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• W2065458595 abstract "The polymeric Ig receptor (pIgR) ensures efficient secretion of polymeric IgA (pIgA) at mucosal surfaces. On basal to apical transport across epithelial cells, the pIgR extracellular domain is cleaved, releasing secretory component (SC) in association with pIgA. This finds its raison d'être in the recent observation that SC is directly involved in the protective function of secretory IgA. In addition, free SC exhibits scavenger properties with respect to enteric pathogens. However, although pIgR dedicates its life to mucosal protection, it also seems to permit pathogen entrance through the epithelial barrier. The multiple mechanisms that they are involved in make pIgR and SC instrumental to mucosal immunity." @default.
• W2065458595 created "2016-06-24" @default.
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• W2065458595 date "2003-02-01" @default.
• W2065458595 modified "2023-10-18" @default.
• W2065458595 title "Novel functions of the polymeric Ig receptor: well beyond transport of immunoglobulins" @default.
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• W2065458595 doi "https://doi.org/10.1016/s1471-4906(02)00031-5" @default.
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