Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065483677> ?p ?o ?g. }
- W2065483677 endingPage "317" @default.
- W2065483677 startingPage "307" @default.
- W2065483677 abstract "P450 aromatase (CYP19) is the terminal enzyme in the steroidogenic pathway and catalyzes the conversion of androgens to estrogens. Fundulus heteroclitus like other teleosts, express two CYP19 genes, CYP19A1 and CYP19A2. The expression of CYP19s in Fundulus was measured by in situ hybridization throughout development. In 90 dpf (day post-fertilization) fish and adult fish, CYP19A1 was expressed in the ooplasm of early stage I oocytes (primary growth stage). Expression of CYP19A1 was localized in the follicle cell layer of late stage I (previtellogenic stage) and stage II (vitellogenic stage) follicles, but by stage III (early maturational follicles) CYP19A1 expression was localized in the vitelline envelope. Overall, CYP19A1 oocyte membrane expression gradually declined from highest expression at late stage I to nondetectable levels by stage IV. Highest expression of CYP19A2 was detected in the brain including the hypothalamus from 4, 6, 8, 10, 14 dpf embryos, 90 dpf fry fish and adult fish brain. In females compared to males, there was higher CYP19A2 expression in olfactory bulb. In addition to the brain, there was strong CYP19A2 signal in adrenal/kidney cells in 6-14 dpf embryos. This work establishes the localization and constitutive expression of CYP19s in Fundulus which can then be compared with potential disruption of CYP19A1 and CYP19A2 expression and physiological consequences caused by environmental contaminants." @default.
- W2065483677 created "2016-06-24" @default.
- W2065483677 creator A5043741186 @default.
- W2065483677 creator A5046454314 @default.
- W2065483677 date "2008-01-01" @default.
- W2065483677 modified "2023-10-16" @default.
- W2065483677 title "Local expression of CYP19A1 and CYP19A2 in developing and adult killifish (Fundulus heteroclitus)" @default.
- W2065483677 cites W1266342965 @default.
- W2065483677 cites W1597141462 @default.
- W2065483677 cites W1911135642 @default.
- W2065483677 cites W1963655571 @default.
- W2065483677 cites W1967288203 @default.
- W2065483677 cites W1971547524 @default.
- W2065483677 cites W1973001565 @default.
- W2065483677 cites W1978641783 @default.
- W2065483677 cites W1979449534 @default.
- W2065483677 cites W1990274911 @default.
- W2065483677 cites W1997095741 @default.
- W2065483677 cites W2000765298 @default.
- W2065483677 cites W2003453112 @default.
- W2065483677 cites W2007071598 @default.
- W2065483677 cites W2007499818 @default.
- W2065483677 cites W2009545059 @default.
- W2065483677 cites W2010399333 @default.
- W2065483677 cites W2016581179 @default.
- W2065483677 cites W2018649334 @default.
- W2065483677 cites W2020660715 @default.
- W2065483677 cites W2025188669 @default.
- W2065483677 cites W2027007754 @default.
- W2065483677 cites W2027438208 @default.
- W2065483677 cites W2029343946 @default.
- W2065483677 cites W2033085951 @default.
- W2065483677 cites W2033878590 @default.
- W2065483677 cites W2037001136 @default.
- W2065483677 cites W2037659246 @default.
- W2065483677 cites W2040295623 @default.
- W2065483677 cites W2040530362 @default.
- W2065483677 cites W2042901848 @default.
- W2065483677 cites W2048203178 @default.
- W2065483677 cites W2053767918 @default.
- W2065483677 cites W2056931310 @default.
- W2065483677 cites W2058375232 @default.
- W2065483677 cites W2077563858 @default.
- W2065483677 cites W2078326225 @default.
- W2065483677 cites W2086523920 @default.
- W2065483677 cites W2093233505 @default.
- W2065483677 cites W2095915766 @default.
- W2065483677 cites W2096888246 @default.
- W2065483677 cites W2097155470 @default.
- W2065483677 cites W2097360502 @default.
- W2065483677 cites W2111668426 @default.
- W2065483677 cites W2112656147 @default.
- W2065483677 cites W2119521512 @default.
- W2065483677 cites W2126168000 @default.
- W2065483677 cites W2127803065 @default.
- W2065483677 cites W2131379063 @default.
- W2065483677 cites W2138700889 @default.
- W2065483677 cites W2139350439 @default.
- W2065483677 cites W2150545576 @default.
- W2065483677 cites W2157704923 @default.
- W2065483677 cites W2161357971 @default.
- W2065483677 cites W2162581076 @default.
- W2065483677 cites W2164668113 @default.
- W2065483677 cites W2164939673 @default.
- W2065483677 cites W2168612083 @default.
- W2065483677 cites W2186115142 @default.
- W2065483677 cites W2277696240 @default.
- W2065483677 cites W2487915609 @default.
- W2065483677 cites W352966374 @default.
- W2065483677 cites W4241962388 @default.
- W2065483677 cites W4253601422 @default.
- W2065483677 doi "https://doi.org/10.1016/j.ygcen.2007.05.018" @default.
- W2065483677 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2254941" @default.
- W2065483677 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17582409" @default.
- W2065483677 hasPublicationYear "2008" @default.
- W2065483677 type Work @default.
- W2065483677 sameAs 2065483677 @default.
- W2065483677 citedByCount "34" @default.
- W2065483677 countsByYear W20654836772012 @default.
- W2065483677 countsByYear W20654836772013 @default.
- W2065483677 countsByYear W20654836772014 @default.
- W2065483677 countsByYear W20654836772016 @default.
- W2065483677 countsByYear W20654836772017 @default.
- W2065483677 countsByYear W20654836772018 @default.
- W2065483677 countsByYear W20654836772019 @default.
- W2065483677 countsByYear W20654836772020 @default.
- W2065483677 countsByYear W20654836772021 @default.
- W2065483677 countsByYear W20654836772023 @default.
- W2065483677 crossrefType "journal-article" @default.
- W2065483677 hasAuthorship W2065483677A5043741186 @default.
- W2065483677 hasAuthorship W2065483677A5046454314 @default.
- W2065483677 hasBestOaLocation W20654836772 @default.
- W2065483677 hasConcept C104317684 @default.
- W2065483677 hasConcept C121608353 @default.
- W2065483677 hasConcept C126322002 @default.
- W2065483677 hasConcept C134018914 @default.
- W2065483677 hasConcept C150194340 @default.
- W2065483677 hasConcept C16685009 @default.