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• W2065453800 endingPage "10649" @default.
• W2065453800 startingPage "10640" @default.
• W2065453800 abstract "This paper examines covalent reactivity of AchE with respect to cationic and uncharged methylphosphonates and substrates in the absence and presence of cationic ligands selective for the active center and the peripheral anionic site. The organophosphorus inhibitors are enantiomeric alkyl methylphosphonothioates (1-5) containing cycloheptyl and isopropyl phosphono ester groups and S-methyl, S-n-pentyl, and S-[beta-(trimethylammonio)ethyl] leaving groups; these agents differ in their configuration about phosphorus and their steric, hydrophobic, and electrostatic characteristics. The synthetic substrates examined are acetylthiocholine, p-nitrophenyl acetate, and 7-acetoxy-4-methylcoumarin (7AMC). Antagonism of the methylphosphonothioate reaction by cationic ligands is strongly dependent on the nature of both the cation and the methylphosphonate but independent of the configuration about phosphorus. While all cations cause linear mixed inhibition of acetylthiocholine hydrolysis, there are observed a variety of inhibition patterns of 7AMC and p-nitrophenyl acetate hydrolysis that are distinctly nonlinear, as well as patterns in which the reciprocal plots intersect in the upper right quadrant. Strong antagonism of cationic (methylphosphonyl)thiocholines correlates very well with linear inhibition of acetylthiocholine. Ligands that cause only negligible antagonism of the uncharged methylphosphonates display nonlinear inhibition of uncharged substrates. These relationships, since they are most pronounced for peripheral site ligands and are strongly dependent on the charge carried by the reactant, suggest that the peripheral anionic site alters enzyme reactivity through an electrostatic interaction with the net negative active center. Such behavior indicates a potential role for the peripheral anionic site in conserving AchE catalytic efficiency within a narrow range of values." @default.
• W2065453800 created "2016-06-24" @default.
• W2065453800 creator A5068054693 @default.
• W2065453800 creator A5080877380 @default.
• W2065453800 date "1990-11-01" @default.
• W2065453800 modified "2023-10-01" @default.
• W2065453800 title "Ligand exclusion on acetylcholinesterase" @default.
• W2065453800 cites W125799310 @default.
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• W2065453800 doi "https://doi.org/10.1021/bi00499a010" @default.
• W2065453800 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2271673" @default.
• W2065453800 hasPublicationYear "1990" @default.
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