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• W2065440627 abstract "<b><i><i>Objective:</i></i></b> To investigate whether vagus nerve stimulation (VNS) reduces pruritus in humans. <b><i><i>Background:</i></i></b> Recently, it has been shown that VNS has antinociceptive and antidepressant effects in humans. <b><i><i>Methods:</i></i></b> Eleven patients were investigated before (baseline) and during chronic VNS treatment. The experiments were performed at two different stimulation intensities: 2 to 5 days after implantation at a low stimulation intensity (mean intensity 0.7 ± 0.2 mA, second session) and after 8 to 14 weeks of VNS therapy (mean intensity 1.4 ± 0.3 mA, third session). Twelve healthy age- and sex-matched subjects were investigated using the same experimental protocol. Itch was induced by histamine–iontophoresis and quantified on a visual analogue scale (VAS). Histamine-induced flare was quantified using laser–Doppler flowmetry. <b><i><i>Results:</i></i></b> Itch was reduced by VNS from 24 ± 8% VAS at baseline to 15 ± 5% VAS at second session, and 19 ± 8% VAS at third session (<i>p</i> < 0.05 multivariate analysis of variance). In the control group, itch remained unaltered in all three sessions (26 ± 5% at baseline, 23 ± 5% in the second session, and 25 ± 5% in the third session, not significant). The flare was unaltered in both patients and control subjects. <b><i><i>Conclusions:</i></i></b> VNS may suppress pruritus in humans." @default.
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• W2065440627 date "2006-11-27" @default.
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• W2065440627 title "Blockade of chemokine signaling in patients with multiple sclerosis" @default.
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• W2065440627 doi "https://doi.org/10.1212/01.wnl.0000244420.68037.86" @default.
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