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- W2065439630 abstract "The defining feature of Parkinson's disease is a progressive and selective demise of dopaminergic neurons. A recent report on Parkinson's disease animal model demonstrates that poly (ADP-ribose) (PAR) dependent cell death, also named parthanatos, is accountable for selective dopaminergic neuronal loss. Parthanatos is a programmed necrotic cell death, characterized by PARP1 activation, apoptosis inducing factor (AIF) nuclear translocation, and large scale DNA fragmentation. Besides cell death regulation via interaction with AIF, PAR molecule mediates diverse cellular processes including genomic stability, cell division, transcription, epigenetic regulation, and stress granule formation. In this review, we will discuss the roles of PARP1 activation and PAR molecules in the pathological processes of Parkinson's disease. Potential interaction between PAR molecule and Parkinson's disease protein interactome are briefly introduced. Finally, we suggest promising points of therapeutic intervention in the pathological PAR signaling cascade to halt progression in Parkinson's disease." @default.
- W2065439630 created "2016-06-24" @default.
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- W2065439630 date "2014-08-31" @default.
- W2065439630 modified "2023-10-17" @default.
- W2065439630 title "Poly (ADP-ribose) in the pathogenesis of Parkinson's disease" @default.
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- W2065439630 doi "https://doi.org/10.5483/bmbrep.2014.47.8.119" @default.
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