Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065484927> ?p ?o ?g. }
- W2065484927 endingPage "754" @default.
- W2065484927 startingPage "738" @default.
- W2065484927 abstract "The current 5-year survival rate of pancreatic cancer is about 3% and the median survival less than 6 months because the chemotherapy and radiation therapy presently available provide only marginal benefit. Clearly, pancreatic cancer requires new therapeutic concepts. Recently, the kinase inhibitors imatinib and gefitinib, developed to treat chronic myelogenous leukaemia and breast cancer, respectively, gave very good results. Kinases are deregulated in many diseases, including cancer. Given that phosphorylation controls cell survival signalling, strategies targeting kinases should obviously improve cancer treatment. The purpose of this review is to summarize the present knowledge on kinases potentially usable as therapeutic targets in the treatment of pancreatic cancer. All clinical trials using available kinase inhibitors in monotherapy or in combination with chemotherapeutic drugs failed to improve survival of patients with pancreatic cancer. To detect kinases relevant to this disease, we undertook a systematic screening of the human kinome to define a 'survival kinase' catalogue for pancreatic cells. We selected 56 kinases that are potential therapeutic targets in pancreatic cancer. Preclinical studies using combined inhibition of PAK7, MAP3K7 and CK2 survival kinases in vitro and in vivo showed a cumulative effect on apoptosis induction. We also observed that these three kinases are rather specific of pancreatic cancer cells. In conclusion, if kinase inhibitors presently available are unfortunately not efficient for treating pancreatic cancer, recent data suggest that inhibitors of other kinases, involved more specifically in pancreatic cancer development, might, in the future, become interesting therapeutic targets." @default.
- W2065484927 created "2016-06-24" @default.
- W2065484927 creator A5029085609 @default.
- W2065484927 creator A5066948009 @default.
- W2065484927 creator A5075989679 @default.
- W2065484927 date "2009-01-01" @default.
- W2065484927 modified "2023-09-27" @default.
- W2065484927 title "A Review of Kinases Implicated in Pancreatic Cancer" @default.
- W2065484927 cites W1494491432 @default.
- W2065484927 cites W1531792564 @default.
- W2065484927 cites W1544851750 @default.
- W2065484927 cites W1574172480 @default.
- W2065484927 cites W1576671418 @default.
- W2065484927 cites W1586153330 @default.
- W2065484927 cites W1593569420 @default.
- W2065484927 cites W1594706458 @default.
- W2065484927 cites W1726025741 @default.
- W2065484927 cites W1902628090 @default.
- W2065484927 cites W1914212739 @default.
- W2065484927 cites W1963794965 @default.
- W2065484927 cites W1964010757 @default.
- W2065484927 cites W1964321121 @default.
- W2065484927 cites W1966260349 @default.
- W2065484927 cites W1966291495 @default.
- W2065484927 cites W1966453709 @default.
- W2065484927 cites W1969328947 @default.
- W2065484927 cites W1969785844 @default.
- W2065484927 cites W1970079579 @default.
- W2065484927 cites W1971294233 @default.
- W2065484927 cites W1971695868 @default.
- W2065484927 cites W1971915141 @default.
- W2065484927 cites W1972161092 @default.
- W2065484927 cites W1972343960 @default.
- W2065484927 cites W1974517994 @default.
- W2065484927 cites W1977455794 @default.
- W2065484927 cites W1978975184 @default.
- W2065484927 cites W1982711630 @default.
- W2065484927 cites W1983055247 @default.
- W2065484927 cites W1988106051 @default.
- W2065484927 cites W1988824838 @default.
- W2065484927 cites W1989631932 @default.
- W2065484927 cites W1990317973 @default.
- W2065484927 cites W1991683855 @default.
- W2065484927 cites W1992677777 @default.
- W2065484927 cites W1996647025 @default.
- W2065484927 cites W1997224330 @default.
- W2065484927 cites W1997865069 @default.
- W2065484927 cites W2000894976 @default.
- W2065484927 cites W2002714857 @default.
- W2065484927 cites W2002999999 @default.
- W2065484927 cites W2003738818 @default.
- W2065484927 cites W2005792688 @default.
- W2065484927 cites W2007030561 @default.
- W2065484927 cites W2008803651 @default.
- W2065484927 cites W2011957331 @default.
- W2065484927 cites W2012460154 @default.
- W2065484927 cites W2014383618 @default.
- W2065484927 cites W2015338496 @default.
- W2065484927 cites W2015942742 @default.
- W2065484927 cites W2018348203 @default.
- W2065484927 cites W2019195072 @default.
- W2065484927 cites W2020537787 @default.
- W2065484927 cites W2024165683 @default.
- W2065484927 cites W2024893931 @default.
- W2065484927 cites W2025313715 @default.
- W2065484927 cites W2028562167 @default.
- W2065484927 cites W2030753600 @default.
- W2065484927 cites W2034406895 @default.
- W2065484927 cites W2034548257 @default.
- W2065484927 cites W2037746145 @default.
- W2065484927 cites W2042702886 @default.
- W2065484927 cites W2045500858 @default.
- W2065484927 cites W2048058951 @default.
- W2065484927 cites W2048245178 @default.
- W2065484927 cites W2050041795 @default.
- W2065484927 cites W2050422354 @default.
- W2065484927 cites W2052550764 @default.
- W2065484927 cites W2053624316 @default.
- W2065484927 cites W2054870962 @default.
- W2065484927 cites W2056561005 @default.
- W2065484927 cites W2056574134 @default.
- W2065484927 cites W2057937439 @default.
- W2065484927 cites W2059028043 @default.
- W2065484927 cites W2063001537 @default.
- W2065484927 cites W2065289702 @default.
- W2065484927 cites W2067754613 @default.
- W2065484927 cites W2070732456 @default.
- W2065484927 cites W2072734055 @default.
- W2065484927 cites W2073212944 @default.
- W2065484927 cites W2075091190 @default.
- W2065484927 cites W2075626786 @default.
- W2065484927 cites W2078605907 @default.
- W2065484927 cites W2079286299 @default.
- W2065484927 cites W2082387343 @default.
- W2065484927 cites W2083308747 @default.
- W2065484927 cites W2086262311 @default.
- W2065484927 cites W2088172171 @default.
- W2065484927 cites W2088601895 @default.