FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065442220> ?p ?o ?g. }

• W2065442220 endingPage "842" @default.
• W2065442220 startingPage "835" @default.
• W2065442220 abstract "Dexamethasone, a potent synthetic glucocorticoid, has been shown to increase polymeric immunoglobulin A (IgA) and antigen-specific IgA antibody levels in serum. This response coincided with a decline in IgA and IgG levels in saliva and vaginal secretions after dexamethasone treatment. To investigate the mechanism(s) of glucocorticoid action responsible for the accumulation of polymeric IgA in serum, we undertook in the present study to determine whether dexamethasone alters the production of secretory component (SC). SC is the receptor responsible for transporting IgA from blood and tissues into bile and external secretions. Dexamethasone administered in vivo increased SC levels in serum in a dose- and time-dependent manner. When bile and saliva samples were analyzed, dexamethasone treatment increased saliva SC levels and the production rate of SC by the liver, but had a pronounced inhibitory effect on both bile and salivary levels of IgA. As judged by HPLC, the majority of SC in blood was associated with polymeric IgA and not with monomeric IgA. Immunoblots showed the presence of a 29/27K doublet band of SC in serum from control- and dexamethasone-stimulated rats. These findings indicate that the elevation of polymeric IgA levels in serum after dexamethasone treatment may be due to decreased clearance of IgA into bile. Further, it demonstrates that liver production rate of SC as well as saliva and serum SC levels increase with glucocorticoid treatment. This finding suggests that glucocorticoids, which are known to stimulate hepatocyte SC synthesis in vitro, increase SC levels in blood, possibly as SC fragments that are capable of binding polymeric IgA and retarding its clearance from blood to bile. (Endocrinology128: 835–842, 1991)" @default.
• W2065442220 created "2016-06-24" @default.
• W2065442220 creator A5017248220 @default.
• W2065442220 creator A5046970570 @default.
• W2065442220 date "1991-02-01" @default.
• W2065442220 modified "2023-10-18" @default.
• W2065442220 title "Glucocorticoid Regulation of the Humoral Immune System. Dexamethasone Stimulation of Secretory Component in Serum, Saliva, and Bile*" @default.
• W2065442220 cites W127641069 @default.
• W2065442220 cites W1525248753 @default.
• W2065442220 cites W1552635305 @default.
• W2065442220 cites W1564824824 @default.
• W2065442220 cites W1579745781 @default.
• W2065442220 cites W1580742681 @default.
• W2065442220 cites W1882949371 @default.
• W2065442220 cites W1901089512 @default.
• W2065442220 cites W1949482848 @default.
• W2065442220 cites W1958503896 @default.
• W2065442220 cites W1968111694 @default.
• W2065442220 cites W1971389550 @default.
• W2065442220 cites W1972076005 @default.
• W2065442220 cites W1978530778 @default.
• W2065442220 cites W1980743427 @default.
• W2065442220 cites W1986208323 @default.
• W2065442220 cites W2002581726 @default.
• W2065442220 cites W2017701535 @default.
• W2065442220 cites W2019509866 @default.
• W2065442220 cites W2022177279 @default.
• W2065442220 cites W2025296308 @default.
• W2065442220 cites W2043285346 @default.
• W2065442220 cites W2065469966 @default.
• W2065442220 cites W2067683972 @default.
• W2065442220 cites W2073143598 @default.
• W2065442220 cites W2074381499 @default.
• W2065442220 cites W2082281582 @default.
• W2065442220 cites W2085112043 @default.
• W2065442220 cites W2087610426 @default.
• W2065442220 cites W2100219986 @default.
• W2065442220 cites W2105523461 @default.
• W2065442220 cites W2113276215 @default.
• W2065442220 cites W2126210741 @default.
• W2065442220 cites W2141376249 @default.
• W2065442220 cites W2218445317 @default.
• W2065442220 cites W2249654069 @default.
• W2065442220 cites W2275166293 @default.
• W2065442220 cites W2404270038 @default.
• W2065442220 cites W2429814667 @default.
• W2065442220 cites W2911430026 @default.
• W2065442220 cites W343568803 @default.
• W2065442220 cites W62771806 @default.
• W2065442220 cites W94164384 @default.
• W2065442220 cites W96329196 @default.
• W2065442220 doi "https://doi.org/10.1210/endo-128-2-835" @default.
• W2065442220 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1989865" @default.
• W2065442220 hasPublicationYear "1991" @default.
• W2065442220 type Work @default.
• W2065442220 sameAs 2065442220 @default.
• W2065442220 citedByCount "35" @default.
• W2065442220 countsByYear W20654422202015 @default.
• W2065442220 countsByYear W20654422202017 @default.
• W2065442220 crossrefType "journal-article" @default.
• W2065442220 hasAuthorship W2065442220A5017248220 @default.
• W2065442220 hasAuthorship W2065442220A5046970570 @default.
• W2065442220 hasConcept C126322002 @default.
• W2065442220 hasConcept C134018914 @default.
• W2065442220 hasConcept C150903083 @default.
• W2065442220 hasConcept C159654299 @default.
• W2065442220 hasConcept C185592680 @default.
• W2065442220 hasConcept C203014093 @default.
• W2065442220 hasConcept C207001950 @default.
• W2065442220 hasConcept C24998067 @default.
• W2065442220 hasConcept C2776888042 @default.
• W2065442220 hasConcept C2779102806 @default.
• W2065442220 hasConcept C2780401358 @default.
• W2065442220 hasConcept C2780841215 @default.
• W2065442220 hasConcept C2780898057 @default.
• W2065442220 hasConcept C504460877 @default.
• W2065442220 hasConcept C59493245 @default.
• W2065442220 hasConcept C71315377 @default.
• W2065442220 hasConcept C71924100 @default.
• W2065442220 hasConcept C86803240 @default.
• W2065442220 hasConcept C8891405 @default.
• W2065442220 hasConceptScore W2065442220C126322002 @default.
• W2065442220 hasConceptScore W2065442220C134018914 @default.
• W2065442220 hasConceptScore W2065442220C150903083 @default.
• W2065442220 hasConceptScore W2065442220C159654299 @default.
• W2065442220 hasConceptScore W2065442220C185592680 @default.
• W2065442220 hasConceptScore W2065442220C203014093 @default.
• W2065442220 hasConceptScore W2065442220C207001950 @default.
• W2065442220 hasConceptScore W2065442220C24998067 @default.
• W2065442220 hasConceptScore W2065442220C2776888042 @default.
• W2065442220 hasConceptScore W2065442220C2779102806 @default.
• W2065442220 hasConceptScore W2065442220C2780401358 @default.
• W2065442220 hasConceptScore W2065442220C2780841215 @default.
• W2065442220 hasConceptScore W2065442220C2780898057 @default.
• W2065442220 hasConceptScore W2065442220C504460877 @default.
• W2065442220 hasConceptScore W2065442220C59493245 @default.
• W2065442220 hasConceptScore W2065442220C71315377 @default.
• W2065442220 hasConceptScore W2065442220C71924100 @default.

• next