
- W2065436327 hasConcept C185592680 @default.
- W2065436327 hasConcept C2776551241 @default.
- W2065436327 hasConcept C2778078955 @default.
- W2065436327 hasConcept C2778187257 @default.
- W2065436327 hasConcept C2780062018 @default.
- W2065436327 hasConcept C2780948584 @default.
- W2065436327 hasConcept C513476851 @default.
- W2065436327 hasConcept C529278444 @default.
- W2065436327 hasConcept C55493867 @default.
- W2065436327 hasConcept C71924100 @default.
- W2065436327 hasConcept C86803240 @default.
- W2065436327 hasConceptScore W2065436327C126322002 @default.
- W2065436327 hasConceptScore W2065436327C134018914 @default.
- W2065436327 hasConceptScore W2065436327C137183658 @default.
- W2065436327 hasConceptScore W2065436327C181199279 @default.
- W2065436327 hasConceptScore W2065436327C185592680 @default.
- W2065436327 hasConceptScore W2065436327C2776551241 @default.
- W2065436327 hasConceptScore W2065436327C2778078955 @default.
- W2065436327 hasConceptScore W2065436327C2778187257 @default.
- W2065436327 hasConceptScore W2065436327C2780062018 @default.
- W2065436327 hasConceptScore W2065436327C2780948584 @default.
- W2065436327 hasConceptScore W2065436327C513476851 @default.
- W2065436327 hasConceptScore W2065436327C529278444 @default.
- W2065436327 hasConceptScore W2065436327C55493867 @default.
- W2065436327 hasConceptScore W2065436327C71924100 @default.
- W2065436327 hasConceptScore W2065436327C86803240 @default.
- W2065436327 hasIssue "1-2" @default.
- W2065436327 hasLocation W20654363271 @default.
- W2065436327 hasLocation W20654363272 @default.
- W2065436327 hasOpenAccess W2065436327 @default.
- W2065436327 hasPrimaryLocation W20654363271 @default.
- W2065436327 hasRelatedWork W2006136814 @default.
- W2065436327 hasRelatedWork W2017638447 @default.
- W2065436327 hasRelatedWork W2027596383 @default.