FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065448466> ?p ?o ?g. }

• W2065448466 endingPage "157" @default.
• W2065448466 startingPage "149" @default.
• W2065448466 abstract "The regulation of histamine synthesis was studied on rat brain slices or synaptosomes labeled with l-[3H]histidine. Depolarization by increased extracellular K+ concentration enhanced by about twofold the [3H]histamine formation in slices of cerebral cortex. This stimulation was also observed, although to a lesser extent, in synaptosomes from cerebral cortex and slices from the posterior hypothalamus where most histaminergic cell-bodies are located, suggesting that it may occur in nerve endings as well as in perikarya. In the presence of exogenous histamine in increasing concentrations the K+-induced stimulation was progressively reduced by up to 60–70%. The effect of exogenous histamine appears to be receptor-mediated as shown by its saturable character, high pharmacological specificity and competitive reversai by histamine antagonists. The ec50 value of histamine for synthesis reduction (0.34 ± 0.03 μM) was similar to its ec50 value for release inhibition known to be mediated by H3-receptors. In addition, whereas mepyramine and tiotidine, two potent antagonists at H1- and H2-receptors, respectively, were poorly effective, the H3-receptor antagonists burimamide and impromidine reversed the histamine effect in an apparently competitive manner. These effects were observed in slices of cerebral cortex or posterior hypothalamus as well as in cortical synaptosomes. Furthermore, even in the absence of added histamine, H3-receptor antagonists enhanced the depolarization-induced stimulation of [3H]histamine synthesis, indicating a participation of released endogenous histamine in the synthesis control process. The potencies of H3-receptor antagonists were similar to those of these agents at presynaptic autoreceptors controlling [3H]histamine release. It is concluded that H3-receptors control not only release but also synthesis of histamine at the Ievel of nerve endings and also, presumably, of perikarya. A relationship between the two regulatory processes, possibly via intracellular calcium, seems likely but remains to be investigated at the molecular Ievel." @default.
• W2065448466 created "2016-06-24" @default.
• W2065448466 creator A5042615490 @default.
• W2065448466 creator A5053447405 @default.
• W2065448466 creator A5053509756 @default.
• W2065448466 date "1987-10-01" @default.
• W2065448466 modified "2023-09-27" @default.
• W2065448466 title "Autoinhibition of histamine synthesis mediated by presynaptic H3-receptors" @default.
• W2065448466 cites W1775749144 @default.
• W2065448466 cites W1950855598 @default.
• W2065448466 cites W1966786998 @default.
• W2065448466 cites W1974147681 @default.
• W2065448466 cites W1974845204 @default.
• W2065448466 cites W1979857021 @default.
• W2065448466 cites W1980916014 @default.
• W2065448466 cites W1982264284 @default.
• W2065448466 cites W1988135430 @default.
• W2065448466 cites W1988385174 @default.
• W2065448466 cites W1996292246 @default.
• W2065448466 cites W1998402864 @default.
• W2065448466 cites W2001079294 @default.
• W2065448466 cites W2003774091 @default.
• W2065448466 cites W2006651052 @default.
• W2065448466 cites W2008632370 @default.
• W2065448466 cites W2014933011 @default.
• W2065448466 cites W2016805373 @default.
• W2065448466 cites W2024131993 @default.
• W2065448466 cites W2024238139 @default.
• W2065448466 cites W2025442996 @default.
• W2065448466 cites W2027465265 @default.
• W2065448466 cites W2028871143 @default.
• W2065448466 cites W2033832405 @default.
• W2065448466 cites W2034510833 @default.
• W2065448466 cites W2036305530 @default.
• W2065448466 cites W2036705306 @default.
• W2065448466 cites W2037174573 @default.
• W2065448466 cites W2043488740 @default.
• W2065448466 cites W2044830779 @default.
• W2065448466 cites W2045593282 @default.
• W2065448466 cites W2046302119 @default.
• W2065448466 cites W2046653273 @default.
• W2065448466 cites W2049062911 @default.
• W2065448466 cites W2051656979 @default.
• W2065448466 cites W2068286701 @default.
• W2065448466 cites W2071264712 @default.
• W2065448466 cites W2074631079 @default.
• W2065448466 cites W2075887314 @default.
• W2065448466 cites W2077687762 @default.
• W2065448466 cites W2078623903 @default.
• W2065448466 cites W2094407119 @default.
• W2065448466 cites W2094883365 @default.
• W2065448466 cites W2107839689 @default.
• W2065448466 cites W2149519103 @default.
• W2065448466 cites W2154514279 @default.
• W2065448466 cites W2154588586 @default.
• W2065448466 cites W2161012666 @default.
• W2065448466 cites W2170714458 @default.
• W2065448466 cites W2172547375 @default.
• W2065448466 cites W4247262390 @default.
• W2065448466 doi "https://doi.org/10.1016/0306-4522(87)90279-x" @default.
• W2065448466 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2446202" @default.
• W2065448466 hasPublicationYear "1987" @default.
• W2065448466 type Work @default.
• W2065448466 sameAs 2065448466 @default.
• W2065448466 citedByCount "251" @default.
• W2065448466 countsByYear W20654484662012 @default.
• W2065448466 countsByYear W20654484662013 @default.
• W2065448466 countsByYear W20654484662014 @default.
• W2065448466 countsByYear W20654484662015 @default.
• W2065448466 countsByYear W20654484662016 @default.
• W2065448466 countsByYear W20654484662017 @default.
• W2065448466 countsByYear W20654484662018 @default.
• W2065448466 countsByYear W20654484662019 @default.
• W2065448466 countsByYear W20654484662020 @default.
• W2065448466 countsByYear W20654484662021 @default.
• W2065448466 countsByYear W20654484662022 @default.
• W2065448466 countsByYear W20654484662023 @default.
• W2065448466 crossrefType "journal-article" @default.
• W2065448466 hasAuthorship W2065448466A5042615490 @default.
• W2065448466 hasAuthorship W2065448466A5053447405 @default.
• W2065448466 hasAuthorship W2065448466A5053509756 @default.
• W2065448466 hasConcept C10335311 @default.
• W2065448466 hasConcept C1122143 @default.
• W2065448466 hasConcept C126322002 @default.
• W2065448466 hasConcept C134018914 @default.
• W2065448466 hasConcept C159545944 @default.
• W2065448466 hasConcept C170493617 @default.
• W2065448466 hasConcept C185592680 @default.
• W2065448466 hasConcept C24998067 @default.
• W2065448466 hasConcept C2776885963 @default.
• W2065448466 hasConcept C2778501154 @default.
• W2065448466 hasConcept C2778938600 @default.
• W2065448466 hasConcept C2779090179 @default.
• W2065448466 hasConcept C2781041448 @default.
• W2065448466 hasConcept C34400551 @default.
• W2065448466 hasConcept C55493867 @default.
• W2065448466 hasConcept C63180777 @default.
• W2065448466 hasConcept C71924100 @default.

• next