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• W2065446325 abstract "We have examined the effects of glucose at high concentrations on the process of cell death induced by excessive increase in intracellular Ca2+ concentration ([Ca2+]i) or oxidative stress in rat lymphocytes. The cell death elicited by the excessive increase in [Ca2+]i seemed to be induced by an activation of Ca2+-dependent K+ channels because the inhibitors for Ca2+-dependent K+ channels attenuated the decrease in cell viability. Glucose at 30–50 mM augmented the decrease in cell viability by the excessive increase in [Ca2+]i. It was not specific for glucose because it was the case for sucrose or NaCl, suggesting an involvement of increased osmolarity in adverse action of glucose. On the contrary, glucose protected the cells suffering from oxidative stress induced by H2O2, one of reactive oxygen species. It was also the case for fructose or sucrose, but not for NaCl. The process of cell death induced by H2O2 started, being independent from the presence of glucose. Glucose delayed the process of cell death induced by H2O2. Sucrose and fructose also protected the cells against oxidative stress. The reactivity of sucrose to reactive oxygen species is lower than those of glucose and fructose. The order in the reactivity cannot explain the protective action of glucose. Glucose at high concentrations exerts reciprocal actions on the process of cell death induced by the oxidative stress and excessive increase in [Ca2+]i." @default.
• W2065446325 created "2016-06-24" @default.
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• W2065446325 date "2006-08-01" @default.
• W2065446325 modified "2023-09-22" @default.
• W2065446325 title "Reciprocal effects of glucose on the process of cell death induced by calcium ionophore or H2O2 in rat lymphocytes" @default.
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• W2065446325 doi "https://doi.org/10.1016/j.tox.2006.05.004" @default.
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