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- W2065451580 abstract "The pulmonary vein is surrounded by an external sleeve of cardiomyocytes that are widely recognised to play an important role in atrial fibrillation. While intracellular Ca(2+) is thought to influence the electrical activity of cardiomyocytes, there have been relatively few studies examining Ca(2+) signalling in these cells. Therefore, using fluo-4 and fluorescence imaging microscopy, we have investigated Ca(2+) signalling in an intact section of the rat pulmonary vein. Under resting conditions cardiomyocytes displayed spontaneous Ca(2+) transients, which were variable in amplitude and had a frequency of 1.6±0.03Hz. The Ca(2+) transients were asynchronous amongst neighbouring cardiomyocytes and tended to propagate throughout the cell as a wave. Removing extracellular Ca(2+) produced a slight reduction in the amplitude and frequency of the spontaneous Ca(2+) transients; however, ryanodine (20μM) had a much greater effect on the amplitude and reduced the frequency by 94±2%. Blocking IP(3) receptors with 2-aminoethoxydiphenyl borate (20μM) also reduced the amplitude and frequency (by 73±11%) of these events, indicating the importance of Ca(2+) release from the SR. Electrical field stimulation of the pulmonary vein produced Ca(2+) transients in cardiomyocytes that were significantly reduced by either voltage-gated Ca(2+) channel blockers or ryanodine." @default.
- W2065451580 created "2016-06-24" @default.
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- W2065451580 date "2010-08-01" @default.
- W2065451580 modified "2023-09-27" @default.
- W2065451580 title "Spontaneous and electrically evoked Ca2+ transients in cardiomyocytes of the rat pulmonary vein" @default.
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- W2065451580 doi "https://doi.org/10.1016/j.ceca.2010.08.002" @default.
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