FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065443658> ?p ?o ?g. }

• W2065443658 endingPage "1002" @default.
• W2065443658 startingPage "997" @default.
• W2065443658 abstract "A series of potent, selective platelet-derived growth factor receptor-family kinase inhibitors was optimized starting from a globally selective lead molecule 4 through structural modifications aimed at improving the physiochemical and pharmacokinetic properties, as exemplified by 18b. Further clearance reduction via per-methylation of the α-carbons of a solubilizing piperidine nitrogen resulted in advanced leads 22a and 22b. Results from a mouse tumor xenograft, a collagen-induced arthritis model, and a 7 day rat in vivo tolerability study culminated in the selection of compound 22b (AC710) as a preclinical development candidate." @default.
• W2065443658 created "2016-06-24" @default.
• W2065443658 creator A5015604675 @default.
• W2065443658 creator A5015710627 @default.
• W2065443658 creator A5021209882 @default.
• W2065443658 creator A5028958964 @default.
• W2065443658 creator A5029720227 @default.
• W2065443658 creator A5033815247 @default.
• W2065443658 creator A5047530938 @default.
• W2065443658 creator A5056916898 @default.
• W2065443658 creator A5058637832 @default.
• W2065443658 creator A5066359360 @default.
• W2065443658 creator A5072227841 @default.
• W2065443658 creator A5080681310 @default.
• W2065443658 creator A5087085239 @default.
• W2065443658 date "2012-09-28" @default.
• W2065443658 modified "2023-10-16" @default.
• W2065443658 title "Discovery of AC710, a Globally Selective Inhibitor of Platelet-Derived Growth Factor Receptor-Family Kinases" @default.
• W2065443658 cites W1555276708 @default.
• W2065443658 cites W1965696083 @default.
• W2065443658 cites W1966007200 @default.
• W2065443658 cites W1968796843 @default.
• W2065443658 cites W1970264868 @default.
• W2065443658 cites W1973207799 @default.
• W2065443658 cites W1978890358 @default.
• W2065443658 cites W1981706397 @default.
• W2065443658 cites W2011187792 @default.
• W2065443658 cites W2016934021 @default.
• W2065443658 cites W2019333269 @default.
• W2065443658 cites W2020103132 @default.
• W2065443658 cites W2024725966 @default.
• W2065443658 cites W2028160054 @default.
• W2065443658 cites W2032410318 @default.
• W2065443658 cites W2033472212 @default.
• W2065443658 cites W2048361602 @default.
• W2065443658 cites W2057907407 @default.
• W2065443658 cites W2086286404 @default.
• W2065443658 cites W2098280147 @default.
• W2065443658 cites W2129018264 @default.
• W2065443658 cites W2142776762 @default.
• W2065443658 cites W2144242611 @default.
• W2065443658 cites W2149142217 @default.
• W2065443658 cites W2151222524 @default.
• W2065443658 cites W2550440453 @default.
• W2065443658 cites W4211075026 @default.
• W2065443658 doi "https://doi.org/10.1021/ml300214g" @default.
• W2065443658 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4025831" @default.
• W2065443658 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24900421" @default.
• W2065443658 hasPublicationYear "2012" @default.
• W2065443658 type Work @default.
• W2065443658 sameAs 2065443658 @default.
• W2065443658 citedByCount "8" @default.
• W2065443658 countsByYear W20654436582014 @default.
• W2065443658 countsByYear W20654436582015 @default.
• W2065443658 countsByYear W20654436582017 @default.
• W2065443658 countsByYear W20654436582018 @default.
• W2065443658 countsByYear W20654436582019 @default.
• W2065443658 countsByYear W20654436582022 @default.
• W2065443658 countsByYear W20654436582023 @default.
• W2065443658 crossrefType "journal-article" @default.
• W2065443658 hasAuthorship W2065443658A5015604675 @default.
• W2065443658 hasAuthorship W2065443658A5015710627 @default.
• W2065443658 hasAuthorship W2065443658A5021209882 @default.
• W2065443658 hasAuthorship W2065443658A5028958964 @default.
• W2065443658 hasAuthorship W2065443658A5029720227 @default.
• W2065443658 hasAuthorship W2065443658A5033815247 @default.
• W2065443658 hasAuthorship W2065443658A5047530938 @default.
• W2065443658 hasAuthorship W2065443658A5056916898 @default.
• W2065443658 hasAuthorship W2065443658A5058637832 @default.
• W2065443658 hasAuthorship W2065443658A5066359360 @default.
• W2065443658 hasAuthorship W2065443658A5072227841 @default.
• W2065443658 hasAuthorship W2065443658A5080681310 @default.
• W2065443658 hasAuthorship W2065443658A5087085239 @default.
• W2065443658 hasBestOaLocation W20654436582 @default.
• W2065443658 hasConcept C112705442 @default.
• W2065443658 hasConcept C150903083 @default.
• W2065443658 hasConcept C170493617 @default.
• W2065443658 hasConcept C184235292 @default.
• W2065443658 hasConcept C185592680 @default.
• W2065443658 hasConcept C197934379 @default.
• W2065443658 hasConcept C207001950 @default.
• W2065443658 hasConcept C26375932 @default.
• W2065443658 hasConcept C2778375690 @default.
• W2065443658 hasConcept C502942594 @default.
• W2065443658 hasConcept C55493867 @default.
• W2065443658 hasConcept C71924100 @default.
• W2065443658 hasConcept C86803240 @default.
• W2065443658 hasConcept C98274493 @default.
• W2065443658 hasConceptScore W2065443658C112705442 @default.
• W2065443658 hasConceptScore W2065443658C150903083 @default.
• W2065443658 hasConceptScore W2065443658C170493617 @default.
• W2065443658 hasConceptScore W2065443658C184235292 @default.
• W2065443658 hasConceptScore W2065443658C185592680 @default.
• W2065443658 hasConceptScore W2065443658C197934379 @default.
• W2065443658 hasConceptScore W2065443658C207001950 @default.
• W2065443658 hasConceptScore W2065443658C26375932 @default.
• W2065443658 hasConceptScore W2065443658C2778375690 @default.
• W2065443658 hasConceptScore W2065443658C502942594 @default.

• next